CAS 160844-75-7

Etil 2-[3-ciano-4-(2-metilpropoxi)fenil]-4-metil-5-tiazolecarboxilato

Descrição:

Etil 2-[3-ciano-4-(2-metilpropoxi)fenil]-4-metil-5-tiazolecarboxilato, com número CAS 160844-75-7, é um composto orgânico sintético caracterizado por sua estrutura complexa, que inclui um anel de tiazol, um grupo ciano e um grupo funcional de éster etílico. Este composto tipicamente exibe propriedades associadas tanto a derivados de tiazol quanto a compostos aromáticos, como solubilidade moderada em solventes orgânicos e reatividade potencial devido à presença do grupo ciano. A parte de tiazol pode contribuir para a atividade biológica, tornando-o de interesse na pesquisa farmacêutica. Sua estrutura molecular sugere aplicações potenciais em química medicinal, particularmente no desenvolvimento de novos agentes terapêuticos. Além disso, a presença do grupo 2-metilpropóxido pode influenciar sua lipofilicidade e propriedades farmacocinéticas gerais. Assim como muitos compostos orgânicos, dados de segurança e precauções de manuseio devem ser considerados, uma vez que a toxicidade específica e o impacto ambiental deste composto precisariam ser avaliados por meio de estudos empíricos.

Fórmula: C₁₈H₂₀N₂O₃S

InChI: InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3

Chave InChI: InChIKey=OGAZOYHQFBSRMC-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1SC(=NC1C)C2=CC(C#N)=C(OCC(C)C)C=C2

Sinónimos:

• 2-(3-Cyano-4-Isobutoxyphenyl)-4-Methylthiazole-5-Carboxylic Acid Ethyl Ester
• 2-[3-Cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazole Carboxylic Acid Ethyl Ester
• 5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester
• Ethyl 2-(3-Cyano-4-IsobutoxyPhenyl)-4-MethylThiazole-5-Carboxylate
• Ethyl 2-[3-Cyano-4-(2-Methylpropoxy)Phenyl]-4-Methyl-1,3-Thiazole-5-Carboxylate
• Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylate
• Febuxostat N-5
• Febuxostat intermediates-2
• Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

5-Thiazolecarboxylic acid, 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester

CAS: 160844-75-7

Fórmula: C₁₈H₂₀N₂O₃S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 344.4280

Ref: IN-DA001VEX

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS: 160844-75-7

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Pureza: 98%

Peso molecular: 344.43g/mol

Ref: 54-OR96123

Febuxostat Impurity 3

CAS: 160844-75-7

Fórmula: C₁₈H₂₀N₂O₃S

Cor e Forma: Off-White Solid

Peso molecular: 344.43

Ref: 4Z-F-3912

Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS: 160844-75-7

Fórmula: C₁₈H₂₀N₂O₃S

Pureza: >98.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 344.43

Ref: 3B-E1414

Febuxostat Ethyl Ester (2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester)

CAS: 160844-75-7

Cor e Forma: Neat

Ref: 86-MM3552.02

Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS: 160844-75-7

Applications Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

Fórmula: C₁₈H₂₀N₂O₃S

Cor e Forma: Neat

Peso molecular: 344.43

Ref: TR-E907780

Febuxostat Ethyl ester impurity

CAS: 160844-75-7

Fórmula: C₁₈H₂₀N₂O₃S

Peso molecular: 344.43

Ref: ST-EA-CP-F7011

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS: 160844-75-7

Fórmula: C₁₈H₂₀N₂O₃S

Pureza: ≥98%

Cor e Forma: Liquid, No data available.

Peso molecular: 344.43

Ref: 10-F213564

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

CAS: 160844-75-7

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate (ECIT) is a derivative of formyl that has been used as a solvent for industrial and laboratory purposes. ECIT is an amorphous substance with the chemical formula CH3COC6H2CH2COCH=N(C=O)C6H4CN. The compound has been quantified in various solvents, such as n-butyl alcohol and acetonitrile. ECIT is a colorless liquid that boils at 140° C. It has a formyl group and an alkynyl group, which are both reactive groups that can be used to synthesize other compounds. ECIT also contains two stereoisomers: the erythro isomer and the threo isomer. The erythro isomer has the structural formula of CH3COC6H2CH

Pureza: Min. 95%

Ref: 3D-FE45493