CAS 14897-39-3

Rifamicina sódica

Descrição:

Rifamicina sódica é um composto antibiótico usado principalmente no tratamento de infecções bacterianas, particularmente aquelas causadas por Mycobacterium tuberculosis, a bactéria responsável pela tuberculose. Pertence à classe dos antibióticos rifamicinas, que se caracterizam pela sua capacidade de inibir a síntese de RNA bacteriano ligando-se à enzima RNA polimerase dependente de DNA. Este mecanismo de ação torna as rifamicinas eficazes contra um amplo espectro de bactérias gram-positivas e algumas gram-negativas. Rifamicina sódica é tipicamente administrado em sua forma de sal sódico para aumentar a solubilidade e a biodisponibilidade. É frequentemente utilizado em combinação com outros agentes antituberculosos para prevenir o desenvolvimento de resistência a medicamentos. O composto é conhecido por seus potenciais efeitos colaterais, que podem incluir toxicidade hepática e interações com outros medicamentos devido ao seu efeito sobre as enzimas hepáticas. Além disso, é importante monitorar os pacientes em busca de sinais de reações de hipersensibilidade. No geral, Rifamicina sódica é um componente crítico no manejo da tuberculose e outras infecções bacterianas, contribuindo significativamente para os esforços de saúde pública contra essas doenças.

Fórmula: C₃₇H₄₆NNaO₁₂

InChI: InChI=1/C37H47NO12.Na.H/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);;/b11-10-,14-13-,17-12u;;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;;/m0../s1/rC37H47NO12.HNa/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);1H/b11-10-,14-13-,17-12u;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1

Chave InChI: InChIKey=URCDBMLCEGDNOK-NLYBMVFSSA-N

SMILES: O=C1C=2C=3C4=C(O)C(=CC3O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O.[Na]

Sinónimos:

• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, sodium salt
• Cb 01-11
• Monosodium rifamycin SV
• NSC 146718
• Rifamycin SV Monosodium
• Rifamycin SV sodium salt
• Rifamycin Sodium
• Rifamycin sodium salt
• Rifamycin, monosodium salt
• Rifamycin, sodium salt (1:1)
• Tuborin
• RIFAMPICIN SV SODIUM
• Rifamycin SV hexahydrate sodium salt
• 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, monosodium salt
• (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione sodium salt
• Rifamycin SV s
• Rifamycinsodiumsal
• Rifamycin Sodium USP/EP/BP
• Rifamycin Na USP/EP/BP
• RIFAMYCIN,MONOSODIUMSALT
• 5,6,9,17,19,21-Hexahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-
• Rifamycin sodium CRS
• Rifamycin SV sodium, >=900 IU/mg
• RIFAMYCIN SV SODIUM SALT HEXAHYDRATE
• RifaMycin SV MonosodiuM salt
• RIFAMYCIN SV-SODIUM

Rifamycin SV sodium, 98+%

CAS: 14897-39-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₃₇H₄₆NNaO₁₂

Pureza: 98+%

Cor e Forma: Red, Crystalline powder

Peso molecular: 719.45

Ref: 02-J63095

RIFAMYCIN SODIUM CRS

CAS: 14897-39-3

RIFAMYCIN SODIUM CRS

Fórmula: C₃₇H₄₆NNaO₁₂

Peso molecular: 719.7504

Ref: 41-R1000000

FIRST INTERNATIONAL STANDARD FOR RIFAMYCIN SV

CAS: 14897-39-3

FIRST INTERNATIONAL STANDARD FOR RIFAMYCIN SV

Fórmula: C₃₇H₄₆NNaO₁₂

Peso molecular: 719.7504

Ref: 41-ISA_66_231

2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, sodium salt

CAS: 14897-39-3

Fórmula: C₃₇H₄₇NNaO₁₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 720.7584

Ref: IN-DA001LAU

Rifamycin sodium

CAS: 14897-39-3

Rifamycin sodium

Pureza: ≥95%

Peso molecular: 719.75g/mol

Ref: 54-BUP11801

Rifaximin EP Impurity C Sodium Salt (Rifamycin SV Sodium Salt)

CAS: 14897-39-3

Fórmula: C₃₇H₄₆NO₁₂·Na

Cor e Forma: Red Solid

Peso molecular: 696.77 22.99

Ref: 4Z-R-3513

Rifamycin sodium salt

CAS: 14897-39-3

Fórmula: C₃₇H₄₆NNaO₁₂

Cor e Forma: Orange, red or brown-red powder

Peso molecular: 719.45

Ref: 7W-GA6855

Rifamycin Sodium

CAS: 14897-39-3

Rifamycin Sodium

Pureza: 97%

Peso molecular: 720.76g/mol

Ref: 54-OR1028410

Rifamycin Sodium (Rifamycin SV Sodium)

CAS: 14897-39-3

Cor e Forma: Neat

Ref: 86-MM3747.00

Rifamycin sodium

CAS: 14897-39-3

Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase.

Fórmula: C₃₇H₄₆NNaO₁₂

Pureza: 97.72%

Cor e Forma: Coa

Peso molecular: 719.75

Ref: TM-T5003

Rifamycin SV Sodium

CAS: 14897-39-3

Impurity Rifaximin EP Impurity C
Applications Rifamycin SV Sodium (Rifaximin EP Impurity C) is a semi-synthetic antibiotic derived from Rifamycin S. (1) Antibacterial (2). Potency >900 units (dry basis).
References 1. Sensi, P. et al.: Experientia. 1960 Sep 15;16:412.2. Mascherpa, P., et al.: Biochem. Pharmacol. 1966 Feb;15(2):200-4.

Fórmula: C₃₇H₄₆NO₁₂·Na

Cor e Forma: Red

Peso molecular: 719.75

Ref: TR-R508200

Rifaximin EP Impurity C

CAS: 14897-39-3

Fórmula: C₃₇H₄₆NO₁₂Na

Peso molecular: 696.8 : 23.0

Ref: ST-EA-CP-R42008

Rifamycin SV sodium

CAS: 14897-39-3

Rifamycin SV sodium is a hydroxide solution of the antibiotic rifamycin. Rifamycin SV sodium inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Fórmula: C₃₇H₄₆NNaO₁₂

Pureza: Min 900U/Mg

Cor e Forma: Powder

Peso molecular: 719.75 g/mol

Ref: 3D-FR27730

Rifamycin SV sodium - Bio-X ™

CAS: 14897-39-3

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₃₇H₄₆NNaO₁₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 719.75 g/mol

Ref: 3D-BR300118

Rifamycin sodium

CAS: 14897-39-3

Peso molecular: 719.76

Ref: 10-F986312