CAS 19171-19-8

Pomalidomida

Descrição:

Pomalidomida é um fármaco imunomodulador usado principalmente no tratamento do mieloma múltiplo e certas outras malignidades hematológicas. Pertence a uma classe de compostos conhecidos como análogos da talidomida, que exercem seus efeitos através de vários mecanismos, incluindo a modulação do sistema imunológico e a inibição do crescimento tumoral. A fórmula química de Pomalidomida é C13H11N3O4S, e apresenta uma estrutura única que inclui um anel de ftalimida, um grupo sulfonamida e uma cadeia lateral aromática. Pomalidomida é conhecido por sua capacidade de aumentar a atividade de células T e células assassinas naturais, bem como por suas propriedades antiangiogênicas, que ajudam a inibir a formação de novos vasos sanguíneos que os tumores precisam para crescer. O fármaco é tipicamente administrado por via oral e tem uma meia-vida relativamente longa, permitindo horários de dosagem convenientes. No entanto, está associado a potenciais efeitos colaterais, incluindo toxicidades hematológicas, e requer monitoramento cuidadoso durante o tratamento. No geral, Pomalidomida representa um avanço significativo nas terapias direcionadas ao câncer.

Fórmula: C₁₃H₁₁N₃O₄

InChI: InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

Chave InChI: InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N

SMILES: O=C1N(C(=O)C=2C1=CC=CC2N)C3C(=O)NC(=O)CC3

Sinónimos:

• 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
• 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
• 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
• 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
• 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
• 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
• 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
• Actimid
• Cc 4047
• Imnovid
• Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-

Pomalidomide

CAS: 19171-19-8

Fórmula: C₁₃H₁₁N₃O₄

Pureza: >98.0%(HPLC)

Cor e Forma: White to Yellow to Green powder to crystaline

Peso molecular: 273.25

Ref: 3B-P2074

4-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CAS: 19171-19-8

Fórmula: C₁₃H₁₁N₃O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 273.2441

Ref: IN-DA002FFT

Pomalidomide

CAS: 19171-19-8

Pomalidomide

Pureza: 98%

Peso molecular: 273.24g/mol

Ref: 54-BIPC1018

Pomalidomide

CAS: 19171-19-8

Fórmula: C₁₃H₁₁N₃O₄

Cor e Forma: Yellow Solid

Peso molecular: 273.25

Ref: 4Z-P-178001

Pomalidomide

CAS: 19171-19-8

Pomalidomide

Pureza: ≥98%

Peso molecular: 273.24g/mol

Ref: 54-BUP17160

Pomalidomide

CAS: 19171-19-8

Cor e Forma: Neat

Ref: 86-MM3919.00

Pomalidomide

CAS: 19171-19-8

Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for CRBN. Cost-effective and quality-assured.

Fórmula: C₁₃H₁₁N₃O₄

Pureza: 98.8% - >99.99%

Cor e Forma: Solid

Peso molecular: 273.24

Ref: TM-T2384

Pomalidomide-d4

CAS: 19171-19-8

Fórmula: C₁₃H₇N₃O₄D₄

Cor e Forma: White To Off-White Solid

Peso molecular: 277.27

Ref: 4Z-P-178012

Pomalidomide

CAS: 19171-19-8

Fórmula: C₁₃H₁₁N₃O₄

Pureza: ≥ 98.5%

Cor e Forma: Yellow to green powder

Peso molecular: 273.24

Ref: 7W-GP0062

Pomalidomide

CAS: 19171-19-8

Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

Fórmula: C₁₃H₁₁N₃O₄

Cor e Forma: Yellow

Peso molecular: 273.24

Ref: TR-P688200

Pomalidomide-d5

Produto Controlado

CAS: 19171-19-8

Applications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

Fórmula: C₁₃D₅H₆N₃O₄

Cor e Forma: Neat

Peso molecular: 278.27

Ref: TR-P688203

Pomalidomide - Bio-X ™

Produto Controlado

CAS: 19171-19-8

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.
Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₃H₁₁N₃O₄

Pureza: Min. 99 Area-%

Cor e Forma: Powder

Peso molecular: 273.24 g/mol

Ref: 3D-BP164278

Pomalidomide

Produto Controlado

CAS: 19171-19-8

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.

Fórmula: C₁₃H₁₁N₃O₄

Pureza: Min. 98 Area-%

Cor e Forma: Yellow Powder

Peso molecular: 273.24 g/mol

Ref: 3D-FA30210

4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CAS: 19171-19-8

Fórmula: C₁₃H₁₁N₃O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 273.248

Ref: 10-F230365

Pomalidomide-d2 (Major)

Produto Controlado

CAS: 19171-19-8

Fórmula: C₁₃D₂H₉N₃O₄

Cor e Forma: Neat

Peso molecular: 275.26

Ref: TR-P688207