CAS 155213-67-5

Ritonavir

Descrição:

Ritonavir é um medicamento antirretroviral utilizado principalmente no tratamento do HIV/AIDS. Pertence à classe dos inibidores da protease, que atuam inibindo a enzima protease, crucial para o processo de replicação viral. Ritonavir é caracterizado por sua complexa estrutura molecular, que inclui uma série de grupos funcionais que contribuem para sua atividade farmacológica. É tipicamente administrado por via oral e é conhecido por sua capacidade de aumentar a eficácia de outros medicamentos antirretrovirais quando usado em terapia combinada. Ritonavir também é notável por seu papel no aumento da farmacocinética, onde aumenta a concentração plasmática de outros inibidores da protease, permitindo doses mais baixas e reduzindo os efeitos colaterais. A substância é relativamente estável em condições padrão, mas deve ser armazenada adequadamente para manter sua eficácia. Os efeitos colaterais comuns podem incluir distúrbios gastrointestinais, fadiga e alterações metabólicas. Devido ao seu papel significativo nos regimes de tratamento do HIV, Ritonavir tem sido um componente crítico na gestão da doença e na melhoria dos resultados dos pacientes.

Fórmula: C₄H₅NOS

InChI: InChI=1/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

Chave InChI: InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N

SMILES: [C@H](CC1=CC=CC=C1)(C[C@@H]([C@H](CC2=CC=CC=C2)NC(OCC3=CN=CS3)=O)O)NC([C@@H](NC(N(CC=4N=C(C(C)C)SC4)C)=O)[C@H](C)C)=O

Sinónimos:

• 1,3-Thiazol-5-Ylmethyl N-[(2S,3S,5R)-3-Hydroxy-5-[[(2S)-3-Methyl-2-[[Methyl-[(2-Propan-2-Yl-1,3-Thiazol-4-Yl)Methyl]Carbamoyl]Amino]Butanoyl]Amino]-1,6-Diphenyl-Hexan-2-Yl]Carbamate
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, [5S-(5R*,8R*,10R*,11R*)]-
• 2,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
• A 84538
• Abbott 84538
• Abt 538
• Empetus
• N-[(1S,3S,4S)-1-benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl]-N~2~-(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
• N-[(2S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)valinamide
• NSC 693184
• Norvir
• Novir
• Ritomune
• Ritovir
• Viriton
• thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-ylcarbamate
• Liponavir Core
• RITONAVIR
• Ethinyl Estradiol, Powder
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-(9CI)
• THIAZOL-5-YL-METHANOL
• CHEMBRDG-BB 4050354
• Norvi
• 1,3-THIAZOL-5-YLMETHANOL
• (3S,4S,6S,9S)-4-Hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl Ester
• RARECHEM AL BD 1261
• 5-HYDROXYMETHYLTHIAZOLE

Ritonavir

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: >98.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystaline

Peso molecular: 720.95

Ref: 3B-R0116

Ritonavir

CAS: 155213-67-5

Cor e Forma: Neat

Ref: 61-FOR1034.00

RITONAVIR FOR PEAK IDENTIFICATION CRS

CAS: 155213-67-5

RITONAVIR FOR PEAK IDENTIFICATION CRS

Fórmula: C₃₇H₄₈N₆O₅S₂

Peso molecular: 720.9442

Ref: 41-Y0000706

RITONAVIR RS

CAS: 155213-67-5

RITONAVIR RS

Ref: 41-ICRS1421

Ritonavir

CAS: 155213-67-5

Ritonavir

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: 99.7%

Cor e Forma: Off-White

Peso molecular: 720.31276

Ref: 47-1210

RITONAVIR CRS

CAS: 155213-67-5

RITONAVIR CRS

Fórmula: C₃₇H₄₈N₆O₅S₂

Cor e Forma: White. Powder.

Peso molecular: 720.9442

Ref: 41-Y0000714

Ritonavir

CAS: 155213-67-5

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Fórmula: C₃₇H₄₈N₆O₅S₂

Cor e Forma: White Tan Powder

Peso molecular: 720.31276

Ref: 45-1604803

Ritonavir Related Compounds Mixture

CAS: 155213-67-5

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Cor e Forma: White Light Yellow Powder

Ref: 45-1604814

Ritonavir

CAS: 155213-67-5

Ritonavir (ABT 538) inhibits HIV-1/2 proteases; serum proteins limit it but it enhances other HIV drugs by hindering P450 degradation.

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: 99.38% - 99.96%

Cor e Forma: White Powder

Peso molecular: 720.94

Ref: TM-T1525

Ritonavir

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Cor e Forma: White To Off-White Solid

Peso molecular: 720.95

Ref: 4Z-R-271

Ritonavir

CAS: 155213-67-5

Ritonavir

Pureza: ≥98%

Peso molecular: 720.94g/mol

Ref: 54-BUP17784

Ritonavir

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 720.94

Ref: 7W-GP3714

Ritonavir

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: 98.0%

Cor e Forma: Solid

Peso molecular: 720.95

Ref: 10-F358080

Ritonavir

Produto Controlado

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Cor e Forma: Neat

Peso molecular: 720.94

Ref: 86-MM1034.00

Ritonavir

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Cor e Forma: Neat

Peso molecular: 720.94

Ref: 04-C16815300

Ritonavir

CAS: 155213-67-5

Applications A selective HIV protease inhibitor. It is a COVID19-related research product.
References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)

Fórmula: C₃₇H₄₈N₆O₅S₂

Cor e Forma: Neat

Peso molecular: 720.94

Ref: TR-R535000

Ritonavir

CAS: 155213-67-5

Ritonavir has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2. As an added functionality, ritonavir also inactivates significantly the cytochrome P4503A4 (CYP3A4) thus increasing the bioavailability or half-life of other co-administered drugs.

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: Min. 95%

Cor e Forma: White Off-White Powder

Peso molecular: 720.95 g/mol

Ref: 3D-FR16561

Ritonavir - Bio-X ™

CAS: 155213-67-5

Ritonavir is a HIV protease inhibitor. It has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2 and has been shown to be effective in controlling virus replication in humans and animals. Ritonavir works by preventing the HIV viral protease enzyme from cleaving the structural and replicative proteins produced by HIV genes such as gag and pol.

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 720.95 g/mol

Ref: 3D-BR164353

2,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-

CAS: 155213-67-5

Fórmula: C₃₇H₄₈N₆O₅S₂

Pureza: ≥98%

Cor e Forma: Solid

Peso molecular: 720.9442

Ref: IN-DA001NQ6