CAS 154947-66-7

LL-37

Descrição:

LL-37 é um peptídeo antimicrobiano catelicidina humano (CAMP) que desempenha um papel crucial na resposta imune inata. É composto por 37 aminoácidos e é conhecido por sua atividade antimicrobiana de amplo espectro contra vários patógenos, incluindo bactérias, fungos e vírus. LL-37 exibe uma estrutura anfipática única, permitindo que interaja e desestabilize as membranas microbianas, levando à lise celular. Além disso, possui propriedades imunomoduladoras, influenciando a inflamação e os processos de cicatrização de feridas. LL-37 é produzido por várias células, incluindo neutrófilos e células epiteliais, e é encontrado em vários tecidos, particularmente durante infecções ou lesões. Sua capacidade de promover angiogênese e modular as respostas imunes o torna um assunto de interesse na pesquisa terapêutica, particularmente no contexto de feridas crônicas e infecções. No geral, LL-37 é um componente vital do sistema de defesa do hospedeiro, contribuindo para a manutenção da integridade da pele e das mucosas.

Sinónimos:

• H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
• antibacterial protein LL-37 amide
• LL-37(human)

LL-37

CAS: 154947-66-7

LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.

Fórmula: C₂₀₅H₃₄₀N₆₀O₅₃

Pureza: 96.7%

Cor e Forma: White

Peso molecular: 4493.33

Ref: 01-4042456

LL-37

CAS: 154947-66-7

Fórmula: C₂₀₇H₃₄₁F₃N₆₀O₅₅

Pureza: 98%

Peso molecular: 4607.2866

Ref: IN-DA00ATB8

LL-37, Human

CAS: 154947-66-7

LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

Fórmula: C₂₀₅H₃₄₀N₆₀O₅₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 4493.26

Ref: TM-TP1775

LL-37 ( Human)

CAS: 154947-66-7

LL-37 is a 37 amino acid peptide that is produced by neutrophils and other leukocytes. This peptide has been shown to have anti-inflammatory properties, which may be due to its ability to bind and activate the G protein coupled receptor (GPCR) formyl peptide receptor-like 1 (FPRL1), leading to inhibition of the production of inflammatory mediators such as IL-8. LL-37 also binds to ion channels, which may lead to membrane depolarization, thereby blocking calcium influx into the cell. LL-37 has been shown to inhibit the activation of T cells by inhibiting T cell receptor signaling and reducing cytokine production.
LL-37 also has a high affinity for antibody binding sites on B cells and macrophages and can bind with high specificity to IgE on mast cells, leading to inhibition of mast cell degranulation. The binding of LL-37 with these receptors leads to reduced inflammation in tissues, which may

Fórmula: C₂₀₅H₃₄₀N₆₀O₅₃

Pureza: Min. 95%

Peso molecular: 4,493.3 g/mol

Ref: 3D-PLL-4445-S

Cathelicidin LL 37

CAS: 154947-66-7

LL-37 is a potent antimicrobial peptide that has been shown to be effective against cancer cells and is currently being investigated as a potential antineoplastic agent. LL-37 binds to the leukocyte receptor, which leads to chemotaxis, increased expression of p53 and apoptosis. LL-37 also induces apoptotic cell death in epithelial tissues, both in vitro and in vivo. This peptide has been shown to induce death in cancer cells, as well as cell death in other types of cells.

Fórmula: C₂₀₅H₃₄₀N₆₀O₅₃

Pureza: Min. 95%

Peso molecular: 4,493.27 g/mol

Ref: 3D-FL110043