CAS 163913-87-9

fragmento de peptídeo de glicoproteína de oligodendrócito de mielina 35-55 rato, camundongo

Descrição:

O fragmento peptídico 35-55 da glicoproteína oligodendrocítica de mielina (MOG) é um peptídeo sintético derivado da glicoproteína oligodendrocítica de mielina, que é um componente significativo da bainha de mielina no sistema nervoso central. Este peptídeo é frequentemente utilizado em pesquisas relacionadas à neuroimunologia e esclerose múltipla, pois desempenha um papel na resposta imunológica e nos processos de desmielinização. O número CAS 163913-87-9 identifica este fragmento peptídico específico, que consiste em uma sequência de aminoácidos que pode provocar uma resposta imunológica em modelos experimentais, particularmente em ratos e camundongos. As características deste peptídeo incluem sua capacidade de se ligar a receptores específicos em células imunológicas, potencialmente influenciando a ativação e proliferação de células T. Além disso, é frequentemente utilizado em estudos para entender os mecanismos de doenças autoimunes e desenvolver estratégias terapêuticas. Sua estabilidade, solubilidade e atividade biológica são fatores críticos que os pesquisadores consideram ao usar este peptídeo em ambientes experimentais.

Sinónimos:

• MOG 35-55 amide

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Rat, Mouse

CAS: 163913-87-9

For cellular and molecular biology applications

Fórmula: C₁₁₈H₁₇₇N₃₅O₂₉S

Peso molecular: 2582.0

Ref: 02-J66557

MOG (Rat, Mouse, 35-55)

CAS: 163913-87-9

Amino acids 35-55 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide.
MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS).
As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (35-55) product can be used to induce these disease states in animal models.
One-Letter Formula: MEVGWYRSPFSRVVHLYRNGK

Fórmula: C₁₁₈H₁₇₇N₃₅O₂₉S

Pureza: Min. 95%

Peso molecular: 2,581.95 g/mol

Ref: 3D-PMG-3660-PI

MOG (35-55) acid Mouse, Rat

CAS: 163913-87-9

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.  MOG may function as a cell surface receptor or cell adhesion molecule.  Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has a free carboxylic acid at the C-terminus, an amide version is also available in our catalogue.

Fórmula: C₁₁₈H₁₇₇N₃₅O₂₉S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 2,581.95 g/mol

Ref: 3D-CRB1000205