CAS 147127-20-6
:Tenofovir
Descrição:
Tenofovir é um medicamento antirretroviral utilizado principalmente no tratamento e prevenção do HIV/AIDS e da hepatite B crônica. Pertence à classe dos inibidores da transcriptase reversa de nucleotídeos (NRTIs) e funciona inibindo a enzima transcriptase reversa, que é crucial para a replicação viral. A estrutura química de Tenofovir inclui um grupo fosfonato, que contribui ao seu mecanismo de ação. Geralmente é administrado na forma de seu sal de fumarato de disoproxilo, melhorando sua biodisponibilidade. Tenofovir é conhecido por seu perfil de segurança relativamente favorável, embora possa estar associado à toxicidade renal e à perda de densidade mineral óssea em alguns pacientes. A substância é solúvel em água, o que facilita sua formulação em formas de dosagem oral. Sua farmacocinética envolve rápida absorção e conversão à sua forma ativa, Tenofovir difosfato, dentro das células. Como um componente chave das terapias combinadas, Tenofovir desempenha um papel significativo no manejo da infecção por HIV e também é utilizado na profilaxia pré-exposição (PrEP) para reduzir o risco de transmissão do HIV.
Fórmula:C9H14N5O4P
InChI:InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
Chave InChI:InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N
SMILES:C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2
Sinónimos:- P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
- Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
- (R)-9-(2-Phosphonomethoxypropyl)adenine
- Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
- Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-
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16 produtos.
Tenofovir
CAS:Fórmula:C9H14N5O4PPureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalinePeso molecular:287.22Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
CAS:Fórmula:C9H14N5O4PPureza:95%Cor e Forma:SolidPeso molecular:287.2123Tenofovir
CAS:Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.Fórmula:C9H14N5O4PPureza:98.69% - 99.92%Cor e Forma:White To Tan Solid Solid PowderPeso molecular:287.21Tenofovir
CAS:Fórmula:C9H14N5O4PPureza:≥ 98.0% (anhydrous)Cor e Forma:White to off-white powderPeso molecular:287.21Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C9H14N5O4PCor e Forma:White To Off-WhitePeso molecular:287.21Tenofovir
CAS:<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.</p>Fórmula:C9H14N5O4PPureza:Min. 95%Cor e Forma:White Clear LiquidPeso molecular:287.21 g/molTenofovir - Bio-X ™
CAS:<p>Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. <br>Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C9H14N5O4PPureza:Min. 98.5 Area-%Cor e Forma:White To Off-White SolidPeso molecular:287.21 g/mol(R)-9-(2-Phosphonomethoxypropyl)adenine
CAS:Fórmula:C9H14N5O4PPureza:95%Cor e Forma:SolidPeso molecular:287.216Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)
CAS:Produto Controlado<p>Impurity Tenofovir Impurity<br>Stability Light Sensitive<br>Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.<br>References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C18H29N6O9PCor e Forma:NeatPeso molecular:504.431
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