CAS 171228-49-2
:Posaconazol
Descrição:
Posaconazol é um agente antifúngico triazólico utilizado principalmente para a prevenção e tratamento de infecções fúngicas, particularmente em pacientes imunocomprometidos. Apresenta um amplo espectro de atividade contra vários fungos, incluindo espécies de Candida e Aspergillus. A estrutura química de Posaconazol possui um anel triazólico, que é crucial para seu mecanismo de ação, pois inibe a enzima lanosterol 14α-desmetilase, interrompendo a síntese de ergosterol nas membranas celulares fúngicas. Isso leva a um aumento da permeabilidade da membrana e, em última análise, à morte celular. Posaconazol é caracterizado por sua relativamente baixa solubilidade em água, o que pode afetar sua biodisponibilidade; no entanto, está disponível em várias formulações, incluindo suspensão oral e comprimidos de liberação retardada. O medicamento é metabolizado principalmente no fígado, e sua farmacocinética pode ser influenciada por fatores como a ingestão de alimentos e medicamentos concomitantes. Efeitos colaterais comuns podem incluir distúrbios gastrointestinais e elevações das enzimas hepáticas. No geral, Posaconazol é uma opção terapêutica vital no manejo de infecções fúngicas invasivas, particularmente em populações de alto risco.
Fórmula:C37H42F2N8O4
InChI:InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
Chave InChI:InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES:C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7
Sinónimos:- (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
- 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
- <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- Hydroxypropyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
- Noxafil
- Posaconazole SP
- Posaconazole for research
- Sch 56592
- D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]-
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19 produtos.
Posaconazole
CAS:Fórmula:C37H42F2N8O4Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:700.79Posaconazole
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C37H42F2N8O4Cor e Forma:White PowderPeso molecular:700.329714-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
CAS:Fórmula:C37H42F2N8O4Pureza:98%Cor e Forma:SolidPeso molecular:700.7774Posaconazole
CAS:Fórmula:C37H42F2N8O4Pureza:98.0 - 102.0 % (dry basis)Cor e Forma:White to off-white powderPeso molecular:700.78Posaconazole
CAS:Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).Fórmula:C37H42F2N8O4Pureza:99.72% - >99.99%Cor e Forma:White SolidPeso molecular:700.78Posaconazole Impurity 92
CAS:Fórmula:C14H15F2N3O2Cor e Forma:White To Off-White SolidPeso molecular:295.29Posaconazole - Bio-X ™
CAS:Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients.Fórmula:C37H42F2N8O4Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:700.78 g/molPosaconazole - Form I
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.Fórmula:C37H42F2N8O4Pureza:Min. 95%Peso molecular:700.78 g/molPosaconazole - Form III
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Fórmula:C37H42F2N8O4Pureza:Min. 95%Peso molecular:700.78 g/molPosaconazole Monodesfluoro
CAS:Produto ControladoFórmula:C21H22FN3O4SCor e Forma:NeatPeso molecular:431.481Posaconazole (Ethyl-d5)
CAS:Produto ControladoFórmula:C37D5H37F2N8O4Cor e Forma:NeatPeso molecular:705.808Posaconazole
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Fórmula:C37H42F2N8O4Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:700.78 g/mol
![4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0039KV.jpg&w=3840&q=75)
