CAS 158966-92-8

Montelucaste

Descrição:

Montelucaste é um antagonista do receptor de leucotrienos usado principalmente no manejo da asma e da rinite alérgica. Funciona inibindo a ação dos leucotrienos, que são mediadores inflamatórios que contribuem para a broncoconstrição e a produção de muco. Montelucaste é tipicamente administrado por via oral e está disponível em várias formulações, incluindo comprimidos e formas mastigáveis. A substância tem uma fórmula molecular de C35H36ClNNaO3S e um peso molecular de aproximadamente 608,2 g/mol. É caracterizada por sua alta solubilidade em água e sua estabilidade em condições normais de armazenamento. Montelucaste é geralmente bem tolerado, com efeitos colaterais comuns que incluem dor de cabeça, distúrbios gastrointestinais e, em casos raros, alterações de humor. Sua farmacocinética indica que tem uma meia-vida relativamente longa, permitindo uma dosagem uma vez ao dia. O composto é classificado como um medicamento de prescrição e é frequentemente usado como parte de um plano abrangente de manejo da asma, particularmente para pacientes que experimentam broncoconstrição induzida por exercício ou alergias sazonais.

Fórmula: C₃₅H₃₆ClNO₃S

InChI: InChI=1/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/t32-/m1/s1

Chave InChI: InChIKey=UCHDWCPVSPXUMX-TZIWLTJVSA-N

SMILES: C(S[C@H](CCC1=C(C(C)(C)O)C=CC=C1)C2=CC(/C=C/C3=NC4=C(C=C3)C=CC(Cl)=C4)=CC=C2)C5(CC(O)=O)CC5

Sinónimos:

• (1-{[(1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl)sulfanyl]methyl}cyclopropyl)acetic acid
• (2Beta,3Alpha,5Alpha,16Beta,17Beta)-3,17-Bis(Acetyloxy)-16-(1-Methylpiperidinium-1-Yl)-2-(Piperidin-1-Yl)Androstane Bromide
• (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid
• 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid
• 1-[[[(R)-1-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid
• 2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
• 2-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropyl]acetic acid
• Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-
• Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, [R-(E)]-
• Montelukas
• Velukast
• [1-[[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid
• {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
• {1-[({(1R)-1-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid

Cyclopropaneacetic acid,1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-

CAS: 158966-92-8

Fórmula: C₃₅H₃₆ClNO₃S

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 586.1832

Ref: IN-DA00AOF9

(R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)-3-(2-(2-Hydroxypropan-2-Yl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid

CAS: 158966-92-8

(R,E)-2-(1-(((1-(3-(2-(7-Chloroquinolin-2-Yl)Vinyl)Phenyl)-3-(2-(2-Hydroxypropan-2-Yl)Phenyl)Propyl)Thio)Methyl)Cyclopropyl)Acetic Acid

Pureza: 99%

Peso molecular: 586.18g/mol

Ref: 54-OR1025583

Montelukast

CAS: 158966-92-8

Montelukast

Pureza: ≥98%

Peso molecular: 586.18g/mol

Ref: 54-BUP14076

Montelukast Sodium

CAS: 151767-02-1, 158966-92-8

Fórmula: C₃₅H₃₅ClNNaO₃S

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 608.17

Ref: 3B-M2340

Montelukast

CAS: 158966-92-8

Montelukast (Singular), oral asthma med, linked to rare liver injury.

Fórmula: C₃₅H₃₆ClNO₃S

Pureza: 98.56% - >99.99%

Cor e Forma: Solid

Peso molecular: 586.18

Ref: TM-T1677

Montelukast Impurity 32

CAS: 1093746-29-2, 158966-92-8

Fórmula: C₂₉H₂₆ClNO

Peso molecular: 439.98

Ref: 4Z-M-3059

Montelukast - Bio-X ™

CAS: 158966-92-8

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
Montelukast is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₃₅H₃₆ClNO₃S

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 586.19 g/mol

Ref: 3D-BM164608

Montelukast

CAS: 158966-92-8

Leukotriene receptor antagonist

Fórmula: C₃₅H₃₆ClNO₃S

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 586.18 g/mol

Ref: 3D-FM137467

Montelukast-d6 Sodium Salt

Produto Controlado

CAS: 1093746-29-2, 151767-02-1, 158966-92-8

Fórmula: C₃₅H₂₉D₆ClNNaO₃S

Cor e Forma: Neat

Peso molecular: 614.2

Ref: TR-M568002

2’-Des(1-hydroxy-1-methylethyl)-2’-carboxy Montelukast Bissodium Salt

Produto Controlado

CAS: 158966-92-8

Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-carboxy Montelukast Bissodium Salt is an impurity of Montelukast Sodium Salt (M568000), a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.
References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 5, 283 (1995); Jones, T.R., et al.: Can. J. Physiol. Pharmacol., 73, 191 (1995); Markham, A. and Faulds, D.: Drugs, 56, 251 (1998)

Fórmula: C₃₃H₂₈ClNNa₂O₄S

Cor e Forma: Neat

Peso molecular: 616.077

Ref: TR-D290480