CAS 147127-20-6

Tenofovir

Descrição:

Tenofovir é um medicamento antirretroviral utilizado principalmente no tratamento e prevenção do HIV/AIDS e da hepatite B crônica. Pertence à classe dos inibidores da transcriptase reversa de nucleotídeos (NRTIs) e funciona inibindo a enzima transcriptase reversa, que é crucial para a replicação viral. A estrutura química de Tenofovir inclui um grupo fosfonato, que contribui ao seu mecanismo de ação. Geralmente é administrado na forma de seu sal de fumarato de disoproxilo, melhorando sua biodisponibilidade. Tenofovir é conhecido por seu perfil de segurança relativamente favorável, embora possa estar associado à toxicidade renal e à perda de densidade mineral óssea em alguns pacientes. A substância é solúvel em água, o que facilita sua formulação em formas de dosagem oral. Sua farmacocinética envolve rápida absorção e conversão à sua forma ativa, Tenofovir difosfato, dentro das células. Como um componente chave das terapias combinadas, Tenofovir desempenha um papel significativo no manejo da infecção por HIV e também é utilizado na profilaxia pré-exposição (PrEP) para reduzir o risco de transmissão do HIV.

Fórmula: C₉H₁₄N₅O₄P

InChI: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

Chave InChI: InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES: C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2

Sinónimos:

• P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
• Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• (R)-9-(2-Phosphonomethoxypropyl)adenine
• Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystaline

Peso molecular: 287.22

Ref: 3B-T3006

Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 287.2123

Ref: IN-DA001EMI

Tenofovir

CAS: 147127-20-6

Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.

Fórmula: C₉H₁₄N₅O₄P

Pureza: 98.69% - 99.92%

Cor e Forma: White To Tan Solid Solid Powder

Peso molecular: 287.21

Ref: TM-T1649

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: ≥ 98.0% (anhydrous)

Cor e Forma: White to off-white powder

Peso molecular: 287.21

Ref: 7W-GP5400

Tenofovir

CAS: 147127-20-6

Tenofovir

Pureza: ≥98%

Peso molecular: 287.21g/mol

Ref: 54-BUP16961

Tenofovir

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Cor e Forma: White To Off-White Solid

Peso molecular: 287.22

Ref: 4Z-T-023

Tenofovir

CAS: 147127-20-6

Tenofovir

Pureza: 98%

Peso molecular: 287.21g/mol

Ref: 54-OR1030259

Tenofovir

Produto Controlado

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Cor e Forma: Neat

Peso molecular: 287.21

Ref: 86-MM1329.19-0025

Tenofovir

CAS: 147127-20-6

Cor e Forma: Neat

Ref: 86-MM1329.19

Tenofovir (1.0 mg/mL in Water)

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Cor e Forma: Single Solution

Peso molecular: 287.21

Ref: TR-KIT7765

Tenofovir

CAS: 147127-20-6

Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Fórmula: C₉H₁₄N₅O₄P

Cor e Forma: White To Off-White

Peso molecular: 287.21

Ref: TR-T018500

Tenofovir - Bio-X ™

CAS: 147127-20-6

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. 
Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₉H₁₄N₅O₄P

Pureza: Min. 98.5 Area-%

Cor e Forma: White To Off-White Solid

Peso molecular: 287.21 g/mol

Ref: 3D-BT164455

Tenofovir

CAS: 147127-20-6

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.

Fórmula: C₉H₁₄N₅O₄P

Pureza: Min. 95%

Cor e Forma: White Clear Liquid

Peso molecular: 287.21 g/mol

Ref: 3D-FT10480

(R)-9-(2-Phosphonomethoxypropyl)adenine

CAS: 147127-20-6

Fórmula: C₉H₁₄N₅O₄P

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 287.216

Ref: 10-F077792

Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)

Produto Controlado

CAS: 147127-20-6

Impurity Tenofovir Impurity
Stability Light Sensitive
Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.
References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Fórmula: C₁₈H₂₉N₆O₉P

Cor e Forma: Neat

Peso molecular: 504.431

Ref: TR-M540865

Tenofovir-d5

Produto Controlado

CAS: 147127-20-6

Fórmula: C₉D₅H₉N₅O₄P

Cor e Forma: Neat

Peso molecular: 292.243

Ref: TR-T018503