CAS 16561-29-8

Forbol 12-miristato 13-acetato

Descrição:

Forbol 12-miristato 13-acetato (PMA) é um composto orgânico sintético derivado do produto natural forbol, que é obtido das sementes da planta Jatropha. É classificado como um éster de forbol e é conhecido por seu papel como um potente promotor de tumores e ativador da proteína quinase C (PKC). PMA é um pó cristalino branco a off-white que é solúvel em solventes orgânicos como etanol e dimetilsulfóxido (DMSO), mas tem solubilidade limitada em água. O composto exibe uma variedade de atividades biológicas, incluindo a indução da proliferação e diferenciação celular, tornando-se uma ferramenta valiosa na pesquisa do câncer e estudos de biologia celular. PMA é frequentemente usado em ambientes de laboratório para estudar vias de transdução de sinal e os mecanismos de tumorigenese. No entanto, devido aos seus potentes efeitos biológicos, deve ser manuseado com cuidado em ambientes de pesquisa. Sua estrutura química apresenta um grupo miristato e um grupo acetato, contribuindo para sua reatividade e propriedades biológicas.

Fórmula: C₃₆H₅₆O₈

InChI: InChI=1/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1

Chave InChI: InChIKey=PHEDXBVPIONUQT-RGYGYFBISA-N

SMILES: O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCCCCCCCCCCCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinónimos:

• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
• 1,6,8-Beta-Tetramethyl-L)-9A-Acetate9-Myristate
• 12-O-Tetradecanoylphorbol 13-acetate
• 12-O-Tetradecanoylphorbolacetate
• 12-O-Tetradekanoylphorbol-13-Acetat
• 12-Tetradecanoylphorbol 13-acetate
• 12-Tetradecanoylphorbol 13-monoacetate
• 12-Tetradecanoylphorbol13-Monoacetate
• 13-O-Acetylphorbol 12-myristate
• 1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.
• 4β-Phorbol 12-myristate 13-acetate
• Factor A1
• Factor A1 (croton oil)
• Factor A₁
• Factor A₁ (croton oil)
• Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-
• Nsc 262244
• PMA
• PMA (tumor promoter)
• Pd 616
• Phorbol 12-tetradecanoate 13-acetate
• Phorbol myristate acetate
• TPA
• TPA (phorbol derivative)
• Tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester
• Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-
• Tetradecanoylphorbol acetate
• β-Phorbol 12-myristate 13-acetate
• 4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
• abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
• PHORBOL (12-MYRISTOYL-13-ACETYL)
• 8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
• PHORBOL 12-MYRISTATE 13-ACETATE
• 4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
• 4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
• (1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
• 5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
• 12-TETRADECANOYL PHORBOL 13-ACETATE
• 4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
• 13-o-acetylphorbol12-myristate

Phorbol 12-myristate 13-acetate, 95%

CAS: 16561-29-8

Activates protein kinase C and promotes skin tumors in mice

Fórmula: C₃₆H₅₆O₈

Pureza: 95%

Cor e Forma: White to pale cream, Powder, film or foam, solid

Peso molecular: 616.84

Ref: 02-J63916

Tetradecanoic acid, (1aR,​1bS,​4aR,​7aS,​7bS,​8R,​9R,​9aS)​-​9a-​(acetyloxy)​-​1a,​1b,​4,​4a,​5,​7a,​7b,​8,​9,​9a-​decahydro-​4a,​7b-​dihydroxy-​3-​(hydroxymethyl)​-​1,​1,​6,​8-​tetramethyl-​5-​oxo-​1H-​cyclopropa[3,​4]​benz[1,​2-​e]​azulen-​9-​yl ester

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 616.8250

Ref: IN-DA00AOO4

Phorbol 12-myristate 13-Acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-Acetate

Pureza: 95%

Peso molecular: 616.825g/mol

Ref: 54-OR1030780

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-acetate

Pureza: ≥98%

Peso molecular: 616.83g/mol

Ref: 54-BUP08804

Phorbol 12-Myristate 13-Acetate

CAS: 16561-29-8

Phorbol 12-Myristate 13-Acetate

Fórmula: C₃₆H₅₆O₈

Pureza: 98%

Cor e Forma: amorphous solid

Peso molecular: 616.83g/mol

Ref: 54-BIP1020

Phorbol-12-Myristate-13-Acetate

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Pureza: 95%~99%

Peso molecular: 616.836

Ref: BP-BP0021

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.

Fórmula: C₃₆H₅₆O₈

Pureza: 98.55% - >99.99%

Cor e Forma: White To Off-White Solid

Peso molecular: 616.83

Ref: TM-TQ0198

Phorbol 12-myristate 13-acetate

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White to off-white solid

Peso molecular: 616.83

Ref: 7W-GK8317

4β-Phorbol 12-Myristate 13-Acetate

CAS: 16561-29-8

Fórmula: C₃₆H₅₆O₈

Cor e Forma: Neat

Peso molecular: 616.82

Ref: TR-P353475

Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

Phorbol-12-myristate-13-acetate is a phorbol ester that inhibits the activity of protein kinase C. It binds to the response element on DNA and blocks RNA synthesis, leading to cell death. Phorbol 12-myristate 13-acetate has been shown to inhibit the proliferation of human squamous cells in culture, which may be caused by its ability to inhibit the cell cycle. This drug also has been shown to inhibit the production of cytokines such as interleukin-1β and tumor necrosis factor α (TNFα) in human polymorphonuclear leukocytes (PMNLs).

Fórmula: C₃₆H₅₆O₈

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 616.83 g/mol

Ref: 3D-FP15184

Phorbol-12-myristate-13-acetate

CAS: 16561-29-8

M02249 - Phorbol-12-myristate-13-acetate

Fórmula: C₃₆H₅₆O₈

Pureza: 98%

Cor e Forma: Amorphous solid in the form of a film/foam

Peso molecular: 616.836

Ref: 10-M02249