CAS 15839-70-0

GDP-L-fucose

Descrição:

GDP-L-fucose, ou guanosina difosfato L-fucose, é um açúcar nucleotídico que desempenha um papel crucial nos processos de glicosilação dentro das células. É um derivado da fucose, um açúcar de deoxihéxose, e está envolvido na biossíntese de glicoconjugados fucosilados, que são importantes para o reconhecimento, sinalização e adesão entre células. A estrutura de GDP-L-fucose consiste em uma porção de guanosina ligada a um grupo difosfato e a um açúcar L-fucose. Este composto é tipicamente encontrado no citoplasma das células e é utilizado por várias glicosiltransferases para transferir resíduos de fucose para moléculas aceitadoras, como glicoproteínas e glicolípidos. Sua síntese é catalisada por enzimas específicas e é essencial para o funcionamento adequado de vários processos biológicos, incluindo respostas imunológicas e vias de sinalização do desenvolvimento. Devido à sua importância biológica, GDP-L-fucose é de interesse na pesquisa relacionada à biologia celular, bioquímica e aplicações terapêuticas potenciais.

Fórmula: C₁₆H₂₅N₅O₁₅P₂

InChI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/t4-,5+,7+,8+,9+,10+,11-,14+,15+/m0/s1

Chave InChI: InChIKey=LQEBEXMHBLQMDB-JGQUBWHWSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(OP(O[C@@H]4[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O4)(=O)O)(=O)O)[C@H]1O

Sinónimos:

• 6-Deoxy-Β-L-Galactopyranosylguanosine 5'-Diphosphate
• Fucopyranose, 1→5′-ester with guanosine 5′-(trihydrogen pyrophosphate)
• GDP-<span class="text-smallcaps">L</span>-fucose
• GDP-β-<span class="text-smallcaps">L</span>-Fucose
• Gdp-Fucose
• Guanosine 5'-Diphospho-B-L-Fucose*Sodium Approx. 90
• Guanosine 5'-Diphospho-Fucose
• Guanosine 5'-Diphospho-Β-L-Fucose Sodium Salt
• Guanosine 5′-(trihydrogen diphosphate), P′-(6-deoxy-β-<span class="text-smallcaps">L</span>-galactopyranosyl) ester
• Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxy-<span class="text-smallcaps">L</span>-galactopyranosyl) ester
• Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxy-β-<span class="text-smallcaps">L</span>-galactopyranosyl) ester
• Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxygalactopyranosyl) ester
• Guanosine 5′-(trihydrogen pyrophosphate), mono-<span class="text-smallcaps">L</span>-fucosyl ester
• Guanosine 5′-diphosphate <span class="text-smallcaps">L</span>-fucose
• Guanosine 5′-pyrophosphate, <span class="text-smallcaps">L</span>-fucosyl ester
• Guanosine 5′-pyrophosphate, β-<span class="text-smallcaps">L</span>-fucopyranosyl ester
• Guanosine diphosphate fucose
• Guanosine diphosphofucose
• Guanosine pyrophosphate, <span class="text-smallcaps">L</span>-fucosyl ester
• Guanosine-5'-Diphosphate-Beta-L-Fucose, 2Na
• [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3R,4S,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)
• [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)
• [5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl 3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate (non-preferred name)
• Guanosine 5′-(trihydrogen diphosphate), P′-(6-deoxy-β-L-galactopyranosyl) ester
• Guanosine 5′-(trihydrogen pyrophosphate), mono(6-deoxy-β-L-galactopyranosyl) ester

Guanosine diphosphate fucose

CAS: 15839-70-0

Fórmula: C₁₆H₂₅N₅O₁₅P₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 589.3417

Ref: IN-DA01DQBA

GDP-L-fucose

CAS: 15839-70-0

GDP-L-fucose

Pureza: ≥98%

Peso molecular: 589.34g/mol

Ref: 54-BUP02655

GDP-L-fucose disodium salt

CAS: 15839-70-0

Fórmula: C₁₆H₂₃N₅O₁₅P₂Na₂

Pureza: ≥ 90.0%

Cor e Forma: White to off-white powder

Peso molecular: 633.31

Ref: 7W-GC7171

GDP-L-fucose

CAS: 15839-70-0

GDP-L-fucose is a nucleotide sugar widely found in fungi and plants and is involved in both the slave and secondary remedial metabolic pathways.

Fórmula: C₁₆H₂₅N₅O₁₅P₂

Pureza: 98.06%

Cor e Forma: Solid

Peso molecular: 589.34

Ref: TM-T74041

GDP-L-Fuc.2Na

CAS: 15839-70-0

Fórmula: C₁₆H₂₃N₅Na₂O₁₅P₂

Pureza: 95%~99%

Peso molecular: 633.307

Ref: BP-BP5148

GDP-L-fucose diammonium salt

CAS: 15839-70-0

GDP-L-fucose diammonium salt is a synthetase inhibitor that has been shown to inhibit the synthesis of GDP-L-fucose. This compound is also known as 5,6-dichloro-1,2,3,4-tetrahydroisoquinoline and is a secondary metabolite of the bacterium Aerobacter aerogenes. The enzyme kinetic assay was used to determine the inhibition constant for this compound. It has been shown to be active against E. coli K-12 and S. subtilis in cell culture experiments. Inhibition of GDP-L-fucose synthesis by this compound leads to reduced bacterial growth, which may be due to its interference with cell surface carbohydrate attachment or its effects on other metabolic pathways such as glycolysis and nucleotide synthesis.

Fórmula: C₁₅H₂₃N₅O₁₅P₂·N₂H₈

Pureza: Min. 95%

Peso molecular: 623.41 g/mol

Ref: 3D-MG07459

GDP-L-fucose

CAS: 15839-70-0

Pureza: 98%

Peso molecular: 589.082

Ref: 10-F987406

GDP-L-[1-13C]fucose disodium salt

CAS: 15839-70-0

Labelled substrate for fucosyltransferase

Pureza: Min. 95%

Ref: 3D-MG170098