CAS 153-61-7

Cefalotina

Descrição:

Cefalotina é um antibiótico semissintético pertencente à classe das cefalosporinas, utilizado principalmente por suas propriedades antibacterianas. É eficaz contra uma variedade de bactérias Gram-positivas e algumas Gram-negativas, tornando-o útil no tratamento de várias infecções. O composto é caracterizado por sua estrutura de beta-lactama, que é essencial para seu mecanismo de ação, pois inibe a síntese da parede celular bacteriana. Cefalotina é tipicamente administrado por injeção e é conhecido por sua estabilidade contra certas beta-lactamases, embora não seja resistente a todos os tipos. Sua farmacocinética envolve rápida absorção e distribuição no corpo, com uma meia-vida relativamente curta, necessitando de múltiplas doses para um tratamento eficaz. Efeitos colaterais comuns podem incluir reações alérgicas, distúrbios gastrointestinais e potenciais impactos na função renal. Assim como outros antibióticos, o surgimento de resistência é uma preocupação, destacando a importância do uso apropriado em ambientes clínicos. No geral, Cefalotina continua sendo uma opção valiosa no arsenal de antibióticos, particularmente para infecções causadas por organismos suscetíveis.

Fórmula: C₁₆H₁₆N₂O₆S₂

InChI: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1

Chave InChI: InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC3=CC=CS3)=O)C2=O)(SCC1COC(C)=O)[H]

Sinónimos:

• (6R,7R)-3-(Acetoxymethyl)-8-Oxo-7-(2-(Thiophen-2-Yl)Acetamido)-5-Thia-1-Aza-Bicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
• (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R-trans)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6S,7S)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-(Acetoxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
• 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-, acetate (ester)
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-, (6R,7R)-
• 7-(2-Thienylacetamido)cephalosporanic acid
• 7-(Thiophene-2-acetamido)cephalosporin
• 7-[2-(2-Thienyl)acetylamido]cephalosporanic acid
• CT
• Cefalothin
• Cefalothin Acid
• Cefalotin
• Cefalotin Acid
• Cefalotina
• Cefalotine
• Cephalotin
• Cephalotin acid
• Ceratinine, standard solution
• Fatty acids, tall-oil, sulfonated

Cephalothin

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Orange to Green powder to crystal

Peso molecular: 396.43

Ref: 3B-C2769

Cephalothin (acid), 97%

CAS: 153-61-7

<p></p>

Fórmula: C₁₆H₁₅N₂NaO₆S₂

Pureza: 97%

Cor e Forma: Powder, White to pale cream

Peso molecular: 418.41

Ref: 02-H36175

(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 396.4380

Ref: IN-DA007HPY

Cephalothin

CAS: 153-61-7

Cephalothin

Pureza: ≥98%

Peso molecular: 396.44g/mol

Ref: 54-BUP13813

Cefalotin

CAS: 153-61-7

Cefalotin

Pureza: 97%

Peso molecular: 396.44g/mol

Ref: 54-OR1030085

Cefalotin

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: ≥ 97.0%

Cor e Forma: White to off-white powder

Peso molecular: 396.44

Ref: 7W-GA3485

Cefalotin

Produto Controlado

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Cor e Forma: Neat

Peso molecular: 396.44

Ref: 04-C11064065

Cefalonium Impurity A (Cefalotin)

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Peso molecular: 396.44

Ref: 4Z-C-229002

Cephalothin

CAS: 153-61-7

Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM).

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: 99.62%

Cor e Forma: Solid Solid

Peso molecular: 396.44

Ref: TM-T5570

Cephalothin

Produto Controlado

CAS: 153-61-7

Applications A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies.
References Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);

Fórmula: C₁₆H₁₆N₂O₆S₂

Cor e Forma: Neat

Peso molecular: 396.44

Ref: TR-C261150

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: 97%

Cor e Forma: White powder

Peso molecular: 396.43

Ref: 10-F079464

(6R,7R)-3-((4-Carbamoylpyridin-1-ium-1-yl)methyl)-7-((R)-2-hydroxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Produto Controlado

CAS: 153-61-7

Fórmula: C₂₀H₁₈N₄O₆S₂

Cor e Forma: Neat

Peso molecular: 474.51

Ref: TR-C261180

(6R,7R)-3-((4-Carbamoylpyridin-1-ium-1-yl)methyl)-7-((S)-2-hydroxy-2-(thiophen-2-yl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Produto Controlado

CAS: 153-61-7

Fórmula: C₂₀H₁₈N₄O₆S₂

Cor e Forma: Neat

Peso molecular: 474.51

Ref: TR-C261170

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 153-61-7

(6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is an antimicrobial agent that inhibits bacterial growth by binding to the penicillin binding protein (PBP), which prevents the synthesis of peptidoglycan. This drug has shown effectiveness against gram positive bacteria, including aerobacter aerogenes, as well as infectious diseases in wastewater treatment plants. It has also been demonstrated to be effective in experimental models of infection due to high resistance and cell signaling pathways. The reaction solution was analyzed by plasma mass spectrometry.

Fórmula: C₁₆H₁₆N₂O₆S₂

Pureza: Min. 98%

Cor e Forma: White Powder

Peso molecular: 396.44 g/mol

Ref: 3D-FA32097