CAS 148408-66-6

trihidrato de docetaxel

Descrição:

trihidrato de docetaxel é um agente quimioterápico semissintético derivado do teixo, especificamente do composto paclitaxel. É utilizado principalmente no tratamento de vários tipos de câncer, incluindo câncer de mama, pulmão e próstata. A substância é caracterizada por sua capacidade de inibir a divisão celular estabilizando os microtúbulos, impedindo assim a degradação normal do fuso mitótico durante a divisão celular. trihidrato de docetaxel é tipicamente administrado por via intravenosa e é conhecido por sua eficácia em promover a apoptose em células cancerosas. Em termos de propriedades físicas, aparece como um pó cristalino branco a off-white, e sua forma de trihidrato indica a presença de três moléculas de água associadas a cada molécula de docetaxel. O composto é solúvel em solventes orgânicos como etanol e dimetilsulfóxido, mas tem solubilidade limitada em água. Sua farmacocinética envolve um extenso metabolismo no fígado, principalmente através das enzimas do citocromo P450, e é excretado principalmente pela bile. Assim como muitos agentes quimioterápicos, trihidrato de docetaxel pode ter efeitos colaterais significativos, incluindo neutropenia, fadiga e distúrbios gastrointestinais.

Fórmula: C₄₃H₅₃NO₁₄·3H₂O

InChI: InChI=1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1

Chave InChI: InChIKey=XCDIRYDKECHIPE-QHEQPUDQSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H].O

Sinónimos:

• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (betaS)-, hydrate (1:3)
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, hydrate (1:3), (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, trihydrate, (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Docetaxel・Trihydrate
• Taxespira
• Docetaxel.Trihydrate
• Docetaxel trihydrate
• Docetaxel(Trihydrate)

DOCETAXEL TRIHYDRATE CRS

CAS: 148408-66-6

DOCETAXEL TRIHYDRATE CRS

Fórmula: C₄₃H₅₃NO₁₄

Cor e Forma: Crystalline Powder. White. Powder.

Peso molecular: 807.8792

Ref: 41-Y0001133

DOCETAXEL FOR SYSTEM SUITABILITY CRS

CAS: 148408-66-6

DOCETAXEL FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001155

Docetaxel ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate)

CAS: 148408-66-6

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₄₃H₅₃NO₁₄·3H₂O

Cor e Forma: White Powder

Peso molecular: 807.34661

Ref: 45-1224551

Docetaxel trihydrate

CAS: 148408-66-6

Docetaxel trihydrate

Pureza: ≥98%

Peso molecular: 861.95g/mol

Ref: 54-BUP16556

Docetaxel Impurity 78

CAS: 148408-66-6

Fórmula: C₄₃H₅₁NO₁₄

Peso molecular: 805.87

Ref: 4Z-D-1919

Docetaxel Trihydrate

Produto Controlado

CAS: 148408-66-6

Fórmula: C₄₃H₅₃NO₁₄H₂O

Cor e Forma: Neat

Peso molecular: 861.93

Ref: 86-MM3396.00

Docetaxel RS

CAS: 148408-66-6

Cor e Forma: White Solid Crystalline Powder

Ref: 2K-1090300021

Docetaxel Crotonaldehyde Analog

Produto Controlado

CAS: 148408-66-6

Fórmula: C₄₃H₅₁NO₁₄

Cor e Forma: Neat

Peso molecular: 805.86

Ref: TR-D525620

Docetaxel-d5

Produto Controlado

CAS: 148408-66-6

Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.
References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Fórmula: C₄₃D₅H₄₈NO₁₄

Cor e Forma: Neat

Peso molecular: 812.91

Ref: TR-D494423

Docetaxel trihydrate

CAS: 148408-66-6

A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.

Fórmula: C₄₃H₅₃NO₁₄•(H₂O)₃

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 861.93 g/mol

Ref: 3D-FD29606

Docetaxel trihydrate - Bio-X ™

CAS: 148408-66-6

Docetaxel is a cytotoxic semi-synthetic taxane and is an anthracycline antibiotic. The compound is an anti-microtubule agent and has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.
Docetaxel trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₄₃H₅₃NO₁₄•(H₂O)₃

Pureza: Min. 90 Area-%

Peso molecular: 861.93 g/mol

Ref: 3D-BD164375

Docetaxel trihydrate

CAS: 148408-66-6

Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis.

Fórmula: C₄₃H₅₉NO₁₇

Pureza: 98.68% - >99.99%

Cor e Forma: White Crystalline Powder

Peso molecular: 861.95

Ref: TM-T0186