CAS 147081-49-0

(R)-tert-butil 3-aminopirrolidina-1-carboxilato

Descrição:

(R)-tert-butil 3-aminopirrolidina-1-carboxilato é um composto quiral caracterizado por sua estrutura de anel de pirrolidina, que é um heterociclo de cinco membros contendo nitrogênio. A presença do grupo tert-butilo aumenta sua lipofilicidade, tornando-o mais solúvel em solventes orgânicos. Este composto apresenta um grupo amino e um grupo funcional carboxilato, que contribuem para seu potencial como bloco de construção na síntese orgânica e aplicações farmacêuticas. A quiralidade da molécula, indicada pela configuração (R), é significativa na determinação de sua atividade biológica e interações com outras moléculas quirais. O número CAS 147081-49-0 identifica de forma única esta substância em bancos de dados químicos, facilitando seu estudo e aplicação em vários campos, incluindo química medicinal e desenvolvimento de medicamentos. Suas características estruturais sugerem usos potenciais na síntese de moléculas mais complexas, particularmente no desenvolvimento de fármacos direcionados a vias biológicas específicas. No geral, (R)-tert-butil 3-aminopirrolidina-1-carboxilato é um composto versátil com importantes implicações na pesquisa e aplicação química.

Fórmula: C₉H₁₈N₂O₂

InChI: InChI=1/C9H18N2O2.ClH/c1-9(2,3)13-8(12)11-5-4-7(10)6-11;/h7H,4-6,10H2,1-3H3;1H/t7-;/m1./s1

Chave InChI: InChIKey=CMIBWIAICVBURI-SSDOTTSWSA-N

SMILES: C(OC(C)(C)C)(=O)N1CC[C@@H](N)C1

Sinónimos:

• (+)-3-Aminopyrrolidine-1-carboxylic acid (R)-tert-butyl ester
• (3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
• (3R)-3-Aminopyrrolidine-1-carboxylic acid tert-butyl ester
• (R)-(+)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
• (R)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
• (R)-1-Boc-3-aminopyrrolidine
• (R)-1-N-Boc-3-Aminopyrrolidine
• (R)-3-Amino-1-Boc-pyrrolidine
• (R)-3-Amino-1-tert-butoxycarbonylpyrrolidine
• (R)-3-Amino-N-(tert-butoxycarbonyl)pyrrolidine
• (R)-3-Aminopyrrolidine-1-carboxylic acid tert-butyl ester
• (R)-N-tert-Butoxycarbonyl-3-aminopyrrolidine
• (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate
• 1,1-Dimethylethyl (3R)-3-amino-1-pyrrolidinecarboxylate
• 1,1-dimethylethyl (3R)-3-aminopyrrolidine-1-carboxylate
• 1-Boc-(R)-3-aminopyrrolidine
• 1-Boc-3-(R)-aminopyrrolidine
• 1-N-Boc-3-(R)-aminopyrrolidine
• 1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3R)-
• 1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (R)-
• 1-t-butoxycarbonyl-3-R-aminopyrrolidine
• N-Boc-(3R)-aminopyrrolidine
• R-1-N-Boc-3-Amino Pyrrolidine
• R-N-boc-3-Amino Pyrrolidine
• tert-Butyl (R)-3-amino-1-pyrrolidinecarboxylate
• tert-Butyl (R)-3-aminopyrrolidine-1-carboxylate
• tert-butyl (3R)-3-aminopyrrolidine-1-carboxylate
• (R)-N-Boc-3-aminopyrrolidine
• (R)-3-AMINO-1-N-(T-BUTOXYCARBONYL)PYRROLIDINE
• (R)-3-AMINO-1-N-BOC-PYRROLIDINE, CITRIC ACID SALT
• (R)-3-AMINO-1-N-(TERT-BUTOXYCARBONYL)PYRROLIDINE
• (R)-3-AMINO-N-BOC-PYRROLIDINE
• (R)-(+)-1-TBOC-3-AMINOPYRROLIDINE
• (3R)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
• 3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, (R)
• (R)-3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine

CAS: 147081-49-0

Fórmula: C₉H₁₈N₂O₂

Pureza: >98.0%(GC)(T)

Cor e Forma: Colorless to Light orange to Yellow clear liquid

Peso molecular: 186.26

Ref: 3B-B2920

(R)-(+)-1-Boc-3-aminopyrrolidine, 97%

CAS: 147081-49-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₉H₁₈N₂O₂

Pureza: 97%

Cor e Forma: Clear colorless to pale yellow, Liquid

Peso molecular: 186.26

Ref: 02-H28188

(3R)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

CAS: 147081-49-0

Fórmula: C₉H₁₈N₂O₂

Pureza: 95%

Cor e Forma: Liquid

Peso molecular: 186.2514

Ref: IN-DA0032DY

(3R)-3-Aminopyrrolidine, N1-BOC protected

CAS: 147081-49-0

(3R)-3-Aminopyrrolidine, N1-BOC protected

Fórmula: C₉H₁₈N₂O₂

Pureza: 95%

Cor e Forma: colourless liquid

Peso molecular: 186.25g/mol

Ref: 54-OR4635

(R)-3-Amino-1-N-Boc-pyrrolidine

CAS: 147081-49-0

Fórmula: C₉H₁₈N₂O₂

Pureza: 98.0%

Cor e Forma: Liquid, Oil

Peso molecular: 186.255

Ref: 10-F011315

(R)-1-Boc-3-Aminopyrrolidine

CAS: 147081-49-0

(R)-1-Boc-3-Aminopyrrolidine is a small molecule that inhibits 3-kinase. It has been shown to bind to the ATP binding site of PI3Kδ and inhibit its activity. This results in the inhibition of phosphoinositide production, which leads to decreased cell proliferation and survival. (R)-1-Boc-3-Aminopyrrolidine has also been shown to have selectivity for isoform α over β, γ, and δ. The drug binds specifically to the ATP binding site on PI3Kδ, but does not disrupt other interactions such as hydrogen bonding or pi stacking interactions with residues in the vicinity of the ATP binding site. The IC50 values for (R)-1-Boc-3-Aminopyrrolidine were determined using siRNA knockdown experiments against human isoform α PI3Kδ.

Fórmula: C₉H₁₈N₂O₂

Pureza: Min. 95%

Peso molecular: 186.25 g/mol

Ref: 3D-FB41617