CAS 15291-75-5

Ginkgólido A

Descrição:

Ginkgólido A é um composto natural derivado das folhas da árvore Ginkgo biloba, conhecido por seus potenciais benefícios à saúde e propriedades medicinais. Pertence a uma classe de compostos chamados terpenoides, especificamente um tipo de lactona diterpênica. Ginkgólido A é caracterizado por sua estrutura bicíclica única, que contribui para sua atividade biológica. Apresenta vários efeitos farmacológicos, incluindo propriedades neuroprotetoras, anti-inflamatórias e antioxidantes, tornando-o de interesse no estudo de doenças neurodegenerativas e aprimoramento cognitivo. Além disso, Ginkgólido A foi investigado por sua capacidade de inibir o fator ativador de plaquetas (PAF), que desempenha um papel na inflamação e trombose. O composto é tipicamente encontrado em suplementos herbais e extratos derivados de Ginkgo biloba, e seu perfil de segurança foi avaliado em vários estudos. No entanto, como muitos produtos herbais, pode interagir com outros medicamentos, portanto, recomenda-se cautela ao usá-lo em conjunto com anticoagulantes ou medicamentos antiplaquetários. No geral, Ginkgólido A representa uma área significativa de pesquisa em fitoquímica e farmacologia.

Fórmula: C₂₀H₂₄O₉

InChI: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18?,19-,20?/m1/s1

Chave InChI: InChIKey=FPUXKXIZEIDQKW-IKIFPUOBSA-N

SMILES: O[C@@]12C34[C@]5(C6([C@](O3)(OC(=O)[C@@H]6O)[H])[C@H](C(C)(C)C)C[C@]5(OC4=O)[H])C[C@@]1(OC(=O)[C@H]2C)[H]

Sinónimos:

• (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (1R,3aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• (3aR,4aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R-(1alpha,3beta,3aS*,4beta,6aalpha,7aalpha,7balpha,8alpha,10aalpha,11 aS*))-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• Bilobalide A
• Bn 52020
• [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Pureza: >98.0%(HPLC)(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 408.40

Ref: 3B-G0521

Ginkgolide A

CAS: 15291-75-5

Platelet-Activating Factor (PAF) antagonist

Fórmula: C₂₀H₂₄O₉

Peso molecular: 408.41

Ref: 02-J62384

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₀H₂₄O₉

Pureza: (HPLC) ≥98%

Cor e Forma: Powder

Peso molecular: 408.41

Ref: 11-3728S

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 408.3992

Ref: IN-DA003839

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Pureza: 97%

Peso molecular: 408.4g/mol

Ref: 54-OR1024130

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Pureza: ≥98%

Peso molecular: 408.4g/mol

Ref: 54-BUP06903

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a platelet-activating factor antagonist, it can inhibit the neurotoxicity of prions or amyloid-beta1-42, may be relevant treatments for prion or Alzheimer's diseases.Ginkgolide A has neuroprotective, and anxiolytic-like effects, it is widely used for the treatment of cardiovascular diseases and diabetic vascular complications, which might be achieved through regulating the STAT3-mediated pathway.

Fórmula: C₂₀H₂₄O₉

Pureza: 95%~99%

Peso molecular: 408.403

Ref: BP-BP0646

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A (BN-52020), from Ginkgo biloba leaves, is an active PAF antagonist with potential in treating inflammation and immune disorders.

Fórmula: C₂₀H₂₄O₉

Pureza: 98.76% - 99.81%

Cor e Forma: White Powder

Peso molecular: 408.4

Ref: TM-T2749

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Peso molecular: 408.40

Ref: 4Z-G-176003

Ginkgolide A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: Off-white powder

Peso molecular: 408.41

Ref: 7W-GP9109

Ginkgolide a

CAS: 15291-75-5

Lactone

Fórmula: C₂₀H₂₄O₉

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 408.41

Ref: 5G-89204

Ginkgolide A

Produto Controlado

CAS: 15291-75-5

Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)

Fórmula: C₂₀H₂₄O₉

Cor e Forma: Neat

Peso molecular: 408.40

Ref: TR-G387425

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a terpenoid lactone, which is a diterpene known for its presence in the leaves of the Ginkgo biloba tree. As a bioactive compound, it is naturally sourced from this ancient plant, which has been utilized in traditional medicine for centuries. Ginkgolide A acts primarily as an antagonist of platelet-activating factor (PAF), thereby influencing a range of physiological processes. Its modulatory effects on neurotransmission and vascular function arise from its ability to inhibit PAF binding to its receptor, reducing platelet aggregation and improving microcirculatory flow.

Fórmula: C₂₀H₂₄O₉

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 408.4 g/mol

Ref: 3D-FG10335

Ginkgolide Impurity A

CAS: 15291-75-5

Fórmula: C₂₀H₂₄O₉

Peso molecular: 408.40

Ref: ST-EA-CP-G15001