CAS 18162-48-6

cloreto de tert-butil-dimetilsililo

Descrição:

cloreto de tert-butil-dimetilsililo (cloreto de TBDMS) é um composto organossilícico caracterizado por seu uso como grupo protetor para álcoois e aminas na síntese orgânica. Apresenta um grupo tert-butilo ligado a uma porção dimetilsilila, o que melhora sua estabilidade e reatividade. O composto é tipicamente um líquido incolor a amarelo pálido com um odor pungente, e é conhecido por sua capacidade de formar éteres silílicos estáveis ao reagir com álcoois. O cloreto de TBDMS é sensível à umidade e deve ser manuseado em condições anidras para evitar a hidrólise, que pode levar à formação de álcoois silílicos. É solúvel em solventes orgânicos como diclorometano e éter, mas é insolúvel em água. O composto é comumente usado na síntese de moléculas orgânicas complexas, particularmente no campo da química medicinal e na síntese de produtos naturais, devido à sua eficácia em proteger seletivamente grupos funcionais durante reações em múltiplas etapas. Precauções adequadas de segurança devem ser tomadas ao manusear o cloreto de TBDMS, pois pode ser irritante para a pele e o sistema respiratório.

Fórmula: C₆H₁₅ClSi

InChI: InChI=1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3

Chave InChI: InChIKey=BCNZYOJHNLTNEZ-UHFFFAOYSA-N

SMILES: C([Si](C)(C)Cl)(C)(C)C

Sinónimos:

• (1,1-Dimethylethyl)dimethylsilyl chloride
• 2-(Chlorodimethylsilyl)-2-methylpropane
• 2-[4-(TertButyldimethylsilanyloxy)phenyl] chloride
• Chloro(1,1-dimethylethyl)dimethylsilane
• Chloro-tert-butyldimethylsilane
• Chlorodimethyl-tert-butylsilane
• Dimethyl(1,1-dimethylethyl)chlorosilane
• Dimethyl-tert-butylchlorosilane
• Dimethyl-tert-butylsilyl chloride
• Ls 1190
• Silane, T-Butyl-Dimethylchloro-
• Silane, chloro-tert-butyldimethyl-
• T-Butyldimethylchlorosilane
• TBDMS chloride
• TBDMS-Cl
• TBSCl
• Terc-Butilclorodimetilsilano
• Tert-Butyldimethylchlorosilane
• tert-Butyl(dimethyl)silane chloride
• tert-Butylchlordimethylsilan
• tert-Butylchlorodimethylsilane
• tert-Butyldimethylsilyl chloride
• (1-chloro-2-methylpropan-2-yl)(dimethyl)silane
• Silane, chloro(1,1-dimethylethyl)dimethyl-
• Tert-Butyl Dimethyl Silyl Chloride
• TBDMSCL
• Tertiary butyldimethylchlorosilane
• Tert-butyl-dimethyl chlorosilance
• Tert-Butyl Dimethylchlorosilane

tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]

CAS: 18162-48-6

Fórmula: C₆H₁₅ClSi

Pureza: >98.0%(GC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 150.72

Ref: 3B-B0995

tert-Butyldimethylchlorosilane, 50% w/w in toluene

CAS: 18162-48-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₆H₁₅ClSi

Cor e Forma: Clear colorless, Liquid

Peso molecular: 150.72

Ref: 02-B21286

tert-Butyldimethylchlorosilane, 97%

CAS: 18162-48-6

tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines

Fórmula: C₆H₁₅ClSi

Pureza: 97%

Cor e Forma: Colorless to white, Crystals or powder or crystalline powder or lumps or fused solid

Peso molecular: 150.72

Ref: 02-A13064

tert-Butyldimethylchlorosilane

CAS: 18162-48-6

Fórmula: C₆H₁₅ClSi

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 150.7218

Ref: IN-DA0035NH

tert-Butyldimethylsilyl chloride

CAS: 18162-48-6

tert-Butyldimethylsilyl chloride

Fórmula: C₆H₁₅ClSi

Pureza: ≥95%

Cor e Forma: white crystals

Peso molecular: 150.72179g/mol

Ref: 54-OR019066

tert-Butyldimethylchlorosilane

CAS: 18162-48-6

Fórmula: C₆H₁₅ClSi

Pureza: ≥ 99.0%

Cor e Forma: White crystals

Peso molecular: 150.73

Ref: 7W-GK9215

tert-Butyldimethylchlorosilane

CAS: 18162-48-6

S03300 - tert-Butyldimethylchlorosilane

Fórmula: C₆H₁₅ClSi

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 150.72

Ref: 10-S03300

tert-Butyldimethylsilyl chloride, 50% solution in toluene

CAS: 18162-48-6

tert-Butyldimethylsilyl chloride, 50% solution in toluene

Pureza: ≥95%

Cor e Forma: Colourless Liquid

Peso molecular: 150.72g/mol

Ref: 54-OR40716

tert-Butyldimethylsilyl Chloride

CAS: 18162-48-6

Applications Used to protect alcohols during organic synthesis.
References Shen, H., et al.: J. Med. Chem., 53, 2666 (2010), Qiang, L., et al.: Bioorg. Med. Chem. Lett., 20, 836 (2010),

Fórmula: C₆H₁₅ClSi

Cor e Forma: White Solid

Peso molecular: 150.72

Ref: TR-B691080

tert-Butyldimethylsilyl chloride

CAS: 18162-48-6

Tert-butyldimethylsilyl chloride is a silicon-containing compound that is used to prepare the tert-butyl group, which is an important part of many organic compounds. Tert-butyldimethylsilyl chloride reacts with trifluoroacetic acid to form hydrogen bonds. It can also react with hydrochloric acid to form a tert-butyl chloride, which is soluble in water and hydrolyzes in human serum. Tert-butyldimethylsilyl chloride has been used for the synthesis of carbohydrates and fatty acids. It has been used as a sample preparation agent for gas chromatography mass spectrometry and high performance liquid chromatography. The reaction solution can be prepared by reacting tert-butyldimethylsilyl chloride with an alcohol or carboxylic acid in the presence of base at low temperature. Tert-butyldimethylsilyl chloride can be synthesized by reacting

Fórmula: C₆H₁₅ClSi

Pureza: Min. 95 Area-%

Cor e Forma: Colorless Powder

Peso molecular: 150.73 g/mol

Ref: 3D-FB07718

t-BUTYLDIMETHYLCHLOROSILANE

CAS: 18162-48-6

Trialkylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
tert-Butyldimethylchlorosilane; TBS-Cl; Chlorodimethyl-t-butylsilane; tert-Butylchlorodimethylsilane; Chloro(1,1-dimethylethyl)dimethylsilane
Excellent for 1° and 2° alcoholsSilylation catalyzed by imidazoleBlocking agent widely used in prostaglandin synthesisStable to many reagentsCan be selectively cleaved in presence of acetate, THP and benzyl ethers among othersUsed for the protection of alcohols, amines, thiols, lactams, and carboxylic acidsClean NMR characteristics of protecting groupSilylation reagent - derivatives resistant to Grignards, alkyl lithium compounds, etcFacile removal with flouride ion sourcesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Fórmula: C₆H₁₅ClSi

Pureza: 97%

Cor e Forma: Translucent Solid

Peso molecular: 150.72

Ref: 3H-SIB1935.0

t-Butyldimethylchlorosilane, min. 97%

CAS: 18162-48-6

t-Butyldimethylchlorosilane, min. 97%

Fórmula: (CH₃)₃CSi(CH₃)₂Cl

Pureza: min. 97%

Cor e Forma: white pwdr.

Peso molecular: 150.70

Ref: 08-14-1775

tert-Butyldimethylsilyl Chloride (TBDMS.Cl) extrapure, 98%

CAS: 18162-48-6

Fórmula: C₆H₁₅ClSi

Pureza: min. 98%

Cor e Forma: White, Hygroscopic compound, Clear, Colourless

Peso molecular: 150.73

Ref: SR-39227