CAS 164656-23-9
:Dutasterida
Descrição:
Dutasterida é um inibidor sintético da 5-alfa-redutase, utilizado principalmente no tratamento da hiperplasia prostática benigna (HPB) e da calvície de padrão masculino. Funciona inibindo a conversão de testosterona em diidrotestosterona (DHT), um hormônio implicado no crescimento da próstata e na perda de cabelo. Dutasterida é caracterizado por sua alta lipofilicidade, permitindo que penetre efetivamente nas membranas celulares. O composto é tipicamente administrado por via oral e possui uma longa meia-vida, o que contribui para sua ação sustentada na redução dos níveis de DHT. É conhecido por seus potenciais efeitos colaterais, que podem incluir disfunção sexual, ginecomastia e alterações nos níveis de enzimas hepáticas. Além disso, devido ao seu mecanismo de ação, é contraindicado em mulheres, particularmente durante a gravidez, pois pode afetar o desenvolvimento fetal. A estrutura química de Dutasterida inclui uma espinha dorsal semelhante a um esteroide, que é essencial para sua atividade biológica. No geral, Dutasterida representa um avanço significativo no manejo de condições relacionadas à DHT.
Fórmula:C27H30F6N2O2
InChI:InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
Chave InChI:InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H]
Sinónimos:- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (5Alpha,17Beta)-N-{2,5-Bis(Trifluoromethyl)Phenyl}-3-Oxo-4-Azaandrost-L-Ene-17-Carboxamide
- (5α,17β)-N-[(2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5-androst-1-ene-17-carboxamide
- 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
- 4-Azaandrost-1-ene-17-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-, (5α,17β)-
- Avodart
- Avolve
- Gg 745
- Gi 198745
- Veltride
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Pureza (%)
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100
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50
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90
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95
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100
18 produtos.
DUTASTERIDE FOR SYSTEM SUITABILITY CRS
CAS:DUTASTERIDE FOR SYSTEM SUITABILITY CRSFórmula:C27H30F6N2O2Cor e Forma:White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.Peso molecular:528.5297Dutasteride
CAS:Adrenal cortical hormones and their derivatives nesoiFórmula:C27H30F6N2O2Cor e Forma:White Pale Yellow PowderPeso molecular:528.221151H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
CAS:Fórmula:C27H30F6N2O2Pureza:98%Cor e Forma:SolidPeso molecular:528.5297Ref: IN-DA001V0C
1g107,00€5g249,00€50gA consultar100gA consultar10mg26,00€250gA consultar100mg33,00€250mg58,00€Dutasteride
CAS:Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostaticFórmula:C27H30F6N2O2Pureza:99.58%Cor e Forma:White Crystalline SolidPeso molecular:528.53Dutasteride
CAS:Fórmula:C27H30F6N2O2Pureza:≥ 98.0%Cor e Forma:White to almost white crystalline powderPeso molecular:528.53Dutasteride-13C6
CAS:Fórmula:C2113C6H30F6N2O2Cor e Forma:White To Off-White SolidPeso molecular:534.49Dutasteride
CAS:Fórmula:C27H30F6N2O2Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:528.54Dutasteride Impurity 5
CAS:Fórmula:C27H31F6NO3Cor e Forma:White To Off-White SolidPeso molecular:531.54Dutasteride
CAS:Produto Controlado<p>Applications Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Fórmula:C27H30F6N2O2Cor e Forma:NeatPeso molecular:528.53Dutasteride - Bio-X ™
CAS:<p>Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign prostatic hyperplasia (BPH) and male pattern baldness. Dutasteride reduces prostate volume and improves symptoms of BPH by inhibiting the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone.</p>Fórmula:C27H30F6N2O2Pureza:(%) Min. 99%Cor e Forma:PowderPeso molecular:528.53 g/molDutasteride
CAS:<p>A dual irreversible inhibitor of 5α-reductase isoforms 5AR1 and 5AR2 with IC50 of 6 nM and 7 nM, respectively. It supresses the production of dihydrotestosterone and has been used for the treatment of benign prostatic hyperplasia, alopecia and hirsutism in women with polycystic ovary syndrome. In rodent models for Parkinson’s disease, Dutasteride reduced L-DOPA-induced dyskinesia without altering the therapeutic effect of L-DOPA.</p>Fórmula:C27H30F6N2O2Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:528.53 g/mol
![1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA001V0C.jpg&w=3840&q=75)
