CAS 187235-37-6

PA 824

Descrição:

PA-824, com o número CAS 187235-37-6, é um composto sintético estudado principalmente por seu potencial uso no tratamento da tuberculose, particularmente em cepas resistentes a medicamentos. Pertence à classe dos nitroimidazóis e exibe atividade bactericida contra Mycobacterium tuberculosis. PA-824 funciona através de um mecanismo de ação único, onde é ativado em condições anaeróbicas, levando à geração de espécies reativas de nitrogênio que interrompem os processos celulares bacterianos. Este composto é caracterizado por sua capacidade de penetrar efetivamente a parede celular micobacteriana, tornando-se um candidato promissor na terapia da tuberculose. Além disso, PA-824 mostrou propriedades farmacocinéticas favoráveis, incluindo biodisponibilidade oral e uma meia-vida prolongada, que apoiam seu potencial para esquemas de dosagem uma vez ao dia. A pesquisa continua a avaliar sua eficácia e segurança em ambientes clínicos, particularmente em terapias combinadas destinadas a melhorar os resultados do tratamento para pacientes com tuberculose multirresistente. No geral, PA-824 representa um avanço significativo na busca por agentes anti-tuberculose eficazes.

Fórmula: C₁₄H₁₂F₃N₃O₅

InChI: InChI=1/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

Chave InChI: InChIKey=ZLHZLMOSPGACSZ-NSHDSACASA-N

SMILES: N(=O)(=O)C1=CN2C(=N1)OC[C@@H](OCC3=CC=C(OC(F)(F)F)C=C3)C2

Sinónimos:

• (6S)-2-Nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-6-[[4-(Trifluoromethoxy)benzyl]oxy]-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-Pa 824
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (S)-
• Pa-824
• Pretomanid
• EOS-60675
• PA-824, >=98%
• PA-824;PA824;PA 824
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine PA-824
• 2-NITRO-6(S)-[4-(TRIFLUOROMETHOXY)BENZYLOXY]-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZINE
• CS-930
• (S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-PA 824 (Pretomanid)
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]metho
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 98+%
• PRETOMANID;(S)-PA 824
• (S)-6-(4-(trifluoromethoxy)benzyloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• xy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine
• PA-824(Pretomanid)

PA-824

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: >98.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 359.26

Ref: 3B-P2718

(6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]methoxy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 359.2574

Ref: IN-DA0074WJ

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 99%

Cor e Forma: pale yellow solid

Peso molecular: 359.26g/mol

Ref: 54-PC400580

Pretomanid

CAS: 187235-37-6

Pretomanid

Pureza: ≥98%

Peso molecular: 359.26g/mol

Ref: 54-BUP06246

Pretomanid (PA-824)

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 359.26

Ref: 4Z-P-138001

Pretomanid

CAS: 187235-37-6

Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 98.75% - 99.96%

Cor e Forma: Solid

Peso molecular: 359.26

Ref: TM-T6096

(S)-PA 824 (Pretomanid)

Produto Controlado

CAS: 187235-37-6

Applications A novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Fórmula: C₁₄H₁₂F₃N₃O₅

Cor e Forma: Neat

Peso molecular: 359.26

Ref: TR-P122500

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine ia slo known as PA-824. An anti-tuberculosis drug that affects both replicating and non-replicating Mycobacterium tuberculosis via cell wall inhibition and respiratory poisoning..

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: Min. 98 Area-%

Cor e Forma: Off-White Slightly Yellow Powder

Peso molecular: 359.26 g/mol

Ref: 3D-FP26721

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 98%

Cor e Forma: Liquid, No data available.

Peso molecular: 359.261

Ref: 10-F462409