CAS 14930-96-2

Citochalasin B

Descrição:

Citochalasin B é um alcaloide que ocorre naturalmente e é derivado de várias espécies de fungos, particularmente do gênero *Helminthosporium*. É conhecido por sua capacidade de inibir a polimerização da actina, o que interrompe a dinâmica do citoesqueleto e afeta a motilidade, divisão e forma celular. Este composto tem uma fórmula molecular de C_22H_29N_3O_5 e apresenta uma estrutura complexa que inclui um anel de lactona e múltiplos grupos funcionais. Citochalasin B é frequentemente utilizado em pesquisas biológicas para estudar processos celulares, particularmente nos campos da biologia celular e farmacologia. Seu mecanismo de ação envolve a ligação à extremidade em forma de barra dos filamentos de actina, impedindo sua elongação. Além disso, foi investigado para aplicações terapêuticas potenciais, embora seu uso seja principalmente limitado a ambientes de laboratório devido aos seus efeitos citotóxicos. Precauções de segurança são necessárias ao manusear Citochalasin B, pois pode ter efeitos significativos nas funções celulares e pode representar riscos à saúde se não for gerenciado adequadamente.

Fórmula: C₂₉H₃₇NO₅

InChI: InChI=1/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22+,23+,24?,26?,27-,29-/m1/s1

Chave InChI: InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N

SMILES: O=C1[C@]23[C@]([C@H](CC4=CC=CC=C4)N1)([C@H](C)C(=C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)CCC[C@@H](O)\C=C\C(=O)O3)[H])[H]

Sinónimos:

• (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione
• 10-fenil-7(S),20(R)-dihidroxi-16(R)-metil-24-oxa[14]citochalasa-6(12),13(E),21(E)-trieno-1,23-diona
• 16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-
• 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-
• 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5R,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, [5R-(3E,5R*,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-
• 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-trien-1,23-dion
• 7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one
• Brn 1096207
• Ccris 9284
• Hsdb 3479
• Nsc 107658
• Phomin
• Cytochalasin B
• CYTOCHALASIN B SYNTHETIC >97%
• 2h-oxacyclotetradec(2,3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13
• (7s,13e,16r,20r,21e)-0-phenyl
• CYTOCHALICINB
• cytochalasin
• CYTOCHALACINB
• cytochalasin b from drechslera dematioidea
• ,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e)-(
• 9r,12as,13s,15s,15as,16as,18as)-5
• 7,20-dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-[14]cytochalas-6(12),13,21-trien
• ,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2h-oxacyclotetrad
• CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM
• CytochalasinB from Drechslera dematioidea,Phomin
• (E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE
• 9r,12as,13s,15s,15as,16s,18as)--(5
• Cytochalasin B, froM Drechslera deMatoidea
• Cytochalasin beta,helminthosporium dematioideum
• CYTOCHALASIN B FROM HELMINTHOSPORIUM DEMATIODEUM
• Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• CYTOCHALASIN B(RG)
• CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 95.0% (HPLC)
• ,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e,e)
• CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA
• 3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-2h-oxacyclotetradec(
• (e,e)-(5s,9r,12as,13s,15s,15as,16s,18as)-16-benzyl-6,7,8,9,10,12a,13,14,15,15a
• 24-oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-1
• (7S,13E,16R,20R,21E)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione
• ec[2,3-d]isoindole-2,18(5h)-dione
• (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• Cytochalasin B from Helminthosporium dematioideum

Cytochalasin B

CAS: 14930-96-2

An actin-disrupting agent

Fórmula: C₂₉H₃₇NO₅

Cor e Forma: Powder

Peso molecular: 479.61

Ref: 02-J65342

Cytochalasin B

CAS: 14930-96-2

Cytochalasin B

Fórmula: C₂₉H₃₇NO₅

Pureza: By hplc: 99.35% (Typical Value in Batch COA)

Cor e Forma: white powder

Peso molecular: 479.60777g/mol

Ref: 54-BIC1014

Cytochalasin B

CAS: 14930-96-2

Fórmula: C₂₉H₃₇NO₅

Pureza: 95%~99%

Peso molecular: 479.617

Ref: BP-SBP03783

Cytochalasin B

CAS: 14930-96-2

Fórmula: C₂₉H₃₇NO₅

Pureza: (HPLC) ≥ 97.0%

Cor e Forma: White to off-white powder

Peso molecular: 479.61

Ref: 7W-GA2080

Cytochalasin B

Produto Controlado

CAS: 14930-96-2

Applications Cytochalasin B is a fungal metabolic toxin that preferentially damages malignant cells. Microfilament-disrupting agent which inhibites cytokinesis and produces enlarged neoplastic cells. Apoptotic agent.
References Trendowski, M. et al.: Anticanc. Res., 35, 65 (2015);

Fórmula: C₂₉H₃₅N₀₅

Cor e Forma: Neat

Peso molecular: 477.6

Ref: TR-C998680

Cytochalasin B

CAS: 14930-96-2

Blocker of the actin monomers to the actin filament

Fórmula: C₂₉H₃₇NO₅

Pureza: Min. 95%

Cor e Forma: White/Off-White Solid

Peso molecular: 479.61 g/mol

Ref: 3D-FC11288

Cytochalasin B

CAS: 14930-96-2

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Fórmula: C₂₉H₃₇NO₅

Pureza: 98.79% - ＞99.99%

Cor e Forma: Felted Needles From Acetone Powder

Peso molecular: 479.61

Ref: TM-T7097