CAS 163680-77-1

Metanossulfonato de pazufloxacina

Descrição:

O metanosulfonato de pazufloxacina é um antibiótico fluoroquinolona sintético caracterizado por sua atividade antibacteriana de amplo espectro. É utilizado principalmente no tratamento de várias infecções bacterianas, particularmente aquelas causadas por organismos Gram-negativos e alguns Gram-positivos. O composto exibe um mecanismo de ação que envolve a inibição da girase do DNA bacteriano e da topoisomerase IV, enzimas críticas para a replicação e transcrição do DNA. A pazufloxacina é conhecida por suas favoráveis propriedades farmacocinéticas, incluindo boa biodisponibilidade oral e penetração nos tecidos, o que aumenta sua eficácia terapêutica. A forma de sal de metanosulfonato melhora sua solubilidade e estabilidade, tornando-a adequada para formulação em várias formas de dosagem. Além disso, a pazufloxacina tem sido estudada por seu potencial uso no tratamento de infecções do trato respiratório e do trato urinário. Assim como outras fluoroquinolonas, pode estar associada a efeitos colaterais, incluindo distúrbios gastrointestinais e potenciais efeitos na saúde dos tendões. No geral, o metanosulfonato de pazufloxacina representa uma opção valiosa no arsenal de antibióticos, particularmente no contexto do aumento da resistência aos antibióticos.

Fórmula: C₁₇H₁₉FN₂O₇S

InChI: InChI=1/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1

Chave InChI: InChIKey=UDHGFPATQWQARM-FJXQXJEOSA-N

SMILES: O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O.S(C)(=O)(=O)O

Sinónimos:

• (3S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Methanesulfonate
• (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
• (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, monomethanesulfonate (9CI)
• Pasil
• Pazucross
• Pazufloxacin Mesilate
• Pazufloxacin Mesylate
• Pazufloxacin Methanesulfonate
• T 3762
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,
• Pazufloxacin mesilate VETRANAL
• pazufloxaxin methanesulfonate
• Pazufloxacin Monomethanesulfonate
• 2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate
• (s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)
• Pazufloxacin mesylate, Pazufloxacin methanesulfonate
• PAZUFLOXAXIN METHANESULFONATE 99%

Pazufloxacin Mesylate

CAS: 127045-41-4, 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Orange to Green powder to crystal

Peso molecular: 414.40

Ref: 3B-P1962

(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5,7,9(13),11-tetraene-11-carboxylic acid; methanesulfonic acid

CAS: 163680-77-1

Fórmula: C₁₇H₁₉FN₂O₇S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 414.4054

Ref: IN-DA001UB2

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Pureza: 99.88% - 99.93%

Cor e Forma: Crystalline Solid

Peso molecular: 414.4

Ref: TM-T1620

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Pureza: ≥98%

Peso molecular: 414.4g/mol

Ref: 54-BUP14927

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Pureza: 98%

Peso molecular: 414.4g/mol

Ref: 54-PC109200

Pazufloxacin Mesylate

CAS: 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Cor e Forma: White To Off-White Solid

Peso molecular: 318.31 96.11

Ref: 4Z-P-198001

PAZUFLOXACIN MESILATE

CAS: 163680-77-1

Pureza: 95%

Peso molecular: 414.399993896484

Ref: 10-F806744

Pazufloxacin mesylate

CAS: 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Cor e Forma: Neat

Peso molecular: 414.41

Ref: 04-C15896350

Pazufloxacin mesylate

CAS: 163680-77-1

Fórmula: C₁₆H₁₅FN₂O₄·CH₄SO₃

Peso molecular: 414.41

Ref: 7W-GA7060

Pazufloxacin Mesilate RS

CAS: 163680-77-1

Cor e Forma: White To Pale Yellow-White Solid Crystalline Powder

Ref: 2K-1112800021

Pazufloxacin mesylate

CAS: 163680-77-1

Pazufloxacin mesylate is an antimicrobial agent that inhibits bacterial growth by binding to bacterial DNA gyrase and topoisomerase IV. Pazufloxacin mesylate has been shown to have a synergistic effect with other antibiotics. It has been shown to be effective against a number of human pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae. Pazufloxacin mesylate is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. The inhibition of cell division by pazufloxacin mesilate may be due to the inhibition of rna synthesis and protein synthesis. This antibiotic also causes a decrease in locomotor activity in mice, which may be due to its ability to inhibit the release of inflammatory mediators

Fórmula: C₁₇H₁₉FN₂O₇S

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 414.41 g/mol

Ref: 3D-FP26772

Pazufloxacin Mesylate

Produto Controlado

CAS: 163680-77-1

Applications A fluorinated quinolone antibiotic. Antibacterial.
References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)

Fórmula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Cor e Forma: Neat

Peso molecular: 414.41

Ref: TR-P211000