CAS 191114-48-4

Telitromicina

Descrição:

Telitromicina é um antibiótico sintético pertencente à classe dos cetolídeos, usado principalmente para tratar infecções do trato respiratório causadas por várias bactérias. Apresenta um amplo espectro de atividade contra organismos Gram-positivos e alguns Gram-negativos, tornando-se eficaz contra patógenos como Streptococcus pneumoniae e Haemophilus influenzae. Telitromicina atua inibindo a síntese de proteínas bacterianas ao se ligar à subunidade ribossomal 50S, impedindo assim o crescimento e a reprodução das bactérias. Sua estrutura química apresenta um grupo cetona e uma espinha dorsal macrolídea, que contribuem para suas propriedades farmacológicas únicas. Telitromicina é administrado por via oral e é conhecido por sua meia-vida relativamente longa, permitindo uma dosagem uma vez ao dia. No entanto, está associado a potenciais efeitos colaterais, incluindo distúrbios gastrointestinais e, em casos raros, toxicidade hepática. Devido a preocupações sobre resistência e segurança, seu uso se tornou mais restrito nos últimos anos. No geral, Telitromicina representa uma opção importante no arsenal de antibióticos, particularmente para tratar infecções bacterianas específicas.

Fórmula: C₄₃H₆₅N₅O₁₀

InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

Chave InChI: InChIKey=LJVAJPDWBABPEJ-PNUFFHFMSA-N

SMILES: C[C@@]12[C@](N(CCCCN3C=C(N=C3)C=4C=CC=NC4)C(=O)O1)([C@@H](C)C(=O)[C@H](C)C[C@](OC)(C)[C@H](O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC)[H]

Sinónimos:

• (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• (3aS,4S,7R,9R,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside - 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione (1:1)
• (3aS,4S,7R,9R,10R,11S,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-
• Hmr 3647
• Ketek
• Levviax
• Ru 66647
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

CAS: 191114-48-4

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 812.0037

Ref: IN-DA002F1S

Telithromycin

CAS: 191114-48-4

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 812.00

Ref: 7W-GA2425

Telithromycin

CAS: 191114-48-4

Telithromycin is a macrolide antibiotic and erythromycin derivative,70S bacterial ribosome, antimicrobial, respiratory infections,inhibits protein synthesis.

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 812

Ref: TM-T4543

Telithromycin

CAS: 191114-48-4

Fórmula: C₄₃H₆₅N₅O₁₀

Peso molecular: 812.02

Ref: 4Z-T-443001

Telithromycin 90%

Produto Controlado

CAS: 191114-48-4

Applications Telithromycin is a ketolide antibiotic, used to treat respiratory infections
References Lee, J., et al.: Pulmonary Pharmacology & Therapeutics, 21, 860 (2008), Wajima, T., et al.: J. Med. Microbiol., 57, 1383 (2008), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009),

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 90%

Cor e Forma: Light Orange Colour

Peso molecular: 812.00

Ref: TR-T016500

Telithromycin - 95%

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 812 g/mol

Ref: 3D-AT164862

Telithromycin

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 812 g/mol

Ref: 3D-AT28021

Telithromycin, 95%

CAS: 191114-48-4

Telithromycin is used to treat respiratory infections. Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 95%

Cor e Forma: Crystalline solid

Peso molecular: 812.02

Ref: 02-J66820