CAS 181183-52-8
:Almotriptano malato
Descrição:
Almotriptano malato é um composto farmacêutico utilizado principalmente no tratamento de enxaquecas. Pertence à classe de medicamentos triptanos, que são especificamente projetados para aliviar os sintomas da enxaqueca agindo como agonistas nos receptores de serotonina, particularmente nos subtipos 5-HT_1B e 5-HT_1D. Essa ação leva à vasoconstrição dos vasos sanguíneos cranianos e à inibição da liberação de neuropeptídeos pró-inflamatórios. O almotriptano é caracterizado por sua relativamente alta biodisponibilidade oral e um perfil farmacocinético favorável, que inclui uma meia-vida moderada que permite um manejo eficaz dos ataques agudos de enxaqueca. A forma de sal de malato melhora sua solubilidade e estabilidade, facilitando a absorção no trato gastrointestinal. O almotriptano geralmente é bem tolerado, embora possa causar efeitos colaterais como tontura, fadiga ou sensações de formigamento. Assim como outros triptanos, é contraindicado em pacientes com certas condições cardiovasculares devido ao potencial de vasoconstrição. No geral, Almotriptano malato representa uma opção importante no arsenal terapêutico para o manejo da enxaqueca.
Fórmula:C17H25N3O2S·C4H6O5
InChI:InChI=1/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
Chave InChI:InChIKey=QHATUKWEVNMHRY-UHFFFAOYSA-N
SMILES:C(CN(C)C)C=1C=2C(NC1)=CC=C(CS(=O)(=O)N3CCCC3)C2.C(CC(O)=O)(C(O)=O)O
Sinónimos:- 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
- 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
- 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
- Almotrip forte
- Almotriptan Malate
- Almotriptan Maleate
- Almotriptanmaleate
- Axert
- Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
- Butanedioic acid, hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1)
- LAS 31416 <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-malate acid
- Las-31416 Malate
- N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
- Pnu 180638
- Pnu 180638E
- Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-, hydroxybutanedioate (1:1)
- LAS 31416 D,L-malate acid
- hydroxy-Butanedioic acid, compd.with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine(1:1)(9CI)
- N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine,compd. with 2-hydroxy-butanedioic acid
- Almotriptan
- AlMotriptan Malate (Axert)
- Amotriptan malate
- 1-[[[3-[2-(dimeth
- See: A575201
- 2-Hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
- Almotriptan Malate (200 mg)
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13 produtos.
Almotriptan Malate
CAS:Sulfonamides used as drugsFórmula:C17H25N3O2S·C4H6O5Cor e Forma:White Off-White Crystalline PowderPeso molecular:335.16675Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
CAS:Fórmula:C21H31N3O7SPureza:98%Cor e Forma:SolidPeso molecular:469.5517Almotriptan-d6 Malate
CAS:Fórmula:C17H19D6N3O2S·C4H6O5Cor e Forma:White To Off-White SolidPeso molecular:341.50 134.09Almotriptan Malate
CAS:Fórmula:C17H25N3O2S·C4H6O5Cor e Forma:Pale Yellow SolidPeso molecular:335.47 134.09Almotriptan Malate
CAS:Fórmula:C17H25N3O2S·C4H6O5Pureza:>98.0%(HPLC)Cor e Forma:White to Orange to Green powder to crystalPeso molecular:469.55Almotriptan Malate
CAS:<p>Almotriptan Malate (PNU180638), a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.</p>Fórmula:C17H25N3O2S·C4H6O5Pureza:99.95%Cor e Forma:Pale Yellow SolidPeso molecular:469.55Almotriptan malate
CAS:<p>Almotriptan malate is a serotonin 1B/1D receptor agonist that is used as an anti-migraine drug, specifically for the treatment of migraine headaches with or without aura. It has been shown to cause regression of angiogenic factors and statistically significant improvement in migraine headache frequency, severity, and duration when taken within 24 hours of onset of a migraine. Almotriptan malate can be administered by nasal spray or oral tablets. The recommended dose for adults is 25-50 mg (1-2 tablets) taken at the first sign of a headache. Almotriptan malate should not be given to people who have liver impairment or are taking sodium carbonate. Side effects may include nasal congestion, dizziness, dry mouth, nausea, vomiting, and diarrhea. Almotriptan malate should be used with caution in patients with hypertension. Almotriptan malate is contraindicated in patients who have had a stroke or transient ischemic</p>Fórmula:C17H25N3O2S•C4H6O5Pureza:Min. 95%Cor e Forma:SolidPeso molecular:469.55 g/molAlmotriptan Malate
CAS:<p>Applications Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>Fórmula:C17H25N3O2S·C4H6O5Cor e Forma:NeatPeso molecular:469.55
![Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0022QH.jpg&w=3840&q=75)
