CAS 173334-57-1

Alisquireno

Descrição:

Alisquireno é um composto farmacêutico classificado como um inibidor direto da renina, utilizado principalmente no tratamento da hipertensão. Seu mecanismo de ação envolve a inibição da renina, uma enzima que desempenha um papel crucial no sistema renina-angiotensina-aldosterona (RAAS), que regula a pressão arterial e o equilíbrio de fluidos. Alisquireno é caracterizado por sua relativamente baixa solubilidade em água, o que pode afetar sua biodisponibilidade e absorção. O composto é tipicamente administrado por via oral e é conhecido por sua longa meia-vida, permitindo uma dosagem uma vez ao dia. Alisquireno é frequentemente utilizado isoladamente ou em combinação com outros agentes antihipertensivos para alcançar um melhor controle da pressão arterial. Efeitos colaterais comuns podem incluir distúrbios gastrointestinais, dor de cabeça e tontura. Assim como outros medicamentos que afetam o RAAS, é aconselhável ter cautela em pacientes com insuficiência renal ou aqueles que estão grávidas, pois pode representar riscos para o desenvolvimento fetal. No geral, Alisquireno representa uma abordagem nova para o manejo da hipertensão, visando as etapas iniciais da via do RAAS.

Fórmula: C₃₀H₅₃N₃O₆

InChI: InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1

Chave InChI: InChIKey=UXOWGYHJODZGMF-QORCZRPOSA-N

SMILES: O(CCCOC)C1=C(OC)C=CC(C[C@@H](C[C@@H]([C@H](C[C@H](C(NCC(C(N)=O)(C)C)=O)C(C)C)O)N)C(C)C)=C1

Sinónimos:

• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxo-propyl)-4-hydroxy-2-isopropyl-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-nonanamide hydrochloride
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide (2E)-but-2-enedioate (salt)
• (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide
• (2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide
• (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide
• (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, [αS-(αR*,γR*,δR*,ζR*)]-
• Cgp 60536
• Cgp60536B
• Enviage
• Rasilez
• Riprazo
• Spp 100
• Sprimeo
• Tekturna

5-Amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate

CAS: 173334-57-1

Fórmula: C₃₀H₅₃N₃O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 551.7583

Ref: IN-DA001YTA

Aliskiren

CAS: 173334-57-1

Aliskiren

Pureza: ≥95%

Peso molecular: 551.76g/mol

Ref: 54-BUP12969

Aliskiren

CAS: 173334-57-1

Fórmula: C₃₀H₅₃N₃O₆

Peso molecular: 551.76

Ref: 7W-GP7354

Aliskiren

CAS: 173334-57-1

Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.

Fórmula: C₃₀H₅₃N₃O₆

Pureza: 97.02%

Cor e Forma: Solid

Peso molecular: 551.76

Ref: TM-T22233

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumar ate

CAS: 173334-57-1

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumar ate is a drug that inhibits the activity of angiotensin II, which is a hormone produced by the body. It is used as monotherapy for treatment of hypertension. 5AMINO has been shown to be effective in lowering blood pressure when administered alone and has been shown to be well tolerated. For this drug, the most frequently reported adverse reactions are nausea and dizziness. This drug should not be taken with other antihypertensive drugs or nonsteroidal antiinflammatory drugs such as ibuprofen (Motrin®). In addition, patients with diabetes should monitor their blood sugar levels carefully while taking this medication.

Fórmula: C₃₀H₅₃N₃O₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 551.76 g/mol

Ref: 3D-FA134549

ALISKIREN

CAS: 173334-57-1

Pureza: 98%

Peso molecular: 551.7689819

Ref: 10-F793779