CAS 163515-35-3

Clorotoxina

Descrição:

Clorotoxina é um peptídeo derivado do veneno da cobra mamba verde venenosa (Dendroaspis angusticeps). É caracterizado pelo seu pequeno tamanho e estrutura específica, que lhe permite se ligar seletivamente a certos canais iônicos, particularmente os canais de cloreto nas células. Essa ligação pode interromper as funções celulares normais, tornando Clorotoxina um assunto de interesse na pesquisa do câncer, especialmente por seu potencial uso na mira de células de glioma. A substância tem sido estudada por sua capacidade de se ligar seletivamente a células tumorais enquanto preserva as células normais, o que pode levar a novas abordagens terapêuticas. Clorotoxina também é conhecido por suas propriedades fluorescentes quando conjugado com outras moléculas, permitindo que sirva como um marcador em estudos de imagem. Seu mecanismo de ação único e especificidade o tornam uma ferramenta valiosa tanto na pesquisa básica quanto em aplicações clínicas potenciais. No entanto, devido à sua origem do veneno de cobra, considerações de segurança e éticas são fundamentais em seu uso e estudo.

Fórmula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁

Sinónimos:

• Cltx
• Cltx (Egyptian Scorpion)
• H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Nh2
• H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Nh2, (Disulfide Bonds Between Cys2 And Cys19/Cys5 And Cys28/Cys16 And Cys33/Cys20 And Cys35)
• H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Oh
• Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Nh2
• Chlorotoxin, Recombinant, Expressed
• chlorotoxin from leiurus quinquestriatus (north africa)
• CHLOROTOXIN
• Tm 601
• Chlorotoxin, >97%
• Tm601 peptide
• Chlorotoxin
• Chlorotoxin trifluoroacetate salt

Chlorotoxin

CAS: 163515-35-3

As chlorotoxin has shown a remarkable affinity for binding to tumor cells, it has been conjugated to cancer drugs or radionuclides for diagnostic or therapeutic uses.

Fórmula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Pureza: 98.8%

Peso molecular: 3995.77

Ref: 01-4079411

Chlorotoxin

CAS: 163515-35-3

As chlorotoxin targets cancer cells, it was conjugated to drugs as cisplatin or dyes.

Fórmula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Pureza: ≥ 98%

Cor e Forma: Whitish Powder

Peso molecular: 3995.77

Ref: 01-4044876

Chlorotoxin

CAS: 163515-35-3

Fórmula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 3995.7096

Ref: IN-DA00AOY8

Chlorotoxin

CAS: 163515-35-3

Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.

Fórmula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 3995.71

Ref: TM-TP1431

Chlorotoxin

CAS: 163515-35-3

Fórmula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁

Peso molecular: 4004.76

Ref: 7W-GK3925

Chlorotoxin

CAS: 163515-35-3

Chlorotoxin is an ion channel activator that is characterized by its high purity and affinity. It has been shown to bind to the acetylcholine receptor in the brain, which leads to increased levels of acetylcholine at the synapse and subsequent activation of postsynaptic neurons. Chlorotoxin also inhibits potassium channels, leading to hyperpolarization of cells and a decrease in neuronal activity. The peptide is used as a research tool for cell biology and pharmacology studies.

Fórmula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Pureza: Min. 95%

Peso molecular: 3,995.7 g/mol

Ref: 3D-PCN-4282-V

Chlorotoxin from Leiurus quinquestriatus (north Africa)

CAS: 163515-35-3

Chlorotoxin is a neurotoxic peptide that belongs to the class of macrocyclic lactones. It was originally isolated from the venom of the deathstalker scorpion, Leiurus quinquestriatus, which is found in North Africa. Chlorotoxin has potent immunosuppressive and cytotoxic effects that are mediated by its ability to bind to ion channels in cell membranes through disulfide bonds. This peptide induces apoptosis and inhibits tumor growth in mice by targeting cancer cells and inducing cell death. The chlorotoxin molecule is conjugated with a variety of molecules to increase its stability and bioavailability for delivery into cells.

Fórmula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁

Pureza: Min. 95%

Peso molecular: 4,004.76 g/mol

Ref: 3D-NGA51535

Chlorotoxin trifluoroacetate salt

CAS: 163515-35-3

Chlorotoxin trifluoroacetate salt is a chlorotoxin derivative that has been modified to be more soluble in aqueous solutions. It is used to identify skin cancer and other forms of cancer, as well as for the study of cellular function and structure. The molecule can be injected into tissue or cells, where it binds to nuclei and causes cell death. Chlorotoxin trifluoroacetate salt has minimal toxicity in humans and can be used on histological specimens with little disruption to the tissue. This reagent may also be used to target intracellular targets such as glioma cells.

Fórmula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Pureza: Min. 95%

Peso molecular: 3,995.72 g/mol

Ref: 3D-FC109715