CAS 154-93-8

carmustina

Descrição:

carmustina, com o número CAS 154-93-8, é um potente agente alquilante usado principalmente na quimioterapia do câncer. Pertence à classe das nitrosoureas, que se caracterizam pela capacidade de atravessar a barreira hematoencefálica, tornando-as eficazes no tratamento de tumores cerebrais e certas outras malignidades. carmustina é um pó cristalino branco a off-white que é solúvel em solventes orgânicos, mas tem solubilidade limitada em água. Seu mecanismo de ação envolve a formação de ligações cruzadas no DNA, que inibe a replicação e transcrição do DNA, levando, em última análise, à morte celular. carmustina é tipicamente administrado por via intravenosa e pode estar associado a vários efeitos colaterais, incluindo mielossupressão, náuseas e potenciais efeitos a longo prazo, como toxicidade pulmonar. Devido à sua reatividade e potencial para causar malignidades secundárias, o manuseio e monitoramento cuidadosos são essenciais durante seu uso. No geral, carmustina continua sendo um componente crítico nos regimes de tratamento para cânceres específicos, particularmente em casos onde outras terapias podem ser menos eficazes.

Fórmula: C₅H₉Cl₂N₃O₂

InChI: InChI=1/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

Chave InChI: InChIKey=DLGOEMSEDOSKAD-UHFFFAOYSA-N

SMILES: N(C(NCCCl)=O)(CCCl)N=O

Sinónimos:

• 1,3-Bis(2-Chloroethyl)-1-Nitroso-Urea
• 1,3-Bis(2-chlorethyl)-1-nitrosourea
• 1,3-Bis(2-chloroethyl)-1-nitrosourea
• 1,3-Bis(2-chloroethyl)nitrosourea
• 1,3-Bis(β-chloroethyl)-1-nitrosourea
• Bcnu
• Becenum
• Becenun
• BiCNU
• Carmubris
• Carmustin
• Carmustina
• Dti 015
• Fda 0345
• Gliadel
• Gliadel Wafer
• N,N'-Bis(2-chloroethyl)-N-nitrosourea
• Nitrumon
• Nsc 409962
• Sk 27702
• Sri 1720
• Urea, 1,3-bis(2-chloroethyl)-1-nitroso-
• Urea, N,N'-bis(2-chloroethyl)-N'-nitroso-
• 1,3-bis(beta-chloroethyl)-1-nitrosourea
• n,n’-bis(2-chloroethyl)-n-nitroso-ure
• nci-c04773
• bischlorethylnitrosurea
• bis(2-chloroethyl)nitrosourea
• sk27702
• bischloroethylnitrosourea
• 1,3-bis(2-chloroethyl)-1-nitroso-ure
• fda0345

Carmustine

CAS: 154-93-8

Fórmula: C₅H₉Cl₂N₃O₂

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow to Light orange powder to crystal

Peso molecular: 214.05

Ref: 3B-C2634

CARMUSTINE CRS

CAS: 154-93-8

CARMUSTINE CRS

Cor e Forma: Powder

Ref: 41-Y0002128

Carmustine

CAS: 154-93-8

Compounds with other nitrogen function, nesoi

Fórmula: C₅H₉Cl₂N₃O₂

Cor e Forma: Light Yellow Powder

Peso molecular: 213.00718

Ref: 45-1096724

1,3-Bis(2-chloroethyl)nitrosourea

CAS: 154-93-8

Fórmula: C₅H₉Cl₂N₃O₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 214.0499

Ref: IN-DA003DHD

Carmustine

CAS: 154-93-8

Fórmula: C₅H₉Cl₂N₃O₂

Peso molecular: 214.05

Ref: 4Z-C-474001

Carmustine

CAS: 154-93-8

Carmustine

Pureza: ≥98%

Peso molecular: 214.05g/mol

Ref: 54-BUP13658

Carmustine

CAS: 154-93-8

Fórmula: C₅H₉Cl₂N₃O₂

Pureza: ≥ 95.0%

Cor e Forma: Pale yellow to yellow-orange powder, amorphous solid or oily liquid

Peso molecular: 214.05

Ref: 7W-GP1721

Carmustine

CAS: 154-93-8

Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.

Fórmula: C₅H₉Cl₂N₃O₂

Pureza: 98% - 99.91%

Cor e Forma: Light Yellow Powder Physical Description Orange-Yellow Solid (Ntp 1992)

Peso molecular: 214.05

Ref: TM-T3091

Carmustine

Produto Controlado

CAS: 154-93-8

Stability Temperature Sensitive
Applications An alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),

Fórmula: C₅H₉Cl₂N₃O₂

Cor e Forma: Light Yellow To Light Orange Colour

Peso molecular: 214.05

Ref: TR-C183875

Carmustine

CAS: 154-93-8

Carmustine is a DNA alkylating agent which also cross-links DNA. As a result Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, mean it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.

Fórmula: C₅H₉Cl₂N₃O₂

Pureza: Min. 85%

Cor e Forma: Powder

Peso molecular: 214.05 g/mol

Ref: 3D-FC19817

Carmustine - Bio-X ™

CAS: 154-93-8

Carmustine is a DNA alkylating agent which also cross-links DNA. As a result, Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, means it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.

Fórmula: C₅H₉Cl₂N₃O₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 214.05 g/mol

Ref: 3D-BC164289

1,3-BIS(2-CHLOROETHYL)NITROSOUREA

CAS: 154-93-8

Pureza: 97%

Peso molecular: 214.0500031

Ref: 10-F828460

1,3-Bis(2-chloroethyl-d4)-1-nitrosourea

Produto Controlado

CAS: 154-93-8

Applications 1,3-Bis(2-chloroethyl-d4)-1-nitrosourea is a useful isotopically labeled compound of Carmustine (C183875)

Fórmula: C₅D₈HCl₂N₃O₂

Cor e Forma: Neat

Peso molecular: 222.09

Ref: TR-C183877