CAS 1476-52-4

(±)-Desetilcloroquina

Descrição:

(±)-Desetilcloroquina é um composto químico que é um derivado da cloroquina, conhecido principalmente por seu uso como agente antimalárico. Esta substância é caracterizada por sua modificação estrutural, especificamente a remoção do grupo etila da molécula de cloroquina. Apresenta propriedades que podem influenciar sua atividade farmacológica, incluindo potenciais efeitos antivirais. O composto possui um centro quiral, levando à existência de enantiômeros, que podem exibir diferentes atividades biológicas. (±)-Desetilcloroquina é solúvel em solventes orgânicos e tem solubilidade limitada em água, o que pode afetar sua biodisponibilidade e eficácia terapêutica. Acredita-se que seu mecanismo de ação envolva a interferência no processo de polimerização de heme em parasitas da malária, bem como uma possível modulação das respostas imunológicas. A pesquisa sobre sua farmacocinética, perfil de segurança e aplicações terapêuticas continua, particularmente no contexto de doenças infecciosas emergentes. Assim como muitos compostos farmacêuticos, entender suas características é crucial para desenvolver protocolos de tratamento eficazes.

Fórmula: C₁₆H₂₂ClN₃

InChI: InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

Chave InChI: InChIKey=MCYUUUTUAAGOOT-UHFFFAOYSA-N

SMILES: N(C(CCCNCC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinónimos:

• (±)-Desethylchloroquine
• 1,4-Pentanediamine N4-(7-chloro-4-quinolinyl)-N1-ethyl-
• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹-ethyl-
• 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline
• 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline
• Chloroquine, deethyl-
• Deethylchloroquine
• Monodeethylchloroquine
• Monodesethylchloroquine
• N-Deethylchloroquine
• N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
• N⁴-(7-Chloro-4-quinolinyl)-N¹-ethyl-1,4-pentanediamine
• Nsc 13254
• N~4~-(7-chloroquinolin-4-yl)-N~1~-ethylpentane-1,4-diamine
• Quinoline, 7-chloro-4-[[4-(ethylamino)-1-methylbutyl]amino]-

Chloroquine Related Compound D (7-Chloro-4-{[4-(ethylamino)-1-methylbutyl] amino} quinoline)

CAS: 1476-52-4

Compounds (excluding drugs and pesticides) containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused, nesoi

Fórmula: C₁₆H₂₂ClN₃

Cor e Forma: Tan Powder

Peso molecular: 291.15023

Ref: 45-1118350

1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 291.8190

Ref: IN-DA001F0N

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine

Pureza: ≥98%

Peso molecular: 291.82g/mol

Ref: 54-BUP17493

Hydroxychloroquine Sulfate EP Impurity D HBr (Chloroquine USP Related Compound D HBr, Desethyl Chloroquine HBr)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃·HBr

Cor e Forma: White To Off-White Solid

Peso molecular: 291.82 80.91

Ref: 4Z-H-0640

Hydroxychloroquine Sulfate EP Impurity D (Chloroquine USP Related Compound D, Desethyl Chloroquine)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃

Cor e Forma: White To Off-White Solid

Peso molecular: 291.82

Ref: 4Z-H-0638

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.

Fórmula: C₁₆H₂₂ClN₃

Pureza: 99.56%

Cor e Forma: Solid

Peso molecular: 291.82

Ref: TM-T11001

Hydroxychloroquine Sulfate EP Impurity D DiHBr (Chloroquine USP Related Compound D DiHBr, Desethyl Chloroquine DiHBr)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃·2HBr

Cor e Forma: White To Off-White Solid

Peso molecular: 291.82 2*80.91

Ref: 4Z-H-0618

Hydroxychloroquine Sulfate EP Impurity D TriHCl (Chloroquine USP Related Compound D TriHCl, Desethyl Chloroquine TriHCl)

CAS: 1476-52-4

Fórmula: C₁₆H₂₂ClN₃·3HCl

Peso molecular: 291.83 3*36.46

Ref: 4Z-H-0665

Desethyl Chloroquine

Produto Controlado

CAS: 1476-52-4

Applications Desethyl Chloroquine is the major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product.
References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

Fórmula: C₁₆H₂₂ClN₃

Cor e Forma: Light Yellow To Dark Yellow

Peso molecular: 291.82

Ref: TR-D288735

Desethyl chloroquine

CAS: 1476-52-4

Desethyl chloroquine is a drug that is used to treat malaria and other infectious diseases. It is an antimalarial drug that has been shown to be effective in the treatment of malaria and related diseases such as toxoplasmosis, amebiasis, trypanosomiasis, and leishmaniasis. Methods for the preparation of desethyl chloroquine are described in the analytical section. To measure the concentration of desethyl chloroquine in blood, it is recommended to collect a sample of blood by venipuncture or fingerstick. The concentration-time curve in blood can be analyzed using a fluorescence detector and LC-MS/MS method. When analyzing pharmacokinetic properties, it is important to take into account the matrix effect due to human serum proteins. Desethyl chloroquine has potent inducers that affect its pharmacokinetics and metabolism, including CYP3A4 enzymes and glutathione reductase.

Fórmula: C₁₆H₂₂ClN₃

Pureza: Min. 95%

Cor e Forma: Slightly Yellow Powder

Peso molecular: 291.82 g/mol

Ref: 3D-FD21174