CAS 179463-17-3

Cancidas

Descrição:

Cancidas, com o número CAS 179463-17-3, é o nome comercial do agente antifúngico caspofungina. Pertence à classe de antifúngicos chamada equinocandinas, que são conhecidas por seu mecanismo de ação que inibe a síntese de β-(1,3)-D-glucano, um componente essencial da parede celular fúngica. Essa interrupção leva à lise celular e à morte do fungo. A caspofungina é usada principalmente para tratar infecções fúngicas invasivas, particularmente aquelas causadas por espécies de Candida e Aspergillus, especialmente em pacientes imunocomprometidos. É administrada por via intravenosa e é caracterizada por seu perfil de toxicidade relativamente baixo em comparação com outros agentes antifúngicos. O medicamento é geralmente bem tolerado, com efeitos colaterais que podem incluir febre, erupção cutânea e distúrbios gastrointestinais. Sua farmacocinética envolve uma meia-vida de eliminação lenta, permitindo a dosagem uma vez ao dia. No geral, Cancidas representa uma opção crítica no manejo de infecções fúngicas graves, particularmente em pacientes que são resistentes a outras terapias antifúngicas.

Fórmula: C₅₆H₉₆N₁₀O₁₉

InChI: InChI=1/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34-,35+,36-,37+,38-,40+,41+,42+,43?,44+,45+,46+;;/m1../s1

Sinónimos:

• Caspofungin acetate
• (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate
• N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
• N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1S)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• N-{(2R,6S,9R,11R,12S,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide acetate (1:2)
• Cancidas (Caspofungin Acetate)

Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

CAS: 179463-17-3

Fórmula: C₅₄H₉₂N₁₀O₁₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1153.3651

Ref: IN-DA002711

Caspofungin Diacetate

CAS: 179463-17-3

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Cor e Forma: White To Off-White Solid

Peso molecular: 1093.34 2*60.05

Ref: 4Z-PC-155001

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate

Pureza: ≥95%

Peso molecular: 1213.42g/mol

Ref: 54-BUP06070

Caspofungin acetate

CAS: 179463-17-3

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: (HPLC) ≥ 97.0% (anhydrous basis)

Cor e Forma: White to off-white powder

Peso molecular: 1213.42

Ref: 7W-GP8659

Caspofungin Acetate

CAS: 179463-17-3

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the

Fórmula: C₅₆H₉₆N₁₀O₁₉

Pureza: 97.94% - 99.9%

Cor e Forma: White Powder

Peso molecular: 1213.42

Ref: TM-T1799

Caspofungin Acetate

CAS: 179463-17-3

Applications An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.
References Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: >90%

Cor e Forma: White To Light Yellow

Peso molecular: 1213.42

Ref: TR-C184900

Caspofungin acetate

Produto Controlado

CAS: 179463-17-3

Inhibitor of glucan synthase; antifungal compound

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: Min. 90 Area-%

Cor e Forma: Powder

Peso molecular: 1,213.42 g/mol

Ref: 3D-FC16269

Caspofungin acetate - Bio-X ™

Produto Controlado

CAS: 179463-17-3

Caspofungin is an echinocandin that belongs to the class of antifungal agents. It is used to treat Aspergillus and Candida infections. It works by inhibiting the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species.

Fórmula: C₅₂H₈₈N₁₀O₁₅·2C₂H₄O₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,213.42 g/mol

Ref: 3D-BC164293