CAS 170729-80-3

Aprepitant

Descrição:

Aprepitant é um antagonista seletivo do receptor de neuroquinina-1 (NK1), utilizado principalmente na prevenção de náuseas e vômitos associados à quimioterapia e à cirurgia. É classificado como uma pequena molécula e frequentemente administrado por via oral. Aprepitant exibe alta afinidade pelo receptor NK1, que desempenha um papel crucial na resposta emética mediada pela substância P, um neuropeptídeo envolvido na percepção da dor e na inflamação. A substância é caracterizada por sua relativamente baixa solubilidade em água, o que influencia sua formulação e biodisponibilidade. Aprepitant é tipicamente utilizado em combinação com outros agentes antieméticos para aumentar a eficácia terapêutica. Sua farmacocinética envolve extenso metabolismo no fígado, principalmente através do sistema do citocromo P450, levando a potenciais interações medicamentosas. Efeitos colaterais comuns podem incluir fadiga, tontura e distúrbios gastrointestinais. No geral, Aprepitant representa um avanço significativo no manejo de náuseas e vômitos induzidos por quimioterapia, melhorando a qualidade de vida dos pacientes em tratamento contra o câncer.

Fórmula: C₂₃H₂₁F₇N₄O₃

InChI: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

Chave InChI: InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NNC(=O)N4

Sinónimos:

• 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
• 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2R-[2α(R*),3α]]-
• 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
• 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
• Emend
• L 754030
• Mk 869
• Mk-0869

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 534.43

Ref: 3B-A3135

Aprepitant impurity standard

CAS: 170729-80-3

Aprepitant impurity standard

Cor e Forma: Off White Solid

Ref: 47-1148

APREPITANT CRS

CAS: 170729-80-3

APREPITANT CRS

Fórmula: C₂₃H₂₁F₇N₄O₃

Peso molecular: 534.4267

Ref: 41-Y0001825

Aprepitant

CAS: 170729-80-3

Aprepitant

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: 99.9%

Cor e Forma: White. To. Beige

Peso molecular: 534.15019

Ref: 47-1138

Aprepitant

CAS: 170729-80-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₂₃H₂₁F₇N₄O₃

Cor e Forma: White Off-White Powder

Peso molecular: 534.15019

Ref: 45-1041904

5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 534.4267

Ref: IN-DA0034H4

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 534.43

Ref: 4Z-A-321

Aprepitant

CAS: 170729-80-3

Aprepitant

Pureza: 99%

Peso molecular: 534.43g/mol

Ref: 54-PC109217

Aprepitant

CAS: 170729-80-3

Aprepitant

Pureza: ≥98%

Peso molecular: 534.43g/mol

Ref: 54-BUP15404

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 534.43

Ref: 7W-GP4641

Aprepitant Impurity 31

CAS: 170729-80-3

Fórmula: C₂₇H₂₄F₇NO₂

Cor e Forma: White To Off-White Solid

Peso molecular: 527.49

Ref: 4Z-A-3212

Aprepitant

Produto Controlado

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Cor e Forma: Neat

Peso molecular: 534.43

Ref: 86-MM3251.00

Aprepitant

CAS: 170729-80-3

Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: 98% - 99.68%

Cor e Forma: Off-White To Light Yellow Cyrstalline Solid

Peso molecular: 534.43

Ref: TM-T1743

Aprepitant

Produto Controlado

CAS: 170729-80-3

Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).
References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)

Fórmula: C₂₃H₂₁F₇N₄O₃

Cor e Forma: Off-White

Peso molecular: 534.43

Ref: TR-A729800

Aprepitant

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: Min. 98%

Cor e Forma: White Off-White Powder

Peso molecular: 534.43 g/mol

Ref: 3D-FA17962

Aprepitant - Bio-X ™

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: Min. 98 Area-%

Peso molecular: 534.43 g/mol

Ref: 3D-BA164216

Fosaprepitant Dimeglumine Impurity C

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Peso molecular: 534.43

Ref: ST-EA-CP-F36003