CAS 163217-70-7

(2R-trans)-5-(4-fluorofenil)-2-(1-metiletil)-N-(4-hidroxifenil)-4-fenil-1-[2-(tetraidro-4-hidroxi-6-oxo-2H-piran-2-il)-etil]-1H-pirrol-3-carboxamida

Descrição:

A substância química com o nome "(2R-trans)-5-(4-fluorofenil)-2-(1-metiletil)-N-(4-hidroxifenil)-4-fenil-1-[2-(tetraidro-4-hidroxi-6-oxo-2H-piran-2-il)-etil]-1H-pirrol-3-carboxamida" e número CAS "163217-70-7" é um composto orgânico complexo caracterizado por sua estrutura de múltiplos anéis e vários grupos funcionais. Apresenta um anel de pirrol, que é um heterociclo aromático de cinco membros, e incorpora um grupo funcional carboxamida, indicando potencial para ligações de hidrogênio e interações com alvos biológicos. A presença de um grupo fluorofenila sugere lipofilicidade aumentada e potencial para maior atividade biológica. Além disso, o composto contém grupos hidroxila, que podem contribuir para a solubilidade e reatividade. Sua estereoquímica, indicada pela configuração (2R-trans), pode influenciar suas propriedades farmacológicas e interações com sistemas biológicos. No geral, este composto provavelmente será de interesse na química medicinal, particularmente no desenvolvimento de fármacos direcionados a vias biológicas específicas.

Fórmula: C₃₃H₃₃FN₂O₅

InChI: InChI=1S/C33H33FN2O5/c1-20(2)31-30(33(40)35-24-12-14-25(37)15-13-24)29(21-6-4-3-5-7-21)32(22-8-10-23(34)11-9-22)36(31)17-16-27-18-26(38)19-28(39)41-27/h3-15,20,26-27,37-38H,16-19H2,1-2H3,(H,35,40)/t26-,27-/m1/s1

Chave InChI: InChIKey=KDJMDZSAAFACAM-KAYWLYCHSA-N

SMILES: C(NC1=CC=C(O)C=C1)(=O)C=2C(=C(N(CC[C@@H]3C[C@@H](O)CC(=O)O3)C2C(C)C)C4=CC=C(F)C=C4)C5=CC=CC=C5

Sinónimos:

• 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
• 5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
• 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, (2R-trans)-
• (2R-trans)-5-(4-Fluorophenyl)-2-(1-methylethyl)-N-(4-hydroxyphenyl)-4-phenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1H-pyrrole-3-carboxamide

4-hydroxy Atorvastatin lactone

CAS: 163217-70-7

Fórmula: C₃₃H₃₃FN₂O₅

Cor e Forma: Solid

Peso molecular: 556.6239

Ref: IN-DA001TVB

para-Hydroxy Atorvastatin Lactone

CAS: 163217-70-7

Fórmula: C₃₃H₃₃FN₂O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 556.63

Ref: 4Z-A-128

4-Hydroxy atorvastatin lactone

CAS: 163217-70-7

4-Hydroxy atorvastatin lactone is a prodrug that can be hydrolyzed to the active form, atorvastatin. It is an inhibitor of HMG-CoA reductase and has been shown to significantly lower cholesterol levels in humans. 4-Hydroxy atorvastatin lactone has been shown to have no significant drug interactions with other drugs metabolized by cytochrome P450 3A5 (CYP3A5). A pharmacokinetic study of healthy Chinese subjects showed that plasma concentrations of 4-hydroxy atorvastatin lactone increased with increasing doses. Linear ranges were observed for human liver validation studies. Pharmacokinetic parameters were determined using chromatographic science, including linearity, limit of detection, limit of quantification, and specificity. The validation study was completed using electrospray ionization mass spectrometry.

Fórmula: C₃₃H₃₃FN₂O₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 556.62 g/mol

Ref: 3D-FH23909

Atorvastatin 4-Hydroxy Lactone

CAS: 163217-70-7

Fórmula: C₃₃H₃₃FN₂O₅

Peso molecular: 556.63

Ref: ST-EA-CP-A32057