CAS 1492-18-8

Folínico de cálcio

Descrição:

Folínico de cálcio, também conhecido como leucovorina ou fator citrovorum, é um sal de cálcio do ácido folínico, que é um derivado do ácido fólico. É comumente utilizado em aplicações médicas, particularmente como um medicamento para reduzir os efeitos tóxicos de certos agentes de quimioterapia, como o metotrexato, fornecendo uma fonte de folato reduzido. Este composto é caracterizado por sua aparência cristalina de branco a amarelo pálido e é solúvel em água, tornando-o adequado para administração intravenosa ou oral. Folínico de cálcio desempenha um papel crucial no metabolismo celular, particularmente na síntese de ácidos nucleicos e aminoácidos, que são essenciais para a divisão e crescimento celular. Seu mecanismo de ação envolve a conversão em formas ativas de folato, que podem contornar o bloqueio metabólico causado por medicamentos antifolato. Além disso, é utilizado no tratamento da anemia megaloblástica e como terapia de suporte em vários tratamentos de câncer. Os perfis de segurança e eficácia estão bem estabelecidos, mas deve ser usado sob supervisão médica devido a possíveis interações com outros medicamentos.

Fórmula: C₂₀H₂₃N₇O₇·Ca

InChI: InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/t12?,13-;/m0./s1

Chave InChI: InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O.[Ca]

Sinónimos:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Calcium 5-formyltetrahydrofolate
• Calcium <span class="text-smallcaps">L</span>-folinate
• Calcium Folinate
• Calcium Folinate(Folinic Acid)(Rg)
• Calcium L-Folinate
• Calcium leucovorin
• Calcium2-[4-[(2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl] Aminopentanedioate
• Calciumfolinat
• Folidan
• Folinate De Calcium
• Folinate-SF calcium
• Folinato Calcico
• Folinic acid Calcium salt
• Folinic acid calcium salt USP28
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), L-
• L-Calcium Folinate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Lederfoline
• Leucovorin Calcium
• Leucovorin calcium salt
• LeucovorinCalcium
• Leucovorine calcium
• Nsc 3590
• Rescuvolin
• Wellcovorin
• calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light orange to Yellow to Green powder to crystaline

Peso molecular: 511.51

Ref: 3B-C2235

Folinic acid calcium salt hydrate, 98%

CAS: 1492-18-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: 98%

Peso molecular: 511.51

Ref: 02-H60181

CALCIUM FOLINATE CRS

CAS: 1492-18-8

CALCIUM FOLINATE CRS

Ref: 41-C0250000

CALCIUM FOLINATE (LEUCOVORIN CALCIUM) RS

CAS: 1492-18-8

CALCIUM FOLINATE (LEUCOVORIN CALCIUM) RS

Fórmula: C₂₀H₂₁CaN₇O₇

Peso molecular: 511.5014

Ref: 41-ICRS0236

Calcium folinate

CAS: 1492-18-8

Calcium folinate

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: 76.0%

Cor e Forma: Light Yellow

Peso molecular: 511.11284

Ref: 47-923

Leucovorin Calcium

CAS: 1492-18-8

Other vitamins and their derivatives, nesoi

Fórmula: C₂₀H₂₁CaN₇O₇

Cor e Forma: Yellow Powder

Peso molecular: 511.11284

Ref: 45-1358004

L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)

CAS: 1492-18-8

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 511.5014

Ref: IN-DA001LG9

Folinic acid calcium

CAS: 1492-18-8

Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: 98.72% - >99.99%

Cor e Forma: Yellow Crystalline Powder

Peso molecular: 511.51

Ref: TM-T0148

Folinic acid calcium salt

CAS: 1492-18-8

Folinic acid calcium salt

Pureza: 98%

Cor e Forma: Powder

Peso molecular: 511.50143g/mol

Ref: 54-BIC0607

Folinic acid calcium salt hydrate

CAS: 1492-18-8

Fórmula: C₂₀H₂₁CaN₇O₇·xH₂O

Pureza: 97.5 - 102.5 % (anhydrous basis)

Cor e Forma: Light-yellow to yellow-orange powder

Peso molecular: 511.51 (anhydrous)

Ref: 7W-GP6553

Folinic acid calcium

CAS: 1492-18-8

Folinic acid calcium

Pureza: ≥98%

Peso molecular: 511.51g/mol

Ref: 54-BUP17377

Folinic acid calcium salt hydrate, USP grade

CAS: 1492-18-8

Fórmula: C₂₀H₂₁CaN₇O₇·xH₂O

Pureza: (HPLC) 95.0 - 105.0 % (anhydrous substance)

Cor e Forma: Yellow-white to yellow powder

Peso molecular: 511.50 (anhydrous)

Ref: 7W-GV5663

Folinic Acid Calcium Salt ((6RS)-Calcium Levofolinate EP Impurity H Calcium Salt, Leucovorin Calcium Salt)

CAS: 1492-18-8

Fórmula: C₂₀H₂₁N₇O₇·Ca

Peso molecular: 471.43 40.08

Ref: 4Z-F-068044

Folinate calcium 100 µg/mL in Water

CAS: 1492-18-8

Fórmula: C₂₀H₂₁N₇O₇·Ca

Cor e Forma: Colourless

Peso molecular: 511.50

Ref: 04-A13888500WA-100

Folinate calcium

Produto Controlado

CAS: 1492-18-8

Fórmula: C₂₀H₂₁N₇O₇·Ca

Cor e Forma: Light Yellow

Peso molecular: 511.50

Ref: 04-C13888500

Calcium Folinate

CAS: 1492-18-8

Fórmula: C₂₀H₂₁N₇O₇·Ca

Cor e Forma: Neat

Peso molecular: 511.50

Ref: 86-MM0324.00

Calcium Folinate RS

CAS: 1492-18-8

Cor e Forma: White To Light Yellow Solid Crystalline Powder

Ref: 2K-1154000021

Folinic Acid Calcium Salt

CAS: 1492-18-8

Stability Hygroscopic
Applications Folinic Acid Calcium Salt is a derivative of Folic Acid (F680300), a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).
References Frye, R. et al.: Mol. Psych., 18, 369 (2013); Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Fórmula: C₂₀H₂₁N₇O₇·Ca

Cor e Forma: Light Yellow

Peso molecular: 511.5

Ref: TR-F680320

Calcium folinate

CAS: 1492-18-8

Dihydrofolate reductase activator; decreases methotrexate toxicity

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 511.50 g/mol

Ref: 3D-FC61510

Leucovorin calcium salt - Bio-X ™

CAS: 1492-18-8

Leucovorin is a folate analog drug that is used to treat the toxic effects of methotrexate and other antagonists of folate. It works by counteracting the toxic effects of methrotrexate by inhibiting the enzyme dihydrofolate reductase. It is used to increase the levels of folic acid and by strengthening the link between the active metabolite (5-FdUMP) and the enzyme thymidylate synthetase, leucovorin increases the action of fluorouracil. Additionally, in order to increase survival in patients undergoing palliative treatment for colorectal cancer, it is used in conjunction with 5-fluorouracil.

Fórmula: C₂₀H₂₃N₇O₇·Ca

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 513.52 g/mol

Ref: 3D-BC164621