CAS 154598-52-4
:Efavirenz
Descrição:
Efavirenz é um inibidor não nucleosídico da transcriptase reversa (INNTI) utilizado principalmente no tratamento da infecção pelo HIV. É caracterizado pela sua capacidade de inibir a enzima transcriptase reversa, que é crucial para a replicação do vírus HIV. Quimicamente, Efavirenz é um composto lipofílico, o que contribui às suas propriedades farmacocinéticas, incluindo uma longa meia-vida e a capacidade de penetrar no sistema nervoso central. A substância é tipicamente administrada por via oral e muitas vezes faz parte da terapia combinada para aumentar a eficácia e reduzir o risco de resistência. Efavirenz é conhecido por seus efeitos colaterais, que podem incluir sintomas neuropsiquiátricos, erupções cutâneas e potenciais efeitos na função hepática. Seu mecanismo de ação envolve a ligação à enzima transcriptase reversa, levando à interrupção da conversão do RNA viral em DNA. O composto está classificado na Lista de Medicamentos Essenciais da Organização Mundial da Saúde, destacando sua importância na saúde global. Assim como com qualquer medicamento, o monitoramento de efeitos adversos e interações medicamentosas é essencial durante o tratamento.
Fórmula:C14H9ClF3NO2
InChI:InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
Chave InChI:InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
SMILES:C(#CC1CC1)[C@@]2(C(F)(F)F)C=3C(NC(=O)O2)=CC=C(Cl)C3
Sinónimos:- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(2-Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (S)-Efavirenz
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (S)-
- Dmp 266
- Efavuirenz
- L 743726
- Stocrin
- Ver mais sinónimos
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18 produtos.
Efavirenz
CAS:Fórmula:C14H9ClF3NO2Pureza:>98.0%(HPLC)(N)Cor e Forma:White to Almost white powder to crystalPeso molecular:315.68Efavirenz
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C14H9ClF3NO2Cor e Forma:White Off-White Yellow Pink Crystalline PowderPeso molecular:315.67 g/mol(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
CAS:Fórmula:C14H9ClF3NO2Pureza:98%Cor e Forma:SolidPeso molecular:315.6750Efavirenz
CAS:Fórmula:C14H9ClF3NO2Pureza:≥ 98.0%Cor e Forma:White to off-white crystalline powderPeso molecular:315.68Efavirenz
CAS:Efavirenz (DMP 266) is an HIV-1 inhibitor, affecting reverse transcriptase and various cytochrome P450 enzymes.Fórmula:C14H9ClF3NO2Pureza:99.2% - 99.84%Cor e Forma:White To Slightly Pink Crystalline PowderPeso molecular:315.67(S)-Efavirenz
CAS:<p>Applications A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Fórmula:C14H9ClF3NO2Cor e Forma:NeatPeso molecular:315.68Efavirenz
CAS:Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication with values of inhibition constant Ki between 2.97 to 17.60 mM in single mutation enzymes and 26.05 to 56.50 nM in double mutation. In the treatment of HIV, efavirenz has been studied in combination with emtricitabine and tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells, with an EC50 of 31.5 μM.Fórmula:C14H9ClF3NO2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:315.68 g/molEfavirenz - Bio-X ™
CAS:<p>Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, Efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication. In the treatment of HIV, Efavirenz has been studied in combination with Emtricitabine and Tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated Efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells.Efavirenz is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C14H9ClF3NO2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:315.67 g/mol(4S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-BENZOXAZIN-2-ONE
CAS:Pureza:98%Peso molecular:315.6799927(S)-7,14-Dihydroxy Efavirenz
CAS:Produto ControladoFórmula:C14H9ClF3NO4Cor e Forma:NeatPeso molecular:347.674
