CAS 19396-06-6

Polioxina B

Descrição:

Polioxina B é um composto antifúngico natural produzido pela fermentação de certas espécies de Streptomyces, particularmente Streptomyces griseus. É classificado como um antibiótico nucleosídeo e é conhecido principalmente por sua capacidade de inibir a síntese de quitina, um componente crítico das paredes celulares dos fungos. Este mecanismo de ação torna Polioxina B eficaz contra uma variedade de patógenos fúngicos, particularmente em ambientes agrícolas onde é utilizado como biopesticida. O composto exibe um amplo espectro de atividade antifúngica, direcionando-se a fungos como as espécies de Fusarium e Rhizoctonia. Polioxina B é caracterizado por sua toxicidade relativamente baixa para mamíferos, o que o torna uma alternativa mais segura aos fungicidas sintéticos. Além disso, é solúvel em água, permitindo fácil aplicação em várias formulações. Seu uso é particularmente valorizado na agricultura orgânica devido à sua origem natural e impacto ambiental mínimo. No geral, Polioxina B representa uma ferramenta importante no manejo de doenças fúngicas em culturas, promovendo práticas agrícolas sustentáveis.

Fórmula: C₁₇H₂₅N₅O₁₃

InChI: InChI=1S/C17H25N5O13/c18-6(8(25)5(24)3-34-16(19)32)13(29)20-7(15(30)31)11-9(26)10(27)14(35-11)22-1-4(2-23)12(28)21-17(22)33/h1,5-11,14,23-27H,2-3,18H2,(H2,19,32)(H,20,29)(H,30,31)(H,21,28,33)/t5-,6-,7-,8+,9-,10+,11+,14+/m0/s1

Chave InChI: InChIKey=YFZNSPMAOIVQRP-YVKGXWRCSA-N

SMILES: O[C@H]1[C@@H](O[C@]([C@H](NC([C@H]([C@@H]([C@H](COC(N)=O)O)O)N)=O)C(O)=O)([C@H]1O)[H])N2C=C(CO)C(=O)NC2=O

Sinónimos:

• (2S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}ethanoic acid (non-preferred name)
• (2S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{(2R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}ethanoic acid (non-preferred name)
• 5-(2-Amino-5-O-carbamoyl-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-beta-D-allofuranuronic acid
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-<span class="text-smallcaps">L</smallcap>-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-<smallcap>D</span>-allofuranuronic acid
• Allofuranuronic acid, 5-(2-amino-2-deoxy-<span class="text-smallcaps">L</smallcap>-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-, monocarbamate (ester), β-<smallcap>D</span>-
• Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-, monocarbamate (ester), beta-D-
• Duoyangqing
• Milpan
• Polar
• Polar (antibiotic)
• Polyoxin AL
• Polyoxin B
• Polyoxin B 34% Tk
• {[2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}acetic acid (non-preferred name)
• β-<span class="text-smallcaps">D</smallcap>-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-<smallcap>L</span>-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
• Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-, monocarbamate (ester), β-D-
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-D-allofuranuronic acid
• β-D-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
• 5-(2-amino-5-o-carbamoyl-2-deoxy-l-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1-(2h)-pyrimidinyl)-beta-d-allofuranuronicacid
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid
• 5-[[2-amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronicacid
• ro-5-(hydroxymethyl)-2,4-dioxo-1(2h)-pyrimidinyl)-,monocarbamate(ester),bet
• polyoxin AL(JMAF)
• polyoxinal
• 5-[(2-Amino-5-O-carbamoyl-2-deoxy-L-xylonoyl)amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid
• 5-[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylos-1-ylamino]-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
• 5-[[2-amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronic acid
• allofuranuronicacid,5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihyd
• 5-{[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl] amino}-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimnidinyl]-β-D-allofur-a-nuronic acid
• POLYXIN

b-D-Allofuranuronic acid,5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-

CAS: 19396-06-6

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: 70%

Cor e Forma: Solid

Peso molecular: 507.4061

Ref: IN-DA00I31H

Polyoxin b

CAS: 19396-06-6

Polyoxin b

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: ≥95%

Cor e Forma: solid

Peso molecular: 507.41g/mol

Ref: 54-OR927861

Polyoxin B

CAS: 19396-06-6

Polyoxin B

Pureza: ≥70%

Peso molecular: 507.41g/mol

Ref: 54-BUP03267

Polyoxin B

CAS: 19396-06-6

Fórmula: C₁₇H₂₅N₅O₁₃

Peso molecular: 507.41

Ref: 4Z-P-288002

Polyoxin B

CAS: 19396-06-6

Polyoxin B is an antifungal peptidyl nucleoside antibiotic that inhibits fungal cell wall biosynthesis.

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: 79.94%

Cor e Forma: Solid

Peso molecular: 507.41

Ref: TM-T28436

Polyoxin B

CAS: 19396-06-6

Polyoxin B is a natural product that is produced by the fungus Polyporus umbellatus. It is a synthetase inhibitor that specifically inhibits the enzyme malic acid synthetase in bacteria and fungi. Polyoxin B has been shown to have antifungal activity in vitro and to inhibit the growth of Cryptococcus neoformans, which may be due to its ability to inhibit terminal residues, such as acetate extract, bacterial strain, and synthase enzyme.

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: Min. 70%

Cor e Forma: Yellow Powder

Peso molecular: 507.41 g/mol

Ref: 3D-NP140526