CAS 16053-52-4

1-(2'-desoxi-beta-treopentofuranosil)timina

Descrição:

1-(2'-desoxi-beta-treopentofuranosil)timina, com o número CAS 16053-52-4, é um análogo de nucleosídeo que apresenta uma base de timina ligada a um açúcar de desoxirribose. Este composto é caracterizado por sua configuração única de açúcar, especificamente a forma beta-treo, que o distingue de outros nucleosídeos. A presença da porção de desoxirribose indica que é um componente do DNA, e a base de timina contribui para seu papel na estrutura e função dos ácidos nucleicos. Este composto é de interesse na pesquisa bioquímica e farmacêutica, particularmente no estudo das interações dos ácidos nucleicos e no desenvolvimento de agentes antivirais ou anticancerígenos. Suas propriedades estruturais podem influenciar sua atividade biológica, estabilidade e interação com enzimas ou outras biomoléculas. Além disso, a modificação do componente de açúcar pode afetar a capacidade do composto de imitar nucleosídeos naturais, potencialmente impactando sua incorporação em ácidos nucleicos e sua eficácia geral em aplicações terapêuticas.

Fórmula: C₁₀H₁₄N₂O₅

InChI: InChI=1/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7-,8-/m1/s1

SMILES: Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)O)c(=O)nc1O

Sinónimos:

• 1-(2'-Deoxy-beta-D-threo-pentofuranosyl)thymine
• 1-Dpft
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-methyl-
• 1-(2-deoxypentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2'-Deoxy-beta-threopentofuranosyl)thymine
• beta-T 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil, Zidovudine impurity 6,Zidovudine impurity M
• Stavudine EP Impurity B (Zidovudine EP Impurity F)
• 1-(2'-DEOXY-SS-THREOPENTOFURANOSYL)THYMINE
• Zidovudine Impurity 6(Zidovudine EP Impurity F)
• Zidovudine EP Impurity F (Stavudine EP Impurity B)
• 1-(2-Deoxy--D-xylofuranosyl)-5-methyluracil
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-threo-pentofuranosyl)-5-methyl-
• Zidovudine EP Impurity F
• 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil
• 1-(2'-Deoxy-β-D-threo-pentofuranosyl)thymine
• 1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil
• 1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil, 3’-FddT, Alovudine
• Stavudine EP Impurity B
• 3'-β-Thymidine
• Stavudine Impurit Ⅳ: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione( 3'-β-Thymidine)
• Zidovudine impurity M
• 1-(2-Deoxy-β-D-threopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• Stavudine Impurit Ⅳ: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione( 3’-β-Thymidine)
• 1-((2R,4R,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 3’-β-Thymidine
• Thymidine 3''-Epimer
• 1-((2S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Zidovudine Impurity F

CAS: 16053-52-4

Fórmula: C₁₀H₁₄N₂O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 242.23

Ref: 4Z-Z-087

1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil

CAS: 16053-52-4

1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil is a Nucleoside Derivative - Xylo-nucleoside.

Fórmula: C₁₀H₁₄N₂O₅

Cor e Forma: Solid

Peso molecular: 242.23

Ref: TM-TNU0990

3’-β-Thymidine-d3

Produto Controlado

CAS: 16053-52-4

Applications An intermediate in the production of labelled fluorothymidine derivatives
References Roberts, G., et al.: Biochem. Pharmacol., 46, 2209 (1993), Hatano, A., et al.: Bioorg. Med. Chem., 16, 3866 (2008),

Fórmula: C₁₀H₁₁D₃N₂O₅

Cor e Forma: Neat

Peso molecular: 245.25

Ref: TR-T412007

3’-β-Thymidine

Produto Controlado

CAS: 16053-52-4

Impurity Stavudine EP Impurity B
Applications 3’-β-Thymidine (Stavudine EP Impurity B) is an intermediate in the production of fluorothymidine and phosphorylase derivatives (1,2). Stavudine is used as an antiviral agent. Reverse transcriptase inhibitor (3).
References 1. Roberta, G. et al.: Biochem. Pharmacol. 1993 Dec 14;46(12):2209-18.2. Hatano, A. et al.: Bioorg. Med. Chem. 2008 Apr 1;16(7):3866-703. Santiprabhob, J. et al.: Biomed. Res. Int. 2017;2017:7481597.

Fórmula: C₁₀H₁₄N₂O₅

Cor e Forma: Neat

Peso molecular: 242.229

Ref: TR-T412005

1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil

CAS: 16053-52-4

1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil (1DXP) is a nucleoside that inhibits the enzyme UDP glucose pyrophosphorylase. This enzyme is involved in the synthesis of uridine nucleotides, which are required for RNA and DNA synthesis. 1DXP has been shown to be effective against hepatitis B virus and lymphocytic leukemia cells in vitro. The mechanism of action of 1DXP is not well understood, but it may be related to the inhibition of protein synthesis or cellular metabolism. It may also inhibit the enzyme amino transferase, which is important for the synthesis of aromatic amino acids such as phenylalanine and tyrosine.

Fórmula: C₁₀H₁₄N₂O₅

Pureza: Min. 95%

Peso molecular: 242.23 g/mol

Ref: 3D-ID144724

Zidovudine EP Impurity F

CAS: 16053-52-4

Fórmula: C₁₀H₁₄N₂O₅

Peso molecular: 242.23

Ref: ST-EA-CP-Z6006