CAS 19553-76-5

disialogangliósido G(D1B) do cérebro bovino

Descrição:

O disialogangliosídeo G (D1B) é um glicoesfingolípido complexo encontrado predominantemente no cérebro bovino, caracterizado por sua estrutura única que inclui dois resíduos de ácido siálico. Este gangliosídeo desempenha um papel crucial no reconhecimento célula-célula, sinalização e estabilidade da membrana dentro do sistema nervoso. Sua estrutura consiste em uma espinha dorsal de ceramida ligada a uma cadeia de carboidratos, que inclui os moieties de ácido siálico que contribuem para sua carga negativa e influenciam suas interações com outras biomoléculas. O D1B está envolvido em vários processos biológicos, incluindo desenvolvimento neuronal e plasticidade sináptica, e tem sido estudado por suas potenciais implicações em doenças neurodegenerativas. A presença de disialogangliosídeos como o D1B é significativa no contexto da função e patologia cerebral, pois estão implicados na modulação da atividade dos receptores e na proteção dos neurônios contra o estresse oxidativo. No geral, o D1B exemplifica o papel intrincado dos gangliosídeos na neurobiologia e seu potencial como alvos terapêuticos em distúrbios neurológicos.

Fórmula: C₈₄H₁₄₈N₄O₄₀

InChI: InChI=1/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

Sinónimos:

• (2R,4S,5R,6R)-2-[(2R,3S,4S,5R,6S)-5-[(2R,3S,4S,5S,6S)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-2-hydroxy-1-[(octadecanoylamino)methyl]heptadec-3-enoxy]tetrahydropyran-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxy-5-amino-6-[3-[(2R,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)tetrahydropyran-2-yl]oxy-1,2-dihydroxy-propyl]-4-hydroxy-tetrahydropyran-2-carboxylic acid
• G_D1b
• GD1b ganglioside
• Ganglioside C₁
• Ganglioside G₂
• Ganglioside G₂ (hexasaccharide)
• Ganglioside G_D1b
• Ganglioside G_III
• Ganglioside GD1b, Disialo, Diammonium Salt, Bovine Brain
• Ganglioside C1
• Ganglioside G2 (hexasaccharide)
• Ganglioside G2
• Ganglioside GIII
• Ganglioside GD1b
• GAL-BETA1,3GALNAC-BETA1,4(NEU5AC-ALPHA2,8)(NEU5AC-ALPHA2,3)GAL-BETA1,1' CERAMIDE
• II3(NEU5NAC)2GGOSE4 CERAMIDE
• Neu5Aca2,8Neu5Aca2,3(Galb1,3GalNAcb1,4)Galb1,4Glc Ceramide Synonym:GD1b
• Ganglioside GD1b (sodium salt)
• GANGLIOSIDE GD1B DISODIUM SALT
• Gd1b
• GANGLIOSIDE GD1B, DISIALO, HUMAN
• Ganglioside gd1B polysaccharide
• Aids-002546
• Neu5Acα2, 8Neu5Acα2, 3(Galβ1, 3GalNAcβ1, 4)Galβ1, 4Glc Ceramide
• GANGLIOSIDEGD1BDISODIUMSALT,BOVINEBRAIN
• DISIALOGANGLIOSIDE GD1B 2NA
• GAL-BETA1,3GALNAC-BETA1,4(NEU5AC-ALPHA2,8)(NEU5AC-ALPHA2,3)GAL-BETA1-4GLC-BETA1,1' CERAMIDE, HUMAN
• DISIALOGANGLIOSIDE GD1B (NH4+ SALT)
• Ganglioside GD1b Mixture (sodium salt)
• disialoganglioside G(D1B) from bovine brain
• GD1b-Ganglioside sodium
• DISIALOGANGLIOSIDE-GD1B
• GD1B 2NA
• Aids002546
• beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer
• II3(NEU5AC)2GGOSE4 CERAMIDE, 2NH4, BOVINE
• GANGLIOSIDE GD1B, DISIALO, HUMAN BRAIN
• GALBETA1,3GALNACBETA1,4(NEU5ACALPHA2,8)(NEU5ACALPHA2,3)GALBETA1-4GLCBETA1,1' CERAMIDE
• GD1B (NH4+ SALT)
• MONOSIALOGANGLIOSIDE GD1B DISODIUM SALT
• GANGLIOSIDE GD1B, DISIALO, DIAMMONIUM SALT, BOVINE
• GD1b ganglioside disodium salt (bovine brain)
• II3(NEUAC)2-GGOSE4CER
• II3(NEU5NAC)2GGOSE4 CERAMIDE, HUMAN
• ganglioside gd1b, disialo
• DISIALOGANGLIOSIDE GD1B, HUMAN

Ganglioside GD1b Mixture (sodium salt)

CAS: 19553-76-5

GD1b: acidic glycosphingolipid with two sialic acids linked to galactose, in plasma membranes, modulates cell signaling, increasing brain levels with age.

Fórmula: C₈₄H₁₄₆N₄O₃₉₂Na

Cor e Forma: Solid

Peso molecular: 1882.1

Ref: TM-T36861

Disialoganglioside GD1b (NH4-salt)

CAS: 19553-76-5

Fórmula: Unspecified

Pureza: >98%

Cor e Forma: Solid

Ref: 48-56-1104

GD1b-Ganglioside

CAS: 19553-76-5

Fórmula: C₈₄H₁₄₆N₄O₃₉·2Na

Pureza: ≥ 98.0%

Cor e Forma: White to yellow powder

Peso molecular: 1836.1 . 46.0

Ref: 7W-GC0141

GD1b-ganglioside sodium

CAS: 19553-76-5

GD1b (shown as sodium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with it’s two sialic acids linked α2,3/α2,8 to the inner galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD1b acts as a receptor for BK virus as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012).

Pureza: Min. 95%

Cor e Forma: Powder

Ref: 3D-OG03920

GD1b-Ganglioside ammonium

CAS: 19553-76-5

GD1b ganglioside (shown as ammonium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with its two sialic acids linked α2,3/α2,8 to the inner galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD1b ganglioside acts as a receptor for BK virus, as well as for heat-labile LTII-a toxin, produced by enteropathogenic E. coli. GD1b ganglioside also interacts with tetanus neurotoxin (TeNT) and is crucial for its entry into cells (Kolter, 2012). The functional significance of ammonia in the brain is not yet fully understood: see (Modi 1994).

Pureza: Min. 95%

Ref: 3D-OG175968

Ganglioside GD1b Disodium Salt (Bovine Brain)

CAS: 19553-76-5

Fórmula: C₅₀H₈₁N₂O₂₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1094.1771

Ref: IN-DA00AOEN