CAS 16846-24-5

Josamicina

Descrição:

Josamicina é um antibiótico macrolídeo que é derivado principalmente da fermentação da bactéria Streptomyces narbonensis. É caracterizado pela sua capacidade de inibir a síntese de proteínas bacterianas ligando-se à subunidade ribossomal 50S, impedindo assim o crescimento de bactérias suscetíveis. Josamicina exibe um amplo espectro de atividade contra várias bactérias Gram-positivas e alguns organismos Gram-negativos, tornando-o eficaz no tratamento de infecções do trato respiratório, infecções de pele e certas doenças sexualmente transmissíveis. O composto é tipicamente administrado por via oral e é conhecido por suas favoráveis propriedades farmacocinéticas, incluindo boa penetração nos tecidos e uma meia-vida relativamente longa. Josamicina também é notável por seu baixo perfil de toxicidade, o que contribui para seu uso terapêutico. No entanto, como outros antibióticos, pode levar ao desenvolvimento de resistência a antibióticos se mal utilizado. Sua estrutura química inclui um grande anel de lactona, que é uma característica comum dos antibióticos macrolídeos, contribuindo para sua atividade biológica e estabilidade.

Fórmula: C₄₂H₆₉NO₁₅

InChI: InChI=1/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,29+,30+,31-,34?,35?,36?,37?,38+,39+,40?,41?,42?/m1/s1

Chave InChI: InChIKey=XJSFLOJWULLJQS-NGVXBBESSA-N

SMILES: O([C@@H]1[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@@H]1CC=O)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CC(C)C)=O)[C@H](C)O3)[C@@H](C)O2

Sinónimos:

• (2S,3R,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
• (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
• 6-{[6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
• Antibiotic YL 704A3
• Antibiotic YL 704A₃
• En 141
• Iosalide
• Jomybel
• Josacine
• Josamicina
• Josamina
• Josamycin solution
• Josamycine
• Kitasamycin A3
• Kitasamycin A₃
• Leucomycin A3
• Leucomycin A₃
• Leucomycin V, 3-acetate 4^B-(3-methylbutanoate)
• Leucomycin V, 3-acetate 4B-(3-methylbutanoate)
• Oxacyclohexadecane, leucomycin V deriv.
• Turimycin A5
• Turimycin A₅
• Vilprafen
• Wilprafen
• JOSAMYCIN
• turimycina5
• 3-acetate4(supb)-(3-methylbutanoate)
• Leucomycin A3 (>90%)
• [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxa
• (4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-(acetyloxy)-6-[[3,6-dideoxy-4-O-[2,6-dideoxy-3-C-methyl-4-O-(3-methylbutanoyl)-α-L-ribo-hexopyranosyl]-3-(dimethylamino)-β-D-glucopyranosyl]oxy]-10-hydroxy-5-methoxy-9,16-dimethyl-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-2-one (josamycin)
• LEUCOMYCIN V,3-AC-ETA 4B-(3-METHYLBUTANOATE)
• C12662
• (2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-
• Josamycin Standard
• 3-Acetate 4B-(3-Methylbutanoate)leucoMycin V
• JOSAMYCIN(16846-24-5)
• Leucomycin V, 3-acetate 4B-(3-methylbutanoate) (9CI)
• LEUCOMYCIN V,3-ACETA 4BETA-(3-METHYL BUTANOATE)
• kitasamycina3
• Josamycin for peak identification CRS
• antibioticyl-704a3
• JOSAMYCIN USP/EP/BP
• lucamycin
• LEUCOMYCIN V,3-ACETA 4β-(3-METHYL BUTANOATE)
• Josamycin Solution, 100ppm
• YL-704A3
• Leucomycin A3 (8CI)
• Leucomycin V 3-acetate 4''-(3-methylbutanoate)
• Pre-validation
• Josamycin for peak identification
• leucomycinv,3-acetate4(supb)-(3-methylbutanoate)
• Josamycin CRS
• Sparsentan Impurity 65
• Josamycin solution solution,1000ppm

Josamycin, 98%

CAS: 16846-24-5

Macrolide antibiotic

Fórmula: C₄₂H₆₉NO₁₅

Pureza: 98%

Cor e Forma: White, Powder

Peso molecular: 827.99

Ref: 02-J62245

JOSAMYCIN FOR PEAK IDENTIFICATION CRS

CAS: 16846-24-5

JOSAMYCIN FOR PEAK IDENTIFICATION CRS

Fórmula: C₄₂H₆₉NO₁₅

Peso molecular: 827.995

Ref: 41-Y0001315

JOSAMYCIN CRS

CAS: 16846-24-5

JOSAMYCIN CRS

Fórmula: C₄₂H₆₉NO₁₅

Cor e Forma: Added

Peso molecular: 827.995

Ref: 41-Y0000041

Leucomycin V, 3-acetate 4B-(3-methylbutanoate)

CAS: 16846-24-5

Fórmula: C₄₂H₆₉NO₁₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 827.9950

Ref: IN-DA001Y2Q

Josamycin

CAS: 16846-24-5

Fórmula: C₄₂H₆₉NO₁₅

Peso molecular: 828.01

Ref: 4Z-J-008005

JOSAMYCIN

CAS: 16846-24-5

JOSAMYCIN

Pureza: ≥90%

Peso molecular: 827.99g/mol

Ref: 54-BUP14170

(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-Hydroxy-5-Methoxy-9,16-Dimethyl-2-Oxo-7-(2-Oxoethyl)Oxacyclohexadeca-11,13-Dien-6-Yl)Oxy)-4-(Dimethylamino)-5-Hydro

CAS: 16846-24-5

(2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11E,13E,16R)-4-Acetoxy-10-Hydroxy-5-Methoxy-9,16-Dimethyl-2-Oxo-7-(2-Oxoethyl)Oxacyclohexadeca-11,13-Dien-6-Yl)Oxy)-4-(Dimethylamino)-5-Hydro

Pureza: 98%

Peso molecular: 828g/mol

Ref: 54-OR1025678

Josamycin-13C-d3

CAS: 16846-24-5

Fórmula: C₄₁₁₃CH₆₆D₃NO₁₅

Peso molecular: 832.02

Ref: 4Z-J-008006

Josamycin 1000 µg/mL in Acetonitrile

Produto Controlado

CAS: 16846-24-5

Fórmula: C₄₂H₆₉NO₁₅

Cor e Forma: Single Solution

Peso molecular: 828.00

Ref: 04-A14495000AL-1000

GB 31660.1-2019 Macrolide Antibiotics Mixture 167 100 µg/mL in Methanol

Produto Controlado

CAS: 114-07-8, 1401-69-0, 16846-24-5, 2751-09-9, 69-23-8, 8025-81-8, 81103-11-9, 83905-01-5, 93952-07-9

Cor e Forma: Mixture

Ref: 04-A50000167ME

Josamycin

CAS: 16846-24-5

Fórmula: C₄₂H₆₉NO₁₅

Peso molecular: 827.99

Ref: 7W-GA0246

JOSAMYCIN

CAS: 16846-24-5

Josamycin (EN-141) is a macrolide antibiotic exhibiting antimicrobial activity. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM.

Fórmula: C₄₂H₆₉NO₁₅

Pureza: 91.38% - 99.88%

Cor e Forma: Solid

Peso molecular: 827.99

Ref: TM-T7148

Leucomycin A3

CAS: 16846-24-5

Applications A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection.
References Osono, T. et al.: J. Antibiot., 27, 366 (1974); Kuriaki, K. et al.: Jpn. J. Antibiot., 22, 232 (1969); Tan K. et al.: Zhonghua Yiyuamganranxue Zazhi, 16, 235 (2006);

Fórmula: C₄₂H₆₉NO₁₅

Pureza: >90%

Cor e Forma: Neat

Peso molecular: 828.00

Ref: TR-L330310

Leucomycin A3

CAS: 16846-24-5

Leucomycin A3 is a macrolide antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is used for treating bacterial infections and has shown potential antiviral activity.

Fórmula: C₄₂H₆₉NO₁₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 828 g/mol

Ref: 3D-AL24876

JOSAMYCIN

CAS: 16846-24-5

Pureza: ≥95%

Peso molecular: 828.0059814

Ref: 10-F840980

Josamycin Propionate EP Impurity E

CAS: 16846-24-5

Fórmula: C₄₂H₆₉NO₁₅

Peso molecular: 828.01

Ref: ST-EA-CP-J3005

Josamycin 10 µg/mL in Acetonitrile

CAS: 16846-24-5

Fórmula: C₄₂H₆₉NO₁₅

Cor e Forma: Colourless Liquid

Peso molecular: 828.00

Ref: 04-LA14495000AL