CAS 16009-13-5

Hemin

Descrição:

Hemin, com o número CAS 16009-13-5, é um derivado de heme que desempenha um papel significativo em vários processos bioquímicos. É caracterizado por sua aparência cristalina de marrom escuro a preto e é solúvel em solventes orgânicos como dimetilsulfóxido (DMSO) e ligeiramente solúvel em água, particularmente em pH ácido. Hemin é a forma oxidada do heme, que contém um íon de ferro coordenado a um anel de porfirina. Este composto é conhecido por sua capacidade de participar em reações redox e pode atuar como um catalisador em várias vias bioquímicas. Hemin é frequentemente utilizado em ambientes de laboratório para estudos relacionados à hemoglobina e mioglobina, bem como na síntese de outros compostos que contêm heme. Além disso, tem aplicações na medicina, particularmente no tratamento de certas porfirias, onde ajuda a regular a síntese de heme. Sua estabilidade e reatividade fazem dele um composto valioso tanto em contextos de pesquisa quanto clínicos.

Fórmula: C₃₄H₃₀ClFeN₄O₄·2H

InChI: InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13?,27-14?,28-15?,29-14-,30-15-,31-16-,32-16?;;

Chave InChI: InChIKey=BTIJJDXEELBZFS-KKXYAJQKSA-K

SMILES: [Cl-][Fe+3]123[N-]4C5=CC6=[N]1C(=CC=7[N-]2C(C=C8[N]3=C(C=C4C(C)=C5CCC([O-])=O)C(C=C)=C8C)=C(C=C)C7C)C(C)=C6CCC([O-])=O.[H+]

Sinónimos:

• 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride
• 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex
• Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron
• Chlorohemin
• Chloroprotoferriheme
• Chloroprotohemin
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-
• Ferric hemin
• Ferriheme
• Ferriheme chloride
• Ferriporphyrin chloride
• Ferriprotoporphyrin
• Ferriprotoporphyrin IX
• Ferriprotoporphyrin IX chloride
• Haemin
• Hemin
• Hemin IX
• Hemin chloride
• Hemina
• Hemine
• Iron(III) protoporphyrin chloride
• Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-
• Kjb 003
• Panhematin
• Protoferriheme
• Protohemin
• Protohemin IX
• Protohemin chloride
• Teichmann's crystals
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, dihydrogen, (SP-5-13)-
• Alkaline Hematin D-575
• UNII-743LRP9S7N
• AI3-18784
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, dihydrogen, (SP-5-13)-
• Ferrihaem
• NSC 122707
• Teichmanns crystals
• CCRIS 7061

Hemin (porcine), 97+%

CAS: 16009-13-5

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addit

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: 97+%

Cor e Forma: Dark purple or brown to black, Crystals or powder or crystalline powder

Peso molecular: 651.95

Ref: 02-A11165

Hemin

CAS: 16009-13-5

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 651.9403

Ref: IN-DA00HYL2

Hemin, 95%

CAS: 16009-13-5

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: ≥ 95.0%

Cor e Forma: Dark blue or dark green to brown-black powder

Peso molecular: 651.95

Ref: 7W-GE0624

Hemin bovine

CAS: 16009-13-5

Hemin bovine

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: 97%

Peso molecular: 651.95g/mol

Ref: 54-BI4570

Hemin

CAS: 16009-13-5

Hemin

Pureza: ≥95%

Peso molecular: 651.94g/mol

Ref: 54-BUP18540

Hemin porcine

CAS: 16009-13-5

Hemin porcine

Fórmula: C₃₄H₃₂ClFeN₄O₄

Cor e Forma: Dark Blue Powder

Peso molecular: 651.94g/mol

Ref: 54-BIH1004

Hemin

CAS: 16009-13-5

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: >95%

Cor e Forma: Dark Blue

Peso molecular: 651.94

Ref: FT-H651-9

Hemin

CAS: 16009-13-5

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: >95.0%(T)

Cor e Forma: Dark green to Dark purple to Black powder to crystal

Peso molecular: 651.95

Ref: 3B-H0008

Hemin, 98%

CAS: 16009-13-5

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: ≥ 98%

Cor e Forma: Dark blue to brown-black powder

Peso molecular: 651.95

Ref: 7W-GE9985

Hemin

CAS: 16009-13-5

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: 97.169% - 99.59%

Cor e Forma: Dark Purple Crystalline Powder

Peso molecular: 651.94

Ref: TM-T5515

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: Min. 97 Area-%

Cor e Forma: Powder

Peso molecular: 651.94 g/mol

Ref: 3D-FH16318

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: Min. 97.0 Area-%

Peso molecular: 651.94 g/mol

Ref: 3D-H-1701

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Fórmula: C₃₄H₃₂ClFeN₄O₄

Pureza: 98.0 To 100.0 Area-%

Cor e Forma: Powder

Peso molecular: 651.94 g/mol

Ref: 3D-XH181795

Hemin Chloride (Technical grade)

CAS: 16009-13-5

Applications Hemin chloride is a porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK
References Vanova, K. et al.: BMC Cancer., 16, 309 (2016); Wang, X. et al.: ACS App. Mat. Inter., 9, 25387 (2017);

Fórmula: C₃₄H₃₂ClFeN₄O₄

Cor e Forma: Neat

Peso molecular: 651.94

Ref: TR-H245648

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

CAS: 16009-13-5

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

Fórmula: Fe(C₃₄H₃₂N₄O₄)Cl

Pureza: min. 95%

Cor e Forma: black xtl.

Peso molecular: 651.95

Ref: 08-26-1480

Hemin Chloride cryst. ex. Porcine extrapure, 98%

CAS: 16009-13-5

Fórmula: C₃₄H₃₂CIFeN₄O₄

Pureza: min. 98%

Cor e Forma: Dark brownish black to dark blue to grey, Crystalline powder

Peso molecular: 651.96

Ref: SR-98457

Hemin Chloride cryst. ex. Bovine extrapure, 98%

CAS: 16009-13-5

Fórmula: C₃₄H₃₂CIFeN₄O₄

Pureza: min. 98 %

Cor e Forma: Dark brownish black, Crystalline powder

Peso molecular: 651.96

Ref: SR-78372

Hemin

CAS: 16009-13-5

Pureza: 98%

Peso molecular: 616.18

Ref: 10-F556533

Hemin-d6

Produto Controlado

CAS: 16009-13-5

Fórmula: C₃₄D₆H₂₆ClFeN₄O₄

Cor e Forma: Neat

Peso molecular: 657.977

Ref: TR-H245647