CAS 1814891-79-6

1-[[4-(4-Chloro-3,5-dimethylphenoxy)phenyl]methyl]-6-(2-furanyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

CAS: 1814891-79-6

1-[[4-(4-Chloro-3,5-dimethylphenoxy)phenyl]methyl]-6-(2-furanyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid is a potent blocker of the Kv1.2 voltage gated potassium channel. It has been shown to inhibit the growth of breast cancer cells in vitro and in vivo, and to induce apoptosis by activating caspase 3. This drug also inhibits the activation of NFκB in human monocyte cell cultures, which may be due to its ability to inhibit the binding of nuclear factor kappa B (NFκB) to DNA.

Fórmula: C₂₇H₂₂ClN₃O₄

Pureza: Min. 95%

Peso molecular: 487.9 g/mol

Ref: 3D-PXC89179

Mcl1-IN-3

CAS: 1814891-79-6

Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.

Fórmula: C₂₇H₂₂ClN₃O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 487.93

Ref: TM-T16029