CAS 192725-17-0: Lopinavir

Descrição: Lopinavir é um medicamento antirretroviral utilizado principalmente no tratamento do HIV/AIDS. Pertence à classe dos inibidores da protease e é frequentemente combinado com ritonavir para aumentar sua eficácia e biodisponibilidade. A fórmula química de Lopinavir é C37H48N4O5, e seu peso molecular é de aproximadamente 628,88 g/mol. Lopinavir é caracterizado por sua estrutura complexa, que inclui múltiplos anéis e grupos funcionais que contribuem para sua atividade farmacológica. Geralmente é administrado por via oral na forma de comprimidos ou solução líquida. A substância é conhecida por sua capacidade de inibir a enzima protease do HIV, impedindo assim a replicação viral. Lopinavir é geralmente bem tolerado, mas pode ter efeitos colaterais, incluindo distúrbios gastrointestinais e potenciais impactos no metabolismo lipídico. Devido ao seu papel no tratamento do HIV, Lopinavir é frequentemente parte de regimes de terapia combinada, que podem incluir outros agentes antirretrovirais para melhorar os resultados do tratamento e reduzir o risco de resistência.

Fórmula: C₃₇H₄₈N₄O₅

InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

Chave InChI: InChIKey=KJHKTHWMRKYKJE-SUGCFTRWSA-N

SMILES: O=C1NCCCN1C(C(=O)NC(CC=2C=CC=CC2)CC(O)C(NC(=O)COC=3C(=CC=CC3C)C)CC=4C=CC=CC4)C(C)C

Sinónimos:

• A 157378.0
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• 1(2H)-Pyrimidineacetamide, N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, [1S-[1R*(R*),3R*,4R*]]-
• ABT 378
• ABT-378
• UNII-2494G1JF75
• Kaletra
• (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• 1(2H)-Pyrimidineacetamide, N-((1S,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahyrdo-alpha-1-methylethyl)-2-oxo-, (alphaS)-
• (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: >98.0%(HPLC)
• Cor e Forma: White to Light yellow powder to crystal
• Peso molecular: 628.81

Lopinavir for peak identification CRS

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Peso molecular: 628.8008

Lopinavir for system suitability CRS

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Peso molecular: 628.8008

Lopinavir RS

CAS: 192725-17-0

Lopinavir CRS

CAS: 192725-17-0

Lopinavir

CAS: 192725-17-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Fórmula: C₃₇H₄₈N₄O₅
• Cor e Forma: White Off-White Powder
• Peso molecular: 628.36247

(αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: %
• Cor e Forma: Solid
• Peso molecular: 628.8008

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Cor e Forma: Off-White Solid
• Peso molecular: 628.81

Lopinavir EP Impurity H

CAS: 192725-17-0

• Fórmula: C₂₉H₃₂N₂O₄
• Cor e Forma: White To Off-White Solid
• Peso molecular: 472.59

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: ≥ 98.0% (anhydrous basis)
• Cor e Forma: White crystalline powder
• Peso molecular: 628.80

Lopinavir, 98%

CAS: 192725-17-0

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: 98%
• Cor e Forma: White to beige, Powder
• Peso molecular: 628.81

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Cor e Forma: Neat
• Peso molecular: 628.80

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Cor e Forma: Neat
• Peso molecular: 628.80

Lopinavir

CAS: 192725-17-0

Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with …

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: 98% - 99.14%
• Cor e Forma: White Crystalline Solid
• Peso molecular: 628.8

Lopinavir

CAS: 192725-17-0

• Pureza: 95.0%
• Cor e Forma: Liquid
• Peso molecular: 628.8140258789062

Lopinavir

CAS: 192725-17-0

Stability Hygroscopic Applications A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is …

• Fórmula: C₃₇H₄₈N₄O₅
• Cor e Forma: White Solid
• Peso molecular: 628.80

Lopinavir - Bio-X ™

CAS: 192725-17-0

Chemically derived from ritonavir, Lopinavir belongs to the amphetamines. Lopinavir is clinically used in the …

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: Min. 98 Area-%
• Cor e Forma: Powder
• Peso molecular: 628.8 g/mol

Lopinavir

CAS: 192725-17-0

Anti-viral; HIV protease inhibitor

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: Min. 97.5 Area-%
• Cor e Forma: White Off-White Powder
• Peso molecular: 628.8 g/mol

N5-Des[(2,6-dimethylphenoxy)acetyl] N5-Formal Lopinavir

CAS: 192725-17-0

• Fórmula: C₂₈H₃₈N₄O₄
• Cor e Forma: Neat
• Peso molecular: 494.63