CAS 192725-17-0
:Lopinavir
Descrição:
Lopinavir é um medicamento antirretroviral utilizado principalmente no tratamento do HIV/AIDS. Pertence à classe dos inibidores da protease e é frequentemente combinado com ritonavir para aumentar sua eficácia e biodisponibilidade. A fórmula química de Lopinavir é C37H48N4O5, e seu peso molecular é de aproximadamente 628,88 g/mol. Lopinavir é caracterizado por sua estrutura complexa, que inclui múltiplos anéis e grupos funcionais que contribuem para sua atividade farmacológica. Geralmente é administrado por via oral na forma de comprimidos ou solução líquida. A substância é conhecida por sua capacidade de inibir a enzima protease do HIV, impedindo assim a replicação viral. Lopinavir é geralmente bem tolerado, mas pode ter efeitos colaterais, incluindo distúrbios gastrointestinais e potenciais impactos no metabolismo lipídico. Devido ao seu papel no tratamento do HIV, Lopinavir é frequentemente parte de regimes de terapia combinada, que podem incluir outros agentes antirretrovirais para melhorar os resultados do tratamento e reduzir o risco de resistência.
Fórmula:C37H48N4O5
InChI:InChI=1/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
Chave InChI:InChIKey=KJHKTHWMRKYKJE-SUGCFTRWSA-N
SMILES:[C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@H](CC2=CC=CC=C2)NC(COC3=C(C)C=CC=C3C)=O)O)=O)([C@@H](C)C)N4C(=O)NCCC4
Sinónimos:- A 157378.0
- 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
- 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
- (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
- 1(2H)-Pyrimidineacetamide, N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, [1S-[1R*(R*),3R*,4R*]]-
- ABT 378
- ABT-378
- UNII-2494G1JF75
- Kaletra
- (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
- (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
- (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
- 1(2H)-Pyrimidineacetamide, N-((1S,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahyrdo-alpha-1-methylethyl)-2-oxo-, (alphaS)-
- (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide
- LOPINAVIR
- Aluviran
- Koletra
- (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
- (2s)-n-[(2r,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
- (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
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20 produtos.
Lopinavir
CAS:Fórmula:C37H48N4O5Pureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:628.81LOPINAVIR FOR SYSTEM SUITABILITY CRS
CAS:LOPINAVIR FOR SYSTEM SUITABILITY CRSFórmula:C37H48N4O5Peso molecular:628.8008LOPINAVIR FOR PEAK IDENTIFICATION CRS
CAS:LOPINAVIR FOR PEAK IDENTIFICATION CRSFórmula:C37H48N4O5Peso molecular:628.8008Lopinavir
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFórmula:C37H48N4O5Cor e Forma:White Off-White PowderPeso molecular:628.36247(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
CAS:Fórmula:C37H48N4O5Pureza:%Cor e Forma:SolidPeso molecular:628.8008Ref: IN-DA003RD4
1g158,00€5gA consultar100gA consultar10mg30,00€25mg50,00€50mg50,00€100mg65,00€250mg99,00€Lopinavir EP Impurity H
CAS:Fórmula:C29H32N2O4Cor e Forma:White To Off-White SolidPeso molecular:472.58Lopinavir
CAS:Fórmula:C37H48N4O5Pureza:≥ 98.0% (anhydrous basis)Cor e Forma:White crystalline powderPeso molecular:628.80Lopinavir
CAS:<p>Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation.</p>Fórmula:C37H48N4O5Pureza:98% - 99.62%Cor e Forma:White Crystalline SolidPeso molecular:628.8Lopinavir
CAS:<p>Stability Hygroscopic<br>Applications A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is a COVID19-related research product.<br>References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)<br></p>Fórmula:C37H48N4O5Cor e Forma:White SolidPeso molecular:628.80Lopinavir
CAS:<p>Anti-viral; HIV protease inhibitor</p>Fórmula:C37H48N4O5Pureza:Min. 97.5 Area-%Cor e Forma:White Off-White PowderPeso molecular:628.8 g/molLopinavir - Bio-X ™
CAS:<p>Chemically derived from ritonavir, Lopinavir belongs to the amphetamines. Lopinavir is clinically used in the prevention and treatment of HIV infections as it acts as HIV-1 protease inhibitor. In 2020, lopinavir was tested to treat COVID-19 patients and although it led to a higher rate of gastrointestinal side effects, the Lopinavir-treated group had a lower incidence of severe complications. Overall it was deemed not to work as a treatment.</p>Fórmula:C37H48N4O5Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:628.8 g/molN5-Des[(2,6-dimethylphenoxy)acetyl] N5-Formal Lopinavir
CAS:Produto ControladoFórmula:C28H38N4O4Cor e Forma:NeatPeso molecular:494.63Ref: 10-F079428
Produto descontinuado
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