CAS 1775-97-9

Flavokawain B

Descrição:

Flavokawain B é um composto natural classificado como flavokawain, que é um tipo de chalcona. É derivado principalmente da espécie de planta *Kava* (Piper methysticum), conhecida por seu uso tradicional em várias culturas por suas propriedades psicoativas. A estrutura química de Flavokawain B apresenta uma espinha dorsal de chalcona característica, que consiste em dois anéis aromáticos conectados por um sistema carbonílico α,β-insaturado de três carbonos. Este composto exibe uma variedade de atividades biológicas, incluindo propriedades anti-inflamatórias, antioxidantes e potenciais anticancerígenas, tornando-se um tema de interesse na pesquisa farmacológica. Flavokawain B também é notado por sua capacidade de modular várias vias celulares, o que pode contribuir para seus efeitos terapêuticos. Sua solubilidade e estabilidade podem variar dependendo do solvente e das condições ambientais, influenciando sua biodisponibilidade e eficácia em sistemas biológicos. Assim como muitos compostos naturais, mais estudos são necessários para elucidar completamente seus mecanismos de ação e aplicações potenciais na medicina.

Fórmula: C₁₇H₁₆O₄

InChI: InChI=1S/C17H16O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-11,19H,1-2H3/b9-8+

Chave InChI: InChIKey=QKQLSQLKXBHUSO-CMDGGOBGSA-N

SMILES: C(/C=C/C1=CC=CC=C1)(=O)C2=C(OC)C=C(OC)C=C2O

Sinónimos:

• (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
• (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
• (E)-1-(2-Hydroxy-4,6-Dimethoxy-Phenyl)-3-Phenyl-Propenone
• (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-
• (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
• (E)-2′-Hydroxy-4′,6′-dimethoxychalcone
• 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-Phenyl-2-Propen-1-One)
• 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-
• 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-
• Cardamonin-4'-Methyl Ether
• Chalcone, 2′-hydroxy-4′,6′-dimethoxy-
• Dimethoxy-2'-Hydroxychalcone, 4',6'-
• Flavokavain B
• Flavokavin B
• Flavokawain B
• Flavokawin B

Flavokawain B

CAS: 1775-97-9

Flavokawain B analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₁₇H₁₆O₄

Pureza: (HPLC) ≥95%

Cor e Forma: Powder

Peso molecular: 284.31

Ref: 11-1045

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-

CAS: 1775-97-9

Fórmula: C₁₇H₁₆O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 284.3065

Ref: IN-DA0025DP

Flavokawain B

CAS: 1775-97-9

Fórmula: C₁₇H₁₆O₄

Peso molecular: 284.31

Ref: 7W-GY4305

Flavokawain B

CAS: 1775-97-9

Flavokawain B

Pureza: ≥98%

Peso molecular: 284.31g/mol

Ref: 54-BUP00989

Flavokawain B

CAS: 1775-97-9

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. Flavokawain B has potent anti-inflammatory, and anti-cancer activities, it can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

Fórmula: C₁₇H₁₆O₄

Pureza: 95%~99%

Cor e Forma: Yellow powder

Peso molecular: 284.311

Ref: BP-BP3146

Flavokawain B

CAS: 1775-97-9

Flavokawain B inhibits NO and PGE2, causes oxidative stress, and induces apoptosis, with potential for treating prostate cancer.

Fórmula: C₁₇H₁₆O₄

Pureza: 99.97% - >99.99%

Cor e Forma: Solid

Peso molecular: 284.31

Ref: TM-T6S0735

Flavokawain b

CAS: 1775-97-9

Ketone phenol

Fórmula: C₁₇H₁₆O₄

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 284.31

Ref: 5G-83763

Flavokavain B

Produto Controlado

CAS: 1775-97-9

Applications Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models.  Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.
References Pinner, K. D., et al.: Pharmaceutical Biology (Abingdon, United Kingdom), 54, Epub ahead of print (2016); Rowe A., et al.: Phytotherapy Research, 26, 1768 (2012); Alves dos Santos, R., et al.: Journal of Chemistry, (2013)

Fórmula: C₁₇H₁₆O₄

Cor e Forma: Yellow To Dark Yellow

Peso molecular: 284.31

Ref: TR-F371025

4',6'-Dimethoxy-2'-hydroxychalcone

CAS: 1775-97-9

4',6'-Dimethoxy-2'-hydroxychalcone is a chalcone compound, which is a type of flavonoid. Flavonoids are polyphenolic compounds synthesized by plants. This particular compound is typically derived from various plant sources, where it plays a role in the plant's defense mechanisms. As a chalcone, it contains a characteristic open-chain framework that distinguishes it from other flavonoids.

Fórmula: C₁₇H₁₆O₄

Pureza: Min. 95%

Peso molecular: 284.31 g/mol

Ref: 3D-FD66669