CAS 17575-22-3

lanatosídeo C

Descrição:

lanatosídeo C é um glicosídeo cardíaco, um tipo de composto que exerce um efeito inotrópico positivo, o que significa que aumenta a força das contrações do coração. É derivado da planta Digitalis lanata, comumente conhecida como dedaleira lanosa. Este composto é caracterizado por sua estrutura complexa, que inclui um núcleo esteroide e um componente de açúcar, contribuindo para sua atividade biológica. lanatosídeo C é conhecido por sua capacidade de inibir a enzima Na+/K+ ATPase, levando a um aumento nos níveis de cálcio intracelular, o que melhora a contractilidade cardíaca. É tipicamente utilizado no tratamento da insuficiência cardíaca e certas arritmias. O composto também é notável por seu índice terapêutico relativamente baixo, exigindo monitoramento cuidadoso da dosagem para evitar toxicidade. Em termos de solubilidade, lanatosídeo C é geralmente solúvel em solventes orgânicos, mas tem solubilidade limitada em água. Sua farmacocinética pode ser influenciada por fatores como idade do paciente, função renal e medicamentos concomitantes, tornando abordagens de tratamento individualizadas essenciais.

Fórmula: C₄₉H₇₆O₂₀

InChI: InChI=1/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26?,27+,28-,29?,30?,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1

Chave InChI: InChIKey=JAYAGJDXJIDEKI-PTGWOZRBSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C=3COC(=O)C3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](OC(C)=O)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinónimos:

• (3beta,5beta,12beta)-3-{[beta-D-glucopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,5beta,9xi,12beta)-3-{[hexopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,8xi,9xi,12beta)-3-{[beta-D-glucopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 3-((O beta-D-Glucopyranosyl-(1-4)-O-3beta-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12beta,14-dihydroxy-5beta-card-20(22)-enolide
• 3-{[hexopyranosyl-(1->4)-3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• Allocor
• Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-4)-O-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)- (9CI)
• Card-20(22)-enolide, 3-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Cedilanid
• Ceglunat
• Ceglunate
• Celadigal
• Celanid
• Celanide
• Celanidum
• Cetosanol
• Desacetyllanatoside
• Digilanid C
• Digilanide C
• Digilanogen C
• Glycoside obtained from the leaves of Digitalis lanata Ehrh
• Isolanid
• Isolanide
• Lanatigen C
• Lanatosid C
• Lanatosid C [German]
• Lanatoside C [INN:BAN:DCF:JAN]
• Lanatosido C
• Lanatosido C [INN-Spanish]
• Lanatosidum C
• Lanatosidum C [INN-Latin]
• Lanimerck
• Lanocide-C
• NSC 7533
• Nsc 119991
• (3β,5β,12β)-3-[(O-β-D-Glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Lanatoside C
• Lanatoside C
• Digoxin EP Impurity H
• digilanidec
• Card-20(22)-enolide, 3-[(O-b-D-glucopyranosyl-(14)-O-3-O-acetyl-2,6-dideoxy-b-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3b,5b,12b)- (9CI)
• LANATOSIDE C WHO(CRM STANDARD)
• (3β,5β,12β)-
• Digoxin EP Impurity H (Lanatoside C)
• 20(22),5BETA-CARDENOLID-3BETA,12BETA,14BETA-TRIOL 3BETA-O-BETA-D-GLUCOPYRANOSYL-(1->4)-O-BETA-D-[3-O-ACETYLDIGITOXOPYRANOSYL]-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE
• Digoxin Impurity 8(Digoxin EP Impurity H)
• Trigonin C (digoxin impurity H)
• Card-20(22)-enolide, 3-[(o-.beta.-D-glucopyranosyl-(1.fwdarw.4)-o-3-o-acetyl-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1.fwdarw.4)-o-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1.fwdarw.4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3.beta.,5.beta.,12.beta.)-
• Lanatoside C (Digoxin Impurity H)
• LANATOSIDE C 97%
• LANATOSIDE C USP/EP/BP
• LANATOSIDE C(REAGENT / STANDARD GRADE)

Lanatoside C

CAS: 17575-22-3

Lanatoside C analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₄₉H₇₆O₂₀

Pureza: (HPLC) ≥95%

Cor e Forma: Powder

Peso molecular: 985.14

Ref: 11-0817

Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 985.1157

Ref: IN-DA002164

Digoxin EP Impurity H (Lanatoside C)

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Cor e Forma: White To Off-White Solid

Peso molecular: 985.13

Ref: 4Z-D-7512

Lanatoside C

CAS: 17575-22-3

Lanatoside C

Pureza: ≥98%

Peso molecular: 985.12g/mol

Ref: 54-BUP00123

Lanatoside C

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Pureza: ≥ 95.0%

Cor e Forma: White to off-white powder

Peso molecular: 985.12

Ref: 7W-GC7353

Lanatoside C

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Pureza: 95%~99%

Peso molecular: 985.127

Ref: BP-BP0838

Lanatoside C

CAS: 17575-22-3

Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.

Fórmula: C₄₉H₇₆O₂₀

Pureza: 98.3% - >99.99%

Cor e Forma: Solid

Peso molecular: 985.12

Ref: TM-T1670

Lanatoside c

CAS: 17575-22-3

Digitalis glycoside

Fórmula: C₄₉H₇₆O₂₀

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 985.13

Ref: 5G-82573

Lanatoside C

CAS: 17575-22-3

Stability Hygroscopic
Applications Glycosides isolated from various species of Digitalis. Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Novotny, J., et al.: J. Biol. Chem., 258, 14433 (1983), Farr, C., et al.: J. Med. Chem., 45, 3257 (2002), Van Dongen, M., et al.: Drug Discov. Today, 7, 471 (2002),

Fórmula: C₄₉H₇₆O₂₀

Cor e Forma: White To Off-White

Peso molecular: 985.12

Ref: TR-L173800

Lanatoside C

CAS: 17575-22-3

Lanatoside C is a cardiac glycoside, which is a bioactive compound derived from the leaves of the plant Digitalis lanata. This compound exerts its effects primarily through inhibition of the Na⁺/K⁺-ATPase enzyme in cardiac muscle cells. By inhibiting this enzyme, Lanatoside C increases intracellular sodium levels, which indirectly leads to an increase in intracellular calcium via the sodium-calcium exchange mechanism. The elevated calcium concentrations enhance cardiac muscle contraction, thereby improving cardiac output and efficiency.

Fórmula: C₄₉H₇₆O₂₀

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 985.12 g/mol

Ref: 3D-OL09899

Digoxin EP Impurity H

CAS: 17575-22-3

Fórmula: C₄₉H₇₆O₂₀

Peso molecular: 985.1

Ref: ST-EA-CP-D1200007