CAS 148408-66-6
:trihidrato de docetaxel
Descrição:
trihidrato de docetaxel é um agente quimioterápico semissintético derivado do teixo, especificamente do composto paclitaxel. É utilizado principalmente no tratamento de vários tipos de câncer, incluindo câncer de mama, pulmão e próstata. A substância é caracterizada por sua capacidade de inibir a divisão celular estabilizando os microtúbulos, impedindo assim a degradação normal do fuso mitótico durante a divisão celular. trihidrato de docetaxel é tipicamente administrado por via intravenosa e é conhecido por sua eficácia em promover a apoptose em células cancerosas. Em termos de propriedades físicas, aparece como um pó cristalino branco a off-white, e sua forma de trihidrato indica a presença de três moléculas de água associadas a cada molécula de docetaxel. O composto é solúvel em solventes orgânicos como etanol e dimetilsulfóxido, mas tem solubilidade limitada em água. Sua farmacocinética envolve um extenso metabolismo no fígado, principalmente através das enzimas do citocromo P450, e é excretado principalmente pela bile. Assim como muitos agentes quimioterápicos, trihidrato de docetaxel pode ter efeitos colaterais significativos, incluindo neutropenia, fadiga e distúrbios gastrointestinais.
Fórmula:C43H53NO14·3H2O
InChI:InChI=1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1
Chave InChI:InChIKey=XCDIRYDKECHIPE-QHEQPUDQSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H].O
Sinónimos:- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (betaS)-, hydrate (1:3)
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, hydrate (1:3), (αR,βS)-
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, trihydrate, (αR,βS)-
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- Docetaxel・Trihydrate
- Taxespira
- Docetaxel.Trihydrate
- Docetaxel trihydrate
- Docetaxel(Trihydrate)
- Ver mais sinónimos
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Pureza (%)
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100
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0
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50
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90
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95
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100
12 produtos.
DOCETAXEL TRIHYDRATE CRS
CAS:DOCETAXEL TRIHYDRATE CRSFórmula:C43H53NO14Cor e Forma:Crystalline Powder. White. Powder.Peso molecular:807.8792Docetaxel ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate)
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFórmula:C43H53NO14·3H2OCor e Forma:White PowderPeso molecular:807.34661Docetaxel Trihydrate
CAS:Produto ControladoFórmula:C43H53NO14H2OCor e Forma:NeatPeso molecular:861.93Docetaxel Crotonaldehyde Analog
CAS:Produto ControladoFórmula:C43H51NO14Cor e Forma:NeatPeso molecular:805.86Docetaxel-d5
CAS:Produto Controlado<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>Fórmula:C43D5H48NO14Cor e Forma:NeatPeso molecular:812.91Docetaxel trihydrate
CAS:<p>A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.</p>Fórmula:C43H53NO14•(H2O)3Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:861.93 g/molDocetaxel trihydrate - Bio-X ™
CAS:<p>Docetaxel is a cytotoxic semi-synthetic taxane and is an anthracycline antibiotic. The compound is an anti-microtubule agent and has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.<br>Docetaxel trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C43H53NO14•(H2O)3Pureza:Min. 90 Area-%Peso molecular:861.93 g/molDocetaxel trihydrate
CAS:Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis.Fórmula:C43H59NO17Pureza:98.68% - >99.99%Cor e Forma:White Crystalline PowderPeso molecular:861.95
