CAS 1476-53-5

Novobiocina sódica

Descrição:

Novobiocina sódica, com o número CAS 1476-53-5, é um composto antibiótico que pertence à classe dos derivados de cumarina. É derivado principalmente da bactéria *Streptomyces niveus* e apresenta propriedades antibacterianas, particularmente contra bactérias Gram-positivas. A novobiocina atua inibindo a girase do DNA bacteriano, uma enzima crítica para a replicação e transcrição do DNA, interrompendo assim o crescimento bacteriano. A forma de sal sódico melhora sua solubilidade em soluções aquosas, tornando-a adequada para várias aplicações farmacêuticas. Além de sua atividade antibacteriana, a novobiocina tem sido estudada por seu potencial uso em terapia contra o câncer devido à sua capacidade de inibir certos processos celulares. O composto é tipicamente administrado em um ambiente clínico e está sujeito a diretrizes específicas de dosagem devido aos seus efeitos farmacológicos. Perfis de segurança e eficácia são considerações essenciais em seu uso, assim como em qualquer antibiótico, para prevenir o desenvolvimento de resistência e garantir resultados terapêuticos ideais.

Fórmula: C₃₁H₃₆N₂O₁₁·Na

InChI: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/t23-,25+,26-,29-;/m1./s1

Chave InChI: InChIKey=BZFOBLOAMAJKQV-RNROJPEYSA-N

SMILES: CC1=C2C(C(O)=C(NC(=O)C3=CC(CC=C(C)C)=C(O)C=C3)C(=O)O2)=CC=C1O[C@H]4[C@H](O)[C@H](OC(N)=O)[C@@H](OC)C(C)(C)O4.[Na]

Sinónimos:

• (3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• 5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• Albamycin
• Albamycin (capsule)
• Albamycin sodium
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-, sodium salt (1:1)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
• Cathomycin sodium
• Cathomycin sodium lyovac
• Monosodium novobiocin
• N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
• NSC 2382
• Novobiocin Sodium
• Novobiocin Sodium Crystalline
• Novobiocin Sodium Usp
• Novobiocin monosodium
• Novobiocin, monosodium salt
• Novobiocin, sodium deriv.
• Sodium albamycin
• Sodium novobiocin
• Vulcamycin
• sodium 7-{[(2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-4-olate (non-preferred name)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt, 1476-53-5, is an antibiotic compound produced by Streptomyces nieveus which inhibits topoisomerase II. Learn more at Thermo Fisher Scientific.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Cor e Forma: White to pale cream to yellow, Powder

Peso molecular: 634.61

Ref: 02-J60928

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: 99% - 99.28%

Cor e Forma: Solid

Peso molecular: 634.61

Ref: TM-T0974

Novobiocin Sodium Salt

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 634.6062

Ref: IN-DA00AOT3

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium

Pureza: ≥98%

Peso molecular: 634.61g/mol

Ref: 54-BUP11826

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt

Fórmula: C₃₁H₃₅N₂O₁₁·Na

Pureza: By hplc: 96.2% by area (Typical Value in Batch COA)

Cor e Forma: off white powder

Peso molecular: 634.60617g/mol

Ref: 54-BIN0394

Novobiocin sodium salt

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: ≥ 95.0% (dried basis)

Cor e Forma: White to off-white powder

Peso molecular: 634.61

Ref: 7W-GA5711

Novobiocin sodium salt, USP grade

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: ≥ 90.0%

Cor e Forma: White to off-white powder

Peso molecular: 634.61

Ref: 7W-GP5629

Novobiocin sodium

Produto Controlado

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂O₁₁·Na

Cor e Forma: Neat

Peso molecular: 634.61

Ref: 04-C15654200

Novobiocin Sodium Salt

Produto Controlado

CAS: 1476-53-5

Stability Hygroscopic
Applications Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
References Cozarelli, N.R.: Science, 207, 953 (1980); Sumiyoshi, Y. et al.: J. Gen. Virol., 64, 2329 (1983); Lockshon, G. et al.: Nucleic Acids Res., 11, 2999 (1983);

Fórmula: C₃₁H₃₅N₂O₁₁·Na

Cor e Forma: Neat

Peso molecular: 634.61

Ref: TR-N888500

Novobiocin sodium salt, Antibiotic for Culture Media Use Only

CAS: 1476-53-5

Novobiocin sodium salt inhibits bacterial growth by binding to the 50S subunit of the bacterial ribosome, blocking the peptidyl transferase activity required for protein synthesis. The drug binds to DNA sequences containing glucuronic acid, which are essential for peptide bond formation. Novobiocin sodium can be found in pharmaceuticals due to its antimicrobial activity and membrane stability, which makes it suitable for pressuring ionization techniques. It also exhibits less resistance than other antibiotics like triclosan or nalidixic acid because it does not typically bind to the membranes of cells.

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: Min. 90.0 Area-%

Peso molecular: 634.61 g/mol

Ref: 3D-N-9100

Novobiocin sodium

CAS: 1476-53-5

Inhibitor of prokaryotic DNA gyrase, eukaryotic DNA topoisomerase and HSP90

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: Min. 94%

Cor e Forma: Powder

Peso molecular: 634.61 g/mol

Ref: 3D-EN15775

Novobiocin Sodium Salt (NVB), 95%

CAS: 1476-53-5

Fórmula: C₃₁H₃₅N₂NaO₁₁

Pureza: min. 95%

Cor e Forma: White to pale yellow, Powder, Clear

Peso molecular: 634.61

Ref: SR-27434