CAS 147794-23-8

ômega-conotoxina mviic

Descrição:

A omega-conotoxina MVIIA é um peptídeo derivado do veneno do caracol Conus, especificamente do Conus magus. É um bloqueador potente e seletivo dos canais de cálcio dependentes de voltagem do tipo N (VGCC), que desempenham um papel crucial na liberação de neurotransmissores e na sinalização da dor. Essa característica torna a omega-conotoxina MVIIA de grande interesse na farmacologia, particularmente por suas potenciais aplicações no manejo da dor e na pesquisa neurológica. O peptídeo consiste em uma sequência específica de aminoácidos que contribui para sua estrutura e função únicas. Apresenta alta afinidade pelos canais de cálcio do tipo N, inibindo a entrada de cálcio e, assim, reduzindo a liberação de neurotransmissores, o que pode aliviar a dor. A omega-conotoxina MVIIA também é estudada por seus potenciais efeitos terapêuticos em vários distúrbios neurológicos. Devido à sua origem em organismos marinhos, representa um exemplo fascinante de como produtos naturais podem levar ao desenvolvimento de novos agentes farmacológicos. Sua estabilidade e especificidade a tornam uma ferramenta valiosa tanto na pesquisa quanto em potenciais aplicações clínicas.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Sinónimos:

• w-Conotoxin MVIIC, Conus magus
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys26)
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2 (Disulfide Bridge: 1-16, 8-20, And 15-26)
• Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• Ckgkgapcrktmydccsgscgrrgkc-Nh2 (Disulfide Bridge: 1-16,8-20 And 15-26)
• Omega-Cgtx Mviic
• Omega-Conotoxin Mviic, Conus Magus

ω-Conotoxin MVIIC

CAS: 147794-23-8

Like ω-conotoxin GVIA, this Conus magus peptide inhibits presynaptic Ca²⁺ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca²⁺ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: > 98%

Cor e Forma: White Powder

Peso molecular: 2749.29

Ref: 01-4030522

ω-Conotoxin MVIIC

CAS: 147794-23-8

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: 98%

Cor e Forma: White Lyophilised Solid

Peso molecular: 2749

Ref: TM-TP2064

ω-Conotoxin MVIIC

CAS: 147794-23-8

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Peso molecular: 2749.25

Ref: 7W-GK3612

Omega-Conotoxin MVIIC

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide that binds to the nicotinic acetylcholine receptor and activates it, leading to inhibition of neurotransmitter release. It is used as a research tool for studying the pharmacology of ion channels and their ligands. Omega-Conotoxin MVIIC is purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons. CONOTOXINS are small peptides that bind to the nicotinic acetylcholine receptor and activate it, leading to inhibition of neurotransmitter release. They are used as research tools for studying the pharmacology of ion channels and their ligands. CONOTOXINS are purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons.END> END>

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: Min. 95%

Peso molecular: 2,749.3 g/mol

Ref: 3D-PCN-4283-S

ω-Conotoxin MVIIC

CAS: 147794-23-8

Omega-conotoxins are a group of peptides found in the venom of predatory marine snails. Omega-conotoxin MVIIC is a potent inhibitor of nicotinic acetylcholine receptors. It blocks the activation and desensitization of nicotinic acetylcholine receptor channels and has been used as a research tool to study the function of these proteins. Omega-conotoxin MVIIC binds to its target by interacting with specific sites on the alpha subunit of nicotinic acetylcholine receptor channels, which leads to inhibition of voltage-gated calcium channels. The high purity and low endotoxin levels make this product suitable for life science research applications.

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: Min. 95%

Peso molecular: 2,749.3 g/mol

Ref: 3D-PCN-4283-V

Omega-Conotoxin MVIIC

Produto Controlado

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide toxin that blocks the voltage-dependent calcium channels. It has been shown to have neuroprotective properties and to inhibit glutamate induced neurotoxicity in vitro and in vivo. Omega-Conotoxin MVIIC inhibits neurotransmitter release by blocking the calcium channels and thereby reduces oxidative stress, which prevents neuronal cell death. This toxin also blocks the activity of voltage-dependent sodium channels, but its effects are not as potent as those on calcium channels. Omega-Conotoxin MVIIC has been found to be effective against cerebellar granule neurons, as well as other neurons in the brainstem, cerebellum, hippocampus, and cerebral cortex. The molecular weight of this toxin is approximately 10 kDa and it contains subunits (a total of eight).

Fórmula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 2,749.26 g/mol

Ref: 3D-FC110353