CAS 163252-36-6

clevudina

Descrição:

clevudina é um análogo de nucleosídeo antiviral principalmente investigado por seu potencial no tratamento de infecções crônicas pelo vírus da hepatite B (VHB). É caracterizado por sua semelhança estrutural com nucleosídeos que ocorrem naturalmente, o que lhe permite interferir na replicação viral. clevudina funciona inibindo a enzima polimerase viral, impedindo assim a síntese de DNA viral. Este composto é tipicamente administrado por via oral e mostrou promessas em ensaios clínicos quanto à sua eficácia e perfil de segurança. Seu mecanismo de ação envolve a incorporação seletiva no DNA viral, levando à terminação da cadeia durante a replicação. clevudina é notável por suas propriedades farmacocinéticas relativamente favoráveis, incluindo boa biodisponibilidade e uma meia-vida gerenciável. No entanto, como muitos agentes antivirais, pode estar associado a efeitos colaterais, e a resistência pode se desenvolver com o uso prolongado. Pesquisas em andamento continuam a avaliar sua eficácia a longo prazo e seu papel potencial em terapias combinadas para o VHB. No geral, clevudina representa um avanço significativo no arsenal farmacológico contra a hepatite B.

Fórmula: C₁₀H₁₃FN₂O₅

InChI: InChI=1/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1

Chave InChI: InChIKey=GBBJCSTXCAQSSJ-XQXXSGGOSA-N

SMILES: F[C@H]1[C@H](O[C@@H](CO)[C@@H]1O)N2C(=O)NC(=O)C(C)=C2

Sinónimos:

• 1-(2-Deoxy-2-fluoro-b-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2′-Deoxy-2′-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyluracil
• 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-
• 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-
• L-Fmau
• Levovir
• Clevudine
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-
• 1-(2′-Deoxy-2′-fluoro-β-L-arabinofuranosyl)-5-methyluracil
• Clevudine(Levovir)
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-BETA-L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-
• 1-(2''-DEOXY-2''-FLUORO--L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-[(2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-SS-L-ARABINOFURANOSYL)-5-METHYLURACIL
• CLEVUDINE, 1-(2'-DEOXY-2'-FLUORO-β-L-ARABINOFURANOSYL)-5-METHYLURACIL
• Clevudine USP/EP/BP
• 2'-Fluoro-5-methylarabinosyluracil
• 2'-F-2'-ara-dT

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 260.2190

Ref: IN-DA001TY5

Clevudine

CAS: 163252-36-6

Clevudine

Pureza: 98%

Peso molecular: 260.22g/mol

Ref: 54-PC108998

Clevudine

CAS: 163252-36-6

Clevudine

Pureza: ≥98%

Peso molecular: 260.22g/mol

Ref: 54-BUP06493

Clevudine

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 260.22

Ref: 7W-GP8280

Clevudine

CAS: 163252-36-6

Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 99.88% - 99.97%

Cor e Forma: Solid

Peso molecular: 260.22

Ref: TM-T6446

Clevudine

CAS: 163252-36-6

Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 260.22 g/mol

Ref: 3D-NC09470

1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 260.221

Ref: 10-F235704

Clevudine

Produto Controlado

CAS: 163252-36-6

Applications Antiviral drug, used for the treatment of Hepatitis B.
References Kwon, S., et al.: J. Virol., 84, 4494 (2010), Daga, P., et al.: Protein Sci., 19, 796 (2010),

Fórmula: C₁₀H₁₃FN₂O₅

Cor e Forma: Neat

Peso molecular: 260.22

Ref: TR-C574150