CAS 159519-65-0

Enfuvirtida

Descrição:

Enfuvirtida, também conhecido pelo seu código de desenvolvimento T-20, é um peptídeo sintético que funciona como um medicamento antirretroviral utilizado principalmente no tratamento da infecção por HIV. É classificado como um inibidor de fusão, o que significa que impede o vírus de entrar nas células humanas, interferindo na fusão das membranas viral e celular. Enfuvirtida é administrado por injeção subcutânea devido à sua natureza de peptídeo, o que o torna inadequado para administração oral. A substância tem uma fórmula molecular que reflete sua estrutura de peptídeo, consistindo em uma sequência de aminoácidos que contribuem para sua atividade biológica. Seu mecanismo de ação envolve a ligação à subunidade gp41 da glicoproteína de envelope do HIV, bloqueando assim as mudanças conformacionais necessárias para a entrada viral. Enfuvirtida é tipicamente usado em combinação com outros agentes antirretrovirais em pacientes com experiência em tratamento que têm opções de tratamento limitadas. Efeitos colaterais comuns podem incluir reações no local da injeção, náuseas e fadiga. No geral, Enfuvirtida representa um componente crítico no arsenal terapêutico contra o HIV, particularmente em casos de resistência a medicamentos.

Fórmula: C₂₀₄H₃₀₁N₅₁O₆₄

InChI: InChI=1/C204H301N51O64/c1-20-102(15)166(253-195(310)137(75-100(11)12)239-200(315)150(93-258)251-190(305)143(82-112-90-215-95-219-112)248-203(318)167(103(16)21-2)254-196(311)138(76-101(13)14)240-201(316)151(94-259)252-204(319)168(105(18)260)255-197(312)139(221-106(19)261)78-108-45-47-113(262)48-46-108)202(317)233-131(58-68-164(280)281)178(293)228-130(57-67-163(278)279)182(297)250-149(92-257)198(313)232-125(52-62-155(210)266)179(294)245-145(84-157(212)268)191(306)229-124(51-61-154(209)265)175(290)224-122(49-59-152(207)263)173(288)226-126(53-63-159(270)271)176(291)222-120(43-31-33-69-205)172(287)244-144(83-156(211)267)192(307)231-127(54-64-160(272)273)177(292)225-123(50-60-153(208)264)174(289)227-128(55-65-161(274)275)180(295)235-134(72-97(5)6)185(300)237-133(71-96(3)4)184(299)230-129(56-66-162(276)277)181(296)236-135(73-98(7)8)187(302)247-147(86-165(282)283)194(309)223-121(44-32-34-70-206)171(286)241-140(79-109-87-216-117-40-28-25-37-114(109)117)183(298)220-104(17)170(285)249-148(91-256)199(314)238-136(74-99(9)10)186(301)242-142(81-111-89-218-119-42-30-27-39-116(111)119)189(304)246-146(85-158(213)269)193(308)243-141(80-110-88-217-118-41-29-26-38-115(110)118)188(303)234-132(169(214)284)77-107-35-23-22-24-36-107/h22-30,35-42,45-48,87-90,95-105,120-151,166-168,216-218,256-260,262H,20-21,31-34,43-44,49-86,91-94,205-206H2,1-19H3,(H2,207,263)(H2,208,264)(H2,209,265)(H2,210,266)(H2,211,267)(H2,212,268)(H2,213,269)(H2,214,284)(H,215,219)(H,220,298)(H,221,261)(H,222,291)(H,223,309)(H,224,290)(H,225,292)(H,226,288)(H,227,289)(H,228,293)(H,229,306)(H,230,299)(H,231,307)(H,232,313)(H,233,317)(H,234,303)(H,235,295)(H,236,296)(H,237,300)(H,238,314)(H,239,315)(H,240,316)(H,241,286)(H,242,301)(H,243,308)(H,244,287)(H,245,294)(H,246,304)(H,247,302)(H,248,318)(H,249,285)(H,250,297)(H,251,305)(H,252,319)(H,253,310)(H,254,311)(H,255,312)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)/t102-,103-,104-,105+,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,166-,167-,168-/m0/s1

Sinónimos:

• T-2
• Enfuvirtide(T-20)
• Enfurvitide(T-20)
• Pentafuside
• Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH{2}
• 1-{[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-(butan-2-yl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}prolyl-N~5~-(diaminomethylidene)ornithylglycinamide
• Enfuvirtide Acetate

Enfuvirtide

CAS: 159519-65-0

Enfuvirtide is a 36 amino acid peptide corresponding to a region of gp41, the transmembrane subunit of HIV-1 envelope protein. It belongs to the therapeutic class of fusion inhibitors and acts by binding to gp41 and impeding the conformational changes in gp41 necessary for fusion of the virus with the cell.

Fórmula: C₂₀₄H₃₀₁N₅₁O₆₄

Pureza: ≥ 94%

Cor e Forma: White Powder

Peso molecular: 4491.94

Ref: 01-4062216

L-Phenylalaninamide,N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-a-glutamyl-L-a-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-asparaginyl-L-a-glutamyl-L-glutaminyl-L-a-glutamyl-L-leucyl-L-leucyl-L-a-glutamyl-L-leucyl-L-a-aspart

CAS: 159519-65-0

Fórmula: C₂₀₄H₃₀₁N₅₁O₆₄

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 4491.8760

Ref: IN-DA01DQA6

Enfuvirtide T-20

CAS: 159519-65-0

Enfuvirtide T-20

Pureza: >97.0% as determined by (Typical Value in Batch COA)

Cor e Forma: White Lyophilised Powder

Peso molecular: 4,491.88g/mol

Ref: 54-BITP1540

Enfuvirtide

CAS: 159519-65-0

Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.

Fórmula: C₂₀₄H₃₀₁N₅₁O₆₄

Pureza: 98%

Cor e Forma: White To Off-White Amorphous Solid

Peso molecular: 4491.945

Ref: TM-TP1332

Enfuvirtide

CAS: 159519-65-0

Fórmula: C₂₀₄H₃₀₁N₅₁O₆₄

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 4491.88

Ref: BP-BPPG026

Enfuvirtide

CAS: 159519-65-0

TFA salt. Enfuviritide is a bicyclic heterocycle that is used in the treatment of HIV/AIDS. It binds to the HIV-1 envelope protein, preventing it from binding to CD4+ cells and infecting them. Enfuviritide has been shown to be effective at increasing the levels of active antiretroviral therapy and has shown significant cytotoxicity against HIV-1 and other infectious viruses. This drug also inhibits viral life by binding to the viral envelope protein gp120 and preventing it from binding to CD4+ cells. However, this drug may have long-term toxicity and may cause drug interactions with other drugs that are metabolized by cytochrome P450 enzymes. Enfuviritide has inhibitory properties against a wide range of antimicrobial agents including Gram-positive bacteria, Gram-negative bacteria, fungi, protozoa, and enveloped viruses.

Fórmula: C₂₀₄H₃₀₁N₅₁O₆₄

Pureza: Min. 95%

Peso molecular: 4,491.98 g/mol

Ref: 3D-ENF-3787-PI