CAS 149-29-1

Patulina

Descrição:

Patulina é uma micotoxina produzida por várias espécies de fungos, particularmente Penicillium e Aspergillus. É um sólido cristalino incolor a amarelo pálido com um odor característico. Patulina é conhecido por suas propriedades antimicrobianas, que podem inibir o crescimento de certas bactérias e fungos; no entanto, é reconhecido principalmente por seus potenciais riscos à saúde, particularmente em segurança alimentar. É comumente encontrado em frutas em decomposição, especialmente maçãs, e pode contaminar sucos de frutas e outros produtos alimentares. Patulina é classificado como uma substância perigosa devido aos seus efeitos tóxicos, que podem incluir distúrbios gastrointestinais e potencial carcinogenicidade. Agências reguladoras estabeleceram limites para os níveis de Patulina em produtos alimentares para mitigar os riscos à saúde. Sua estrutura química apresenta um anel de lactona, contribuindo para sua reatividade e atividade biológica. Devido à sua presença nos suprimentos alimentares, a pesquisa em andamento se concentra em métodos para detecção, prevenção e degradação de Patulina em produtos agrícolas.

Fórmula: C₇H₆O₄

InChI: InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2

Chave InChI: InChIKey=ZRWPUFFVAOMMNM-UHFFFAOYSA-N

SMILES: OC1C=2C(OC(=O)C2)=CCO1

Sinónimos:

• 4,6-Dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-on
• 4,6-dihidro-4-hidroxi-2H-furo[3,2-c]piran-2-ona
• 4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyran-2-one
• 4,6-dihydro-4-hydroxy-2H-furo[3,2-c]pyranne-2-one
• 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
• <span class="text-smallcaps">DL</span>-Patulin
• Acetic acid, (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone
• Clairformin
• Clavacin
• Clavatin
• Claviformin
• DL-Patulin
• Expansin
• Expansin (antibiotic)
• Expansine
• Gigantin
• Leucopin
• Mycoin
• Mycoin C
• Mycoin C3
• Mycoin C₃
• Nsc 32951
• Nsc 8120
• Patulin
• Patuline
• Penicidin
• Terinin
• CCRIS 4940
• Tercinin
• Claviform
• Mycoine C3
• HSDB 3522
• (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid, 3,4-lactone
• 2H-Pyran-delta(sup 3(6H),alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone
• (4R)-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
• 5-18-03-00005 (Beilstein Handbook Reference)
• 4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-
• Penatin
• 4H-Furo(3,2-c)pyran-2(6H)-one, 4-hydroxy-
• BRN 0149675
• 2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid-3,4-lactone
• (4S)-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
• 4H-Furo(3,3-c)pyran-2(6H)-one, 4-hydroxy-
• (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone

4H-FURO[3,2-C]PYRAN-2(6H)-ONE, 4-HYDROXY-

CAS: 149-29-1

Fórmula: C₇H₆O₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 154.1201

Ref: IN-DA001LCB

Patulin Standard Solution

CAS: 149-29-1

Patulin Standard Solution

Fórmula: C₇H₆O₄

Cor e Forma: Colourless Liquid

Peso molecular: 154.12g/mol

Ref: 54-BIMS108

Patulin from Penicillium expansum

CAS: 149-29-1

Patulin from Penicillium expansum

Fórmula: C₇H₆O₄

Pureza: By hplc: 100% (Typical Value in Batch COA)

Cor e Forma: white crystals

Peso molecular: 154.12g/mol

Ref: 54-BIP1003

Patulin

CAS: 149-29-1

Fórmula: C₇H₆O₄

Pureza: ≥ 98.0%

Cor e Forma: White to pale yellow crystalline powder

Peso molecular: 154.12

Ref: 7W-GA7014

Patulin 100 µg/mL in Acetonitrile

Produto Controlado

CAS: 149-29-1

Fórmula: C₇H₆O₄

Cor e Forma: Single Solution

Peso molecular: 154.12

Ref: 04-A15896000AL-100

Patulin 100 µg/mL in Acetonitrile

Produto Controlado

CAS: 149-29-1

Fórmula: C₇H₆O₄

Cor e Forma: Single Solution

Peso molecular: 154.12

Ref: 04-V15896000AL-100

Patulin

Produto Controlado

CAS: 149-29-1

Fórmula: C₇H₆O₄

Cor e Forma: Neat

Peso molecular: 154.12

Ref: 04-C15896000

PATULIN

CAS: 149-29-1

Patulin (Claviform) is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.

Fórmula: C₇H₆O₄

Pureza: 99.91% - 99.98%

Cor e Forma: Compact Prisms Or Thick Plates From Ether Or Chloroform White Crystalline

Peso molecular: 154.12

Ref: TM-T3936

Patulin

CAS: 149-29-1

Stability Hygroscopic
Applications Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. Patulin-induced genotoxicity and modulation of glutathione in Hep G2 cells. Patulin is an antibiotic. Patulin-induced nephropathy and gastrointestinal tract malfunction have been demonstrated in several animal models. The oral LD50 value of patulin ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry. The World Health Organization considers patulin cytotoxic and established a safety level of patulin in apple juice at 50 μM. At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells. In 1944, this compound was tested in a clinical trial for potential antibiotic
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Scott, P., et al.: J. Agric. Food Chem., 20, 450 (1972), Aden, D., et al.: Nature, 282, 615 (1979), Surralles, J., et al.: Mutat. Res., 341, 169 (1995), Alves, I., et al.: Mutagenesis, 15, 229 (2000), Liu, B., et al.: Toxicol. Appl. Pharmacol., 191, 255 (2003), Puel, O., Galtier, P., and Oswald, I.P. Biosynthesis and toxicological effects of patulin. Toxins 2(4) 613-631 (2010). Liu, B., Wu, T., Yu, F., et al. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicol Sci 95(2) 340-347 (2007). Chalmers, I., and Clarke, M. Commentary: The 1994 patulin trial: The first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int J Epidemiol 32 253-260 (2004).

Fórmula: C₇H₆O₄

Cor e Forma: Off-White To Yellow

Peso molecular: 154.12

Ref: TR-P206500

Patulin

CAS: 149-29-1

Patulin is a mycotoxin, which is a toxic secondary metabolite produced by certain species of fungi, particularly those within the genera Penicillium, Aspergillus, and Byssochlamys. It is predominantly sourced from moldy fruits, especially apples and apple-derived products, where these fungi thrive and synthesize the compound. The mode of action of patulin involves disrupting cellular processes by forming covalent adducts with proteins and nucleic acids, ultimately leading to cellular damage and oxidative stress.

Fórmula: C₇H₆O₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 154.12 g/mol

Ref: 3D-FP31796

Patulin

CAS: 149-29-1

Fórmula: C₇H₆O₄

Peso molecular: 154.12

Ref: ST-EA-CP-A174011