CAS 147059-72-1

Trovafloxacina

Descrição:

Trovafloxacina é um antibiótico fluoroquinolona sintético que exibe uma atividade antibacteriana de amplo espectro. É utilizado principalmente para tratar várias infecções bacterianas, particularmente aquelas causadas por organismos Gram-positivos e Gram-negativos. O composto atua inibindo a girase do DNA bacteriano e a topoisomerase IV, enzimas críticas para a replicação e transcrição do DNA, impedindo assim a divisão e o crescimento celular bacteriano. Trovafloxacina é caracterizado por sua potência relativamente alta contra certos patógenos, incluindo aqueles resistentes a outros antibióticos. É tipicamente administrado por via oral ou intravenosa e possui um perfil farmacocinético favorável, permitindo a dosagem uma vez ao dia em muitos casos. No entanto, seu uso tem sido limitado devido a preocupações sobre hepatotoxicidade e o potencial para efeitos colaterais graves, levando à sua retirada do mercado em algumas regiões. Além disso, como outras fluoroquinolonas, pode estar associado a riscos de ruptura de tendões e efeitos no sistema nervoso central. No geral, embora Trovafloxacina demonstre propriedades antibacterianas eficazes, seu perfil de segurança requer consideração cuidadosa no uso clínico.

Fórmula: C₂₀H₁₅F₃N₄O₃

InChI: InChI=1/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+

Chave InChI: InChIKey=WVPSKSLAZQPAKQ-CDMJZVDBNA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3=C(F)C=C(F)C=C3)=NC(=C(F)C2)N4C[C@]5([C@@](C4)([C@@H]5N)[H])[H]

Sinónimos:

• (1α,5α,6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2,4-difluomphenyl)-6-fluom-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
• 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
• 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv.
• 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• Cp-99219
• Trovan：CP-99219-27
• Turvel
• Trovafloxacin
• 7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-

CAS: 147059-72-1

Fórmula: C₂₀H₁₅F₃N₄O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 416.3533

Ref: IN-DA001EKY

Trovafloxacin

CAS: 147059-72-1

Fórmula: C₂₀H₁₅F₃N₄O₃

Peso molecular: 416.35

Ref: 7W-GP2666

Trovafloxacin

CAS: 147059-72-1

Trovafloxacin, a broad-spectrum quinolone antibiotic, exhibits potent activity against Gram-positive bacteria.

Fórmula: C₂₀H₁₅F₃N₄O₃

Pureza: 99.21% - 99.27%

Cor e Forma: Solid

Peso molecular: 416.35

Ref: TM-T13231

Trovafloxacin

Produto Controlado

CAS: 147059-72-1

Applications Trovafloxacin is a fluroquinolone antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice.
References Garg, C., et al.: J. Neuroinflammation, 15, 42 (2018); Angus, J. A., et al.: Eur. J. Pharmacol., 791, 179 (2016)

Fórmula: C₂₀H₁₅F₃N₄O₃

Cor e Forma: Neat

Peso molecular: 402.37

Ref: TR-T892760

(1R,5R,6R)-7-(6-Amino-3-Azabicyclo[3.1.0]Hex-3- Yl)-1-(2,4-difluorophenyl)-6-Fluoro-1,4-dihydro-4-Oxo-1,8-naphthyridine-3-carbox

CAS: 147059-72-1

The mechanism of action of ciprofloxacin is to bind to the bacterial ribosome, thereby inhibiting protein synthesis. Ciprofloxacin is a broad-spectrum antibiotic that has been shown to be effective against both gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Ciprofloxacin is also active against Mycobacterium tuberculosis and Mycobacterium avium complex. It binds to the 30S ribosomal subunit, preventing attachment of aminoacyl tRNA. The addition of tetracycline can increase the activity of ciprofloxacin by inhibiting the efflux pump in the bacterial cell membrane. Ciprofloxacin has been found to have synergistic effects when used in combination with trovafloxacin or other antibiotics that act on different targets.

Fórmula: C₂₀H₁₅F₃N₄O₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 416.35 g/mol

Ref: 3D-FA103840