CAS 19186-35-7

(5R,5aR,8aR)-5-(3,4,5-trimetoxifenil)-5,8,8a,9-tetraidrofurano[3',4':6,7]nafto[2,3-d][1,3]dioxol-6(5aH)-ona

Descrição:

A substância química com o nome "(5R,5aR,8aR)-5-(3,4,5-trimetoxifenil)-5,8,8a,9-tetraidrofurano[3',4':6,7]nafto[2,3-d][1,3]dioxol-6(5aH)-ona" e número CAS "19186-35-7" é um composto orgânico complexo caracterizado por sua intrincada estrutura policíclica, que inclui um núcleo de naftaleno fundido com um dioxolano e um moiety de tetrahidrofurano. Este composto apresenta múltiplos grupos metóxi, que são conhecidos por melhorar a solubilidade e influenciar a atividade biológica. A estereoquímica indicada pelas configurações R sugere arranjos espaciais específicos que podem afetar significativamente a reatividade do composto e suas interações com alvos biológicos. Compostos desse tipo costumam exibir propriedades farmacológicas interessantes, tornando-os objetos de interesse na química medicinal. Além disso, a presença de múltiplos grupos funcionais pode levar a uma reatividade química diversificada, permitindo modificações potenciais que poderiam aumentar a eficácia terapêutica ou reduzir a toxicidade. No geral, este composto exemplifica a complexidade e diversidade encontradas na química orgânica, particularmente no âmbito da síntese de produtos naturais e desenvolvimento de medicamentos.

Fórmula: C₂₂H₂₂O₇

InChI: InChI=1/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1

Chave InChI: InChIKey=ZGLXUQQMLLIKAN-SVIJTADQSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C(C[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]

Sinónimos:

• (-)-Anthricin
• (5R,5aR,8aR)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4-Deoxypodophyllotoxin
• As 2-3
• Deoxypodophyllotoxin
• Desoxypodophyllotoxin
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα)]-
• Podophyllotoxin, deoxy-
• Silicicolin
• Anthricin/Deoxypodophyllotoxin
• anthric
• Podophyllotoxin 9-Desoxy Impurity
• Deoxypodophyllotoxin, deoxypodophyllotoxin

(-)-Deoxypodophyllotoxin

CAS: 19186-35-7

Fórmula: C₂₂H₂₂O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 398.4059

Ref: IN-DA002FHT

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin

Pureza: ≥98%

Peso molecular: 398.41g/mol

Ref: 54-BUP16322

Deoxypodophyllotoxin

CAS: 19186-35-7

Fórmula: C₂₂H₂₂O₇

Peso molecular: 398.41

Ref: 7W-GY9442

Podophyllotoxin Impurity 5

CAS: 19186-35-7

Fórmula: C₂₂H₂₂O₇

Cor e Forma: White To Off-White Solid

Peso molecular: 398.41

Ref: 4Z-P-122005

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.

Fórmula: C₂₂H₂₂O₇

Pureza: 95%~99%

Peso molecular: 398.41

Ref: BP-SBP02032

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.

Fórmula: C₂₂H₂₂O₇

Pureza: 99.65% - 99.84%

Cor e Forma: Solid

Peso molecular: 398.41

Ref: TM-TN1087

4-Deoxypodophyllotoxin

CAS: 19186-35-7

4-Deoxypodophyllotoxin is a natural lignan, which is a type of secondary metabolite. It is primarily sourced from the roots and rhizomes of several plants belonging to the Podophyllum species, such as Podophyllum hexandrum. This compound exhibits its mode of action by interfering with microtubule assembly, thus disrupting cell division and leading to apoptotic cell death. Its effectiveness at halting mitosis makes it a subject of interest in cancer research.

Fórmula: C₂₂H₂₂O₇

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 398.41 g/mol

Ref: 3D-FD157413

4-Deoxypodophyllotoxin

Produto Controlado

CAS: 19186-35-7

Applications 4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin was also shown to inhibit the passive cutaneous anaphylaxis reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, C.X., et al.: Planta. Med., 70, 474 (2004); Peng, Xu., et al.: Neurotoxicol., 31, 680 (2010); Kim, Y., et al.: Planta, Med., 68, 271 (2002);

Fórmula: C₂₂H₂₂O₇

Cor e Forma: Off-White

Peso molecular: 398.41

Ref: TR-D249500