CAS 171599-83-0

citrato de sildenafil

Descrição:

citrato de sildenafil é um composto farmacêutico conhecido principalmente por seu uso no tratamento da disfunção erétil e da hipertensão arterial pulmonar. Funciona como um inibidor seletivo da fosfodiesterase tipo 5 (PDE5), que potencializa os efeitos do óxido nítrico ao aumentar os níveis de monofosfato de guanosina cíclico (cGMP) no corpo cavernoso, levando à vasodilatação e à melhora do fluxo sanguíneo. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, tornando-a adequada para administração oral. Sua fórmula molecular é C22H30N6O4S, e tem um peso molecular de aproximadamente 474,6 g/mol. citrato de sildenafil é tipicamente administrado em forma de comprimidos, com várias dosagens disponíveis, e é conhecido por ter um início de ação relativamente rápido. Efeitos colaterais comuns podem incluir dores de cabeça, rubor e dispepsia, enquanto contraindicações incluem o uso de nitratos e certas condições cardiovasculares. No geral, citrato de sildenafil teve um impacto significativo no tratamento da disfunção erétil desde sua introdução, melhorando a qualidade de vida de muitas pessoas.

Fórmula: C₂₈H₃₈N₆O₁₁S

InChI: InChI=1/C21H28N6O4S/c1-4-6-16-18-19(25-24-16)21(28)23-20(22-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-26(3)10-12-27/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,25)(H,22,23,28)

Chave InChI: InChIKey=DEIYFTQMQPDXOT-UHFFFAOYSA-N

SMILES: O(CC)C1=C(C=C(S(=O)(=O)N2CCN(C)CC2)C=C1)C=3NC4=C(C(=O)N3)N(C)N=C4CCC.C(CC(O)=O)(CC(O)=O)(C(O)=O)O

Sinónimos:

• 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one citrate
• 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
• 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-2,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
• 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• Actra-R_x
• Alisiga
• Apodefil
• Caverta 100
• Edegra
• Granpidam
• Kamagra
• Maxifort
• Mysildecard
• Niagra Actra-R_x
• Penegra
• Piperazine, 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• Sidenafil citrate
• Sildegra
• Sildigra
• Siligra
• Sollevare
• Tonafil
• Uk 92480
• Uk 92480-10
• Vega (pharmaceutical)
• Viagra
• Vigrex
• Zenegra
• Sildenafil citrate
• 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, Citrate
• SILDENAFIL CITRATE(RG)
• uk92480-10
• 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
• SildenafilCitrate/SildenafilBaseC28H38N6O11S
• 5(2-ETHOXY-5(4-METHYLPIPERAZINE)SULPHONYLPHENYL)-1
• din-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-,2-hydroxy-1,2,3-propanetricarbo
• piperazine,1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo(4,3-d)pyrimi
• SildenafilBaseC28H38N6O11S
• 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
• SILDANAFIL CITRATE (BULK)

Sildenafil Citrate

CAS: 139755-83-2, 171599-83-0

Fórmula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 666.70

Ref: 3B-S0986

Sildenafil citrate

CAS: 171599-83-0

Cor e Forma: Neat

Ref: LP-SIL-984-CI-10

Sildenafil citrate, 1mg/ml in Methanol (as free base)

CAS: 171599-83-0

Cor e Forma: Single Solution

Ref: LP-SIL-984-CI-1LM

Sildenafil citrate

CAS: 171599-83-0

Cor e Forma: Neat

Ref: 61-FOR0254.00

SILDENAFIL FOR PEAK IDENTIFICATION CRS

CAS: 171599-83-0

SILDENAFIL FOR PEAK IDENTIFICATION CRS

Fórmula: C₂₈H₃₈N₆O₁₁S

Peso molecular: 666.6999

Ref: 41-Y0001891

SILDENAFIL CITRATE CRS

CAS: 171599-83-0

SILDENAFIL CITRATE CRS

Fórmula: C₂₈H₃₈N₆O₁₁S

Peso molecular: 666.6999

Ref: 41-Y0001578

Sildenafil Citrate

CAS: 171599-83-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Fórmula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Cor e Forma: White Off-White Crystalline Powder

Peso molecular: 474.20492

Ref: 45-1612561

Sildenafil citrate

CAS: 171599-83-0

Sildenafil citrate, a PDE5 inhibitor for erectile dysfunction and occasionally pulmonary hypertension.

Fórmula: C₂₈H₃₈N₆O₁₁S

Pureza: 99.59% - 99.97%

Cor e Forma: White Solid

Peso molecular: 666.70

Ref: TM-T0467

Sildenafil Citrate

CAS: 171599-83-0

Fórmula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Cor e Forma: White To Off-White Solid

Peso molecular: 474.58 192.12

Ref: 4Z-S-061

Sildenafil citrate

CAS: 171599-83-0

Sildenafil citrate

Pureza: ≥98%

Peso molecular: 666.7g/mol

Ref: 54-BUP17834

Sildenafil citrate

CAS: 171599-83-0

Fórmula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Pureza: ≥ 99.0% (dried basis)

Cor e Forma: White powder

Peso molecular: 666.70

Ref: 7W-GP3242

Sildenafil citrate

CAS: 171599-83-0

Fórmula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Cor e Forma: Neat

Peso molecular: 666.70

Ref: 04-C16946500

Sildenafil Citrate

CAS: 171599-83-0

Cor e Forma: Neat

Ref: 86-MM0254.00

Sildenafil Citrate

Produto Controlado

CAS: 171599-83-0

Stability Store in Freezer
Applications Sildenafil Citrate is an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996), Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998),

Fórmula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Cor e Forma: White To Off-White

Peso molecular: 666.70

Ref: TR-S435000

Sildenafil Citrate-d3

Produto Controlado

CAS: 171599-83-0

Fórmula: C₂₂H₂₇D₃N₆O₄S•(C₆H₈O₇)

Cor e Forma: Off-White

Peso molecular: 669.71

Ref: TR-S435004

Sildenafil citrate

CAS: 171599-83-0

Sildenafil is an inhibitor of phosphodiesterase type-5 (PDE-5). It is used in the treatment of erectile dysfunction. Sildenafil inhibits the enzyme phosphodiesterase type-5, which prevents the conversion of cyclic guanosine monophosphate to cyclic adenosine monophosphate, and this results in relaxation of smooth muscle cells and increased blood flow to the corpus cavernosum. The PDE-5 inhibitors are selective for human PDE-5 and do not inhibit PDEs 1, 2, 3, or 6. The inhibition of PDE-5 by sildenafil is reversible. Sildenafil has been shown to be a potent inhibitor of cyclase activity in vitro. br> The LC/MS/MS method was developed to measure the concentration of sildenafil in human serum. This analytical method provides a linear calibration curve with limits of quant

Fórmula: C₂₈H₃₈N₆O₁₁S

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 666.7 g/mol

Ref: 3D-FS27829

Sildenafil citrate - Bio-X ™

CAS: 171599-83-0

A potent selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5), thereby reducing the degradation rate of cGMP. Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension.
Sildenafil citrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₈H₃₈N₆O₁₁S

Pureza: Min. 95%

Peso molecular: 666.7 g/mol

Ref: 3D-BS164405