CAS 163451-81-8

Teriflunomida

Descrição:

Teriflunomida é um medicamento imunomodulador utilizado principalmente no tratamento da esclerose múltipla. É um inibidor da síntese de pirimidina que atua inibindo seletivamente a enzima diidroorotato desidrogenase, que é crucial para a proliferação de linfócitos ativados. Esse mecanismo reduz o número de linfócitos circulantes, modulando assim a resposta imunológica. Teriflunomida é caracterizado por sua meia-vida relativamente longa, permitindo a dosagem oral uma vez ao dia. O composto é tipicamente apresentado como uma mistura racêmica, sendo sua forma ativa o isômero levorotatório. Tem uma solubilidade moderada em água e é lipofílico, o que ajuda na sua absorção e distribuição no corpo. Efeitos colaterais comuns podem incluir elevações das enzimas hepáticas, distúrbios gastrointestinais e potenciais efeitos teratogênicos, exigindo monitoramento cuidadoso durante o tratamento. Devido às suas propriedades imunossupressoras, é essencial que os pacientes sejam examinados quanto a infecções e outras contraindicações antes de iniciar a terapia. No geral, Teriflunomida representa um avanço significativo no manejo de condições autoimunes, particularmente a esclerose múltipla.

Fórmula: C₁₂H₉F₃N₂O₂

InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-

Chave InChI: InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N

SMILES: C(F)(F)(F)C1=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C1

Sinónimos:

• (2Z)-2-(hydroxy{[4-(trifluoromethyl)phenyl]amino}methylidene)-3-oxobutanenitrile
• (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
• (Z)-2-Cyano-alpha'alpha'alpha-trifluoro-3-hydroxy-p-crotonotoluidide
• 2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-
• 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-
• 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (Z)-
• 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide
• A 1726
• A 77-1726
• A 771726
• A771726
• Active metabolite of leflunomide
• Aubagio
• Femorix
• Flucyamide
• Hmr 1726
• Malononitrilamide
• N-(4-Trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide
• Su 20
• Teriflunomide
• Teriflunomide [INN]

TERIFLUNOMIDE CRS

CAS: 163451-81-8

TERIFLUNOMIDE CRS

Ref: 41-Y0002247

TERIFLUNOMIDE FOR ASSAY CRS

CAS: 163451-81-8

TERIFLUNOMIDE FOR ASSAY CRS

Ref: 41-Y0002253

Leflunomide Related Compound B (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide

CAS: 163451-81-8

Nitrile function compounds, not elsewhere specified or included

Fórmula: C₁₂H₉F₃N₂O₂

Cor e Forma: White Off-White Powder

Peso molecular: 270.06161

Ref: 45-1357056

Teriflunomide

CAS: 163451-81-8

Nitrile function compounds, nesoi

Fórmula: C₁₂H₉F₃N₂O₂

Cor e Forma: White Crystalline Powder

Peso molecular: 270.06161

Ref: 45-1643951

2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-

CAS: 163451-81-8

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 270.2073

Ref: IN-DA001U44

Teriflunomide

CAS: 163451-81-8

Teriflunomide

Pureza: 99%

Peso molecular: 270.21g/mol

Ref: 54-PC109050

Leflunomide EP Impurity B (Leflunomide USP Related Compound B, Teriflunomide)

CAS: 163451-81-8

Fórmula: C₁₂H₉F₃N₂O₂

Cor e Forma: White To Off-White Solid

Peso molecular: 270.21

Ref: 4Z-L-043

Teriflunomide

CAS: 163451-81-8

Teriflunomide

Pureza: ≥98%

Peso molecular: 270.21g/mol

Ref: 54-BUP14502

Leflunomide EP Impurity B-d4 (Leflunomide USP Related Compound B-d4, Teriflunomide-d4)

CAS: 163451-81-8

Fórmula: C₁₂H₅D₄F₃N₂O₂

Cor e Forma: White To Off-White Solid

Peso molecular: 274.24

Ref: 4Z-L-044

Teriflunomide

CAS: 163451-81-8

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: >98.0%(GC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 270.21

Ref: 3B-T3287

(2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide (Teriflunomide)

Produto Controlado

CAS: 163451-81-8

Fórmula: C₁₂H₉F₃N₂O₂

Cor e Forma: Neat

Peso molecular: 270.21

Ref: 86-MM0859.02

Teriflunomide

CAS: 163451-81-8

Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis.

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: 99.54% - 99.95%

Cor e Forma: Solid

Peso molecular: 270.21

Ref: TM-T7534

Leflunomide EP Impurity B

CAS: 163451-81-8

Fórmula: C₁₂H₉F₃N₂O₂

Peso molecular: 270.21

Ref: ST-EA-CP-L12002

A77 1726 (Teriflunomide)

CAS: 163451-81-8

Impurity Leflunomide EP Impurity B
Applications A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®).
References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)

Fórmula: C₁₂H₉F₃N₂O₂

Cor e Forma: White To Off-White

Peso molecular: 270.21

Ref: TR-A771726

Teriflunomide

CAS: 163451-81-8

Pureza: 95%

Peso molecular: 270.06

Ref: 10-F554435

Teriflunomide

Produto Controlado

CAS: 163451-81-8

Inhibitor of dihydroorotate dehydrogenase; anti-inflammatory; immunomodulatory

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 270.21 g/mol

Ref: 3D-FT16895

Teriflunomide

Produto Controlado

CAS: 163451-81-8

Teriflunomide is a drug that has been clinically proven for the treatment of multiple sclerosis. It is a prodrug that is converted to its active form, teriflunomide-phosphate, in vivo. Teriflunomide inhibits the activity of matrix metalloproteinases by blocking Ca2+ channels and inhibiting Ca2+ influx into the cytosol. This blocks the degradation of extracellular matrix proteins and reduces inflammation, which may lead to long-term efficacy in autoimmune diseases such as multiple sclerosis. Teriflunomide also decreases T-cell proliferation by inhibiting integrin receptors on T cells and monoclonal antibody production.

Fórmula: C₁₂H₉F₃N₂O₂

Pureza: Min. 98 Area-%

Peso molecular: 270.21 g/mol

Ref: 3D-J-010046