CAS 154127-42-1

(4S)-1,1-dióxido-3,4-diidro-4-hidroxi-2-(3-metoxipropil)-2H-Tieno[3,2-e]-1,2-tiazina-6-sulfonamida

Descrição:

A substância química conhecida como (4S)-1,1-dióxido-3,4-diidro-4-hidroxi-2-(3-metoxipropil)-2H-Tieno[3,2-e]-1,2-tiazina-6-sulfonamida, com o número CAS 154127-42-1, é um derivado de tiazina caracterizado por suas características estruturais únicas, incluindo um sistema de anel thieno[3,2-e] e um grupo funcional sulfonamida. Este composto exibe um centro quiral, indicado pela designação (4S), que contribui para sua potencial atividade biológica e propriedades farmacológicas. A presença do grupo 1,1-dióxido sugere que pode ter estabilidade e solubilidade aprimoradas. Além disso, os substituintes hidroxila e metoxipropila podem influenciar sua interação com alvos biológicos, afetando potencialmente sua eficácia e seletividade. Compostos desse tipo são frequentemente investigados por suas aplicações terapêuticas, particularmente nos campos de pesquisa antimicrobiana ou anti-inflamatória. Compreender as propriedades fisicoquímicas, como solubilidade, estabilidade e reatividade, é crucial para avaliar seus potenciais usos em química medicinal.

Fórmula: C₁₀H₁₆N₂O₆S₃

InChI: InChI=1/C10H16N2O6S3/c1-18-4-2-3-12-6-8(13)7-5-9(20(11,14)15)19-10(7)21(12,16)17/h5,8,13H,2-4,6H2,1H3,(H2,11,14,15)/t8-/m1/s1

Chave InChI: InChIKey=UHIWBQIWXWWDKT-MRVPVSSYSA-N

SMILES: O=S1(=O)C2=C(C=C(S(N)(=O)=O)S2)[C@H](O)CN1CCCOC

Sinónimos:

• (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-
• (4S)-4-hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
• (S)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-4-ol-6-sulfonamide-1,1-dioxide
• (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
• (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, (S)-
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide,3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, (4S)-
• (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-###154127-42-1
• BrinzolaMide Related CoMpound A
• 154127-42-1
• (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno-[3,2-e][1,2]thiazine-6-sulfonamide 1,1-di
• sulfonamide 1,1-dioxide
• (S)-3,4-Dihydro-4-hydroxy-2-(3-Methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonaMide-1,1-dioxid
• (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno
• (4S) -1, 1-dioxide-3, 4-dihydro-4-hydroxy-2 - (4S) -1, 1-dioxide-3, 4-dihydro-4-hydroxy-2 -
• Brinzolamide Impurity I
• -3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
• (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide
• 4-hydroxy-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonaMide 1,1-dioxide
• (S)-4-Hydroxy-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonaMide 1,1-dioxide
• (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2...
• Brinzolamide Intermediate 1
• Brinzolamide Impurity 5
• 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide,3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide
• -4-Hydroxy-2-(3-methoxypropyl)
• (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1
• (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno-[3,2-e][1,2]thiazine-6-sulfonamide 1,1

(4S)-4-Hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide

CAS: 154127-42-1

Fórmula: C₁₀H₁₆N₂O₆S₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 356.4388

Ref: IN-DA007XRL

(S)-4-Hydroxy-2-(3-Methoxypropyl)-3,4-Dihydro-2H-Thieno[3,2-E][1,2]Thiazine-6-Sulfonamide 1,1-Dioxide

CAS: 154127-42-1

(S)-4-Hydroxy-2-(3-Methoxypropyl)-3,4-Dihydro-2H-Thieno[3,2-E][1,2]Thiazine-6-Sulfonamide 1,1-Dioxide

Pureza: 98%

Peso molecular: 356.44g/mol

Ref: 54-OR1030226

Brinzolamide Impurity 30

CAS: 154127-42-1

Fórmula: C₁₀H₁₆N₂O₆S₃

Cor e Forma: White To Off-White Solid

Peso molecular: 356.43

Ref: 4Z-B-205

(4S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide

CAS: 154127-42-1

Cor e Forma: Neat

Ref: 86-MM1300.03

Brinzolamide Impurity D

CAS: 154127-42-1

Fórmula: C₁₀H₁₆N₂O₆S₃

Peso molecular: 356.44

Ref: ST-EA-CP-B17004

(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

CAS: 154127-42-1

Fórmula: C₁₀H₁₆N₂O₆S₃

Pureza: 97%

Peso molecular: 356.43

Ref: 10-F213637

(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide

Produto Controlado

CAS: 154127-42-1

Applications (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide has been used as a reactant for the preparation of Brinzolamide (AL-4862) [B677600], a topical carbonic anhydrase inhibitor.
References Conrow, R.E., et. al.: Org. Process Res. Dev., 3, 114 (1999)

Fórmula: C₁₀H₁₆N₂O₆S₃

Cor e Forma: Neat

Peso molecular: 356.44

Ref: TR-H946200